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Gene · 9757

KMT2B: lysine methyltransferase 2B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KMT2B: lysine methyltransferase 2B. Genes, record 9757. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9757

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Gene

Symbol
KMT2B
HGNC
Name
lysine methyltransferase 2B
HGNC
NCBI Gene ID
9757
NCBI Gene
HGNC ID
HGNC:15840
HGNC
Ensembl
ENSG00000272333
NCBI Gene
Aliases
CXXC10, DYT28, HRX2, KIAA0304, MLL1B, MLL2, MLL4, MRD68, TRX2, WBP-7, WBP7
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UMN6Histone-lysine N-methyltransferase 2B2,7154Ensembl, GeneID, HGNC

Source UniProt

Patents38

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2025238176 A12025-11-203Q9UMN6Espacenet
EP 4650780 A22025-11-1912934Q9UMN6Espacenet
EP 4641201 A22025-10-2914496Q9UMN6Espacenet
JP 2025147176 A2025-10-0615225Q9UMN6Espacenet
JP 2025517969 A2025-06-1214496Q9UMN6Espacenet
JP 2025517970 A2025-06-1212934Q9UMN6Espacenet
JP 2025028160 A2025-02-2815225Q9UMN6Espacenet
KR 1020250010750 A2025-01-2115225Q9UMN6Espacenet
JP 2024109657 A2024-08-1415064Q9UMN6Espacenet
US 11807852 B22023-11-0750Q9UMN6Espacenet

1 to 10 of 38

See all 38 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,082

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKMT2B papersNewest fiscal year
P30CA008748Cancer Center Support Grant532025
P30CA016672Cancer Center Support Grant452025
ZIADK075003Enhancer regulation by H3K4 methyltransferase KMT2D/MLL4 and associated factors212025
R35CA197569Mutations of Chromatin and its Modifying Machineries in Malignancies172025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center122025
UL1TR001863Yale Clinical and Translational Science Award112025
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias102025
P30CA006973Regional Oncology Research Center102025
P30CA021765Cancer Center Support Grant (CCSG)102025
ZIADK075017Epigenomic regulation of adipogenesis and obesity-associated adipose expansion102025

1 to 10 of 2,082Source NIH's project files

See all 2,082 nih grants

Papers2,805

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Nanopore long-read sequencing facilitates accurate diagnosis of KMT2B-related dystonia.Clin Epigenetics202642754922PubTator, text miningPubMed
[Genetic Dystonias].Medicina (B Aires)202642659549PubTator, text miningPubMed
Chromatin condensates tune nuclear mechanosensing and preserve nuclear integrity to prevent cGAS activation.EMBO J202642587091PubTator, text miningPubMed
BAP1 and UTX are dispensable for transcription-driven Polycomb erasure but essential for enhancer establishment.J Biol Chem202642567521PubTator, text miningPubMed
Rare-Variant Burden Analysis of Dystonia Genes in Parkinson's Disease.Mov Disord202642541459PubTator, text miningPubMed
Correction: Central precocious puberty as the initial manifestation of multisystem involvement caused by de novo heterozygous KMT2B mutation and STS hemizygous deletion: a case report.Front Endocrinol (Lausanne)202642488006PubTator, text miningPubMed
Genetic analysis of childhood-onset dystonia-28 caused by a variant (c.5076G>A) in the KMT2B gene.Glob Med Genet202642440406PubTator, text miningPubMed
Central precocious puberty as the initial manifestation of multisystem involvement caused by de novo heterozygous KMT2B mutation and STS hemizygous deletion: a case report.Front Endocrinol (Lausanne)202642388856PubTator, text miningPubMed
Prohibitins in cancer: Multifaceted regulators of mitochondrial homeostasis, oncogenic signaling, tumor microenvironment, and therapeutic resistance.Cancer Genet202642341379PubTator, text miningPubMed
Diagnostic value of genetic testing in chorea: a retrospective monocentric study.J Neurol202642321428PubTator, text miningPubMed

1 to 10 of 2,805

See all 2,805 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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