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HDAC4: histone deacetylase 4

1 protein, 19 patents, 12 drugs, 389 trials, 3,239 NIH grants and 5,550 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHDAC4HGNC
Namehistone deacetylase 4HGNC
NCBI Gene ID9759NCBI Gene
HGNC IDHGNC:14063HGNC
EnsemblENSG00000068024NCBI Gene
AliasesAHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, KIAA0288, NEDCHF, NEDCHIDNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P56524Histone deacetylase 41,08419Ensembl, GeneID, HGNCUniProt

Patents 19

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4667578 A22025-12-24228P56524Espacenet
EP 4641201 A22025-10-291944P56524Espacenet
JP 2025131621 A2025-09-09228P56524Espacenet
JP 2025517969 A2025-06-121944P56524Espacenet
JP 2024123008 A2024-09-106464P56524Espacenet
JP 2023510565 A2023-03-14399P56524Espacenet
US 11446398 B22022-09-2038594P56524Espacenet
JP 2022524081 A2022-04-27141565P56524Espacenet
JP 2022521851 A2022-04-12228P56524Espacenet
US 11078247 B22021-08-034906P56524Espacenet

Drugs 12

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABEXINOSTATCHEMBL2103863Histone deacetylase inhibitorINHIBITORChEMBL
BELINOSTATCHEMBL408513Histone deacetylase inhibitorINHIBITORChEMBL
CUDC-101CHEMBL598797Histone deacetylase inhibitorINHIBITORChEMBL
ENTINOSTATCHEMBL27759Histone deacetylase inhibitorINHIBITORChEMBL
FIMEPINOSTATCHEMBL3622533Histone deacetylase inhibitorINHIBITORChEMBL
GIVINOSTATCHEMBL1213492Histone deacetylase inhibitorINHIBITORChEMBL
GIVINOSTAT HYDROCHLORIDECHEMBL6068400Histone deacetylase inhibitorINHIBITORChEMBL
PANOBINOSTATCHEMBL483254Histone deacetylase inhibitorINHIBITORChEMBL
PANOBINOSTAT LACTATECHEMBL3545368Histone deacetylase inhibitorINHIBITORChEMBL
QUISINOSTATCHEMBL2105763Histone deacetylase inhibitorINHIBITORChEMBL

Trials 389

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07492394ENTINOSTATPHASE2ClinicalTrials.gov
NCT07441486ENTINOSTATPHASE2ClinicalTrials.gov
NCT07330544ENTINOSTATPHASE2ClinicalTrials.gov
NCT07261592ENTINOSTATPHASE1/PHASE2ClinicalTrials.gov
NCT07235618ENTINOSTATPHASE2ClinicalTrials.gov
NCT06824662QUISINOSTATEARLY_PHASE1ClinicalTrials.gov
NCT06769633GIVINOSTAT HYDROCHLORIDEPHASE2ClinicalTrials.gov
NCT06561048BELINOSTATPHASE3ClinicalTrials.gov
NCT06406465BELINOSTATPHASE2ClinicalTrials.gov
NCT06240520PANOBINOSTATPHASE1/PHASE2ClinicalTrials.gov

NIH grants 3239

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant202,025NIH's project files
R01GM049758Structure and Function of Metalloenzymes172,025NIH's project files
P30CA006973Regional Oncology Research Center122,025NIH's project files
P30CA008748Cancer Center Support Grant112,025NIH's project files
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant72,025NIH's project files
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)72,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award62,025NIH's project files
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes52,025NIH's project files
P30CA014195Cancer Center Support Grant (CCSG)52,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant52,025NIH's project files

Papers 5550

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42773415PubTator, text miningPubMed
42715958PubTator, text miningPubMed
42697879PubTator, text miningPubMed
42652188PubTator, text miningPubMed
42644057PubTator, text miningPubMed
42636425PubTator, text miningPubMed
42624563PubTator, text miningPubMed
42617273PubTator, text miningPubMed
42586752PubTator, text miningPubMed
42576627PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license