Gene · 9739
SETD1A: SET domain containing 1A, histone lysine methyltransferase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SETD1A: SET domain containing 1A, histone lysine methyltransferase. Genes, record 9739. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9739
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O15047 | Histone-lysine N-methyltransferase SETD1A | 1,707 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents14
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 63292 | O15047 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2085 | O15047 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1648 | O15047 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1648 | O15047 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2085 | O15047 | Espacenet |
| EP 4493206 A2 | 2025-01-22 | 25 | O15047 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 78339 | O15047 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 181310 | O15047 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 10148 | O15047 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 243727 | O15047 | Espacenet |
1 to 10 of 14
See all 14 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,845
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SETD1A papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 18 | 2025 |
| R35CA197569 | Mutations of Chromatin and its Modifying Machineries in Malignancies | 17 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 10 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| ZIADK075003 | Enhancer regulation by H3K4 methyltransferase KMT2D/MLL4 and associated factors | 9 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 7 | 2025 |
| ZIAAI000712 | Transcriptional control of herpes simplex virus lytic infection and latency-reactivation cycles | 7 | 2025 |
| R01CA200709 | Facilitated recruitment of MYC to chromatin by interaction with WDR5 | 6 | 2025 |
| ZIADK075017 | Epigenomic regulation of adipogenesis and obesity-associated adipose expansion | 6 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 5 | 2025 |
1 to 10 of 1,845Source NIH's project files
See all 1,845 nih grantsPapers2,264
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Analysis of Rare Coding Variation Identifies New Genetic Contributors to Schizophrenia. | bioRxiv | 2026 | 42818077 | PubTator, text mining | PubMed |
| Crosstalk between NUAK1 and the SETD1A complex regulates glycolysis and gluconeogenesis upon glucose deprivation. | J Biol Chem | 2026 | 42778105 | PubTator, text mining | PubMed |
| Reliability of Specific High-Intensity Interval Exercise Protocol for Judo Athletes. | Int J Sports Physiol Perform | 2026 | 42772724 | PubTator, text mining | PubMed |
| Reorientation of the SUMOylation landscape and altered L3mbtl2-mediated transcriptional activity in cancer-associated muscle contractile dysfunction. | Cell Death Discov | 2026 | 42717202 | PubTator, text mining | PubMed |
| Early-Onset Epilepsy with Developmental Delay - A Novel C.1640A>C Mutation in the SETD1A Gene with Sensorineural Hearing Loss. | Neurol India | 2026 | 42700128 | PubTator, text mining | PubMed |
| Effects of resistance training sets on cognition and brain-derived neurotrophic factor in cognitively impaired individuals: a quasi-experimental study. | J Gerontol A Biol Sci Med Sci | 2026 | 42678372 | PubTator, text mining | PubMed |
| Variable Expressiveness of a Novel Pathogenic SETD1A Missense Variant Linked to FLOS Domain Haploinsufficiency in a Mexican Pedigree. | Diseases | 2026 | 42645097 | PubTator, text mining | PubMed |
| Tracing the origins of de novo coronary collateral formation in cardiac repair. | Science | 2026 | 42623479 | PubTator, text mining | PubMed |
| Retraction Note: Histone methyltransferase SETD1A interacts with notch and promotes notch transactivation to augment ovarian cancer development. | BMC Cancer | 2026 | 42601603 | PubTator, text mining | PubMed |
| The Bcl11-Cxxc1 axis regulates stage-specific chromatin accessibility during lymphocyte development. | Genes Dev | 2026 | 42547288 | PubTator, text mining | PubMed |
1 to 10 of 2,264
See all 2,264 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9739
GET https://conductscience.org/api/genes/v1/9739/patents