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Gene · 9739

SETD1A: SET domain containing 1A, histone lysine methyltransferase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SETD1A: SET domain containing 1A, histone lysine methyltransferase. Genes, record 9739. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9739

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Gene

Symbol
SETD1A
HGNC
Name
SET domain containing 1A, histone lysine methyltransferase
HGNC
NCBI Gene ID
9739
NCBI Gene
HGNC ID
HGNC:29010
HGNC
Ensembl
ENSG00000099381
NCBI Gene
Aliases
EPEDD, EPEO2, KIAA0339, KMT2F, NEDSID, SET1A, Set1, Set1A
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O15047Histone-lysine N-methyltransferase SETD1A1,7074Ensembl, GeneID, HGNC

Source UniProt

Patents14

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463292O15047Espacenet
EP 4650780 A22025-11-192085O15047Espacenet
EP 4641201 A22025-10-291648O15047Espacenet
JP 2025517969 A2025-06-121648O15047Espacenet
JP 2025517970 A2025-06-122085O15047Espacenet
EP 4493206 A22025-01-2225O15047Espacenet
US 11446398 B22022-09-2078339O15047Espacenet
JP 2022524081 A2022-04-27181310O15047Espacenet
US 11078247 B22021-08-0310148O15047Espacenet
JP 2019054813 A2019-04-11243727O15047Espacenet

1 to 10 of 14

See all 14 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,845

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSETD1A papersNewest fiscal year
P30CA008748Cancer Center Support Grant182025
R35CA197569Mutations of Chromatin and its Modifying Machineries in Malignancies172025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center102025
P30CA016672Cancer Center Support Grant92025
ZIADK075003Enhancer regulation by H3K4 methyltransferase KMT2D/MLL4 and associated factors92025
P30CA046934University of Colorado Cancer Center Support Grant72025
ZIAAI000712Transcriptional control of herpes simplex virus lytic infection and latency-reactivation cycles72025
R01CA200709Facilitated recruitment of MYC to chromatin by interaction with WDR562025
ZIADK075017Epigenomic regulation of adipogenesis and obesity-associated adipose expansion62025
P30CA015704Cancer Center Support Grant52025

1 to 10 of 1,845Source NIH's project files

See all 1,845 nih grants

Papers2,264

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Analysis of Rare Coding Variation Identifies New Genetic Contributors to Schizophrenia.bioRxiv202642818077PubTator, text miningPubMed
Crosstalk between NUAK1 and the SETD1A complex regulates glycolysis and gluconeogenesis upon glucose deprivation.J Biol Chem202642778105PubTator, text miningPubMed
Reliability of Specific High-Intensity Interval Exercise Protocol for Judo Athletes.Int J Sports Physiol Perform202642772724PubTator, text miningPubMed
Reorientation of the SUMOylation landscape and altered L3mbtl2-mediated transcriptional activity in cancer-associated muscle contractile dysfunction.Cell Death Discov202642717202PubTator, text miningPubMed
Early-Onset Epilepsy with Developmental Delay - A Novel C.1640A>C Mutation in the SETD1A Gene with Sensorineural Hearing Loss.Neurol India202642700128PubTator, text miningPubMed
Effects of resistance training sets on cognition and brain-derived neurotrophic factor in cognitively impaired individuals: a quasi-experimental study.J Gerontol A Biol Sci Med Sci202642678372PubTator, text miningPubMed
Variable Expressiveness of a Novel Pathogenic SETD1A Missense Variant Linked to FLOS Domain Haploinsufficiency in a Mexican Pedigree.Diseases202642645097PubTator, text miningPubMed
Tracing the origins of de novo coronary collateral formation in cardiac repair.Science202642623479PubTator, text miningPubMed
Retraction Note: Histone methyltransferase SETD1A interacts with notch and promotes notch transactivation to augment ovarian cancer development.BMC Cancer202642601603PubTator, text miningPubMed
The Bcl11-Cxxc1 axis regulates stage-specific chromatin accessibility during lymphocyte development.Genes Dev202642547288PubTator, text miningPubMed

1 to 10 of 2,264

See all 2,264 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9739

GET https://conductscience.org/api/genes/v1/9739/patents