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Gene · 976

ADGRE5: adhesion G protein-coupled receptor E5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ADGRE5: adhesion G protein-coupled receptor E5. Genes, record 976. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/976

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Gene

Symbol
ADGRE5
HGNC
Name
adhesion G protein-coupled receptor E5
HGNC
NCBI Gene ID
976
NCBI Gene
HGNC ID
HGNC:1711
HGNC
Ensembl
ENSG00000123146
NCBI Gene
Aliases
CD97, TM7LN1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P48960Adhesion G protein-coupled receptor E58359Ensembl, GeneID, HGNC

Source UniProt

Patents51

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1440659P48960Espacenet
EP 4650780 A22025-11-191072P48960Espacenet
EP 4641201 A22025-10-29751P48960Espacenet
JP 2025147176 A2025-10-06438P48960Espacenet
JP 2025529142 A2025-09-04306P48960Espacenet
JP 2025529142 A2025-09-045412P48960Espacenet
US 12371689 B22025-07-29306P48960Espacenet
US 12371689 B22025-07-295412P48960Espacenet
JP 2025517969 A2025-06-12751P48960Espacenet
JP 2025517970 A2025-06-121072P48960Espacenet

1 to 10 of 51

See all 51 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants590

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleADGRE5 papersNewest fiscal year
P30CA008748Cancer Center Support Grant32025
P30CA016087Cancer Center Support Grant32025
P30CA021765Cancer Center Support Grant (CCSG)32025
R01AI040098B lymphocyte Migration and Homeostasis32025
R01NS124920Developmentally Regulated Enhancers and Chromatin Architecture in Human Neurogenesis32025
P30CA015704Cancer Center Support Grant22025
P51OD011104Tulane National Primate Research Center22025
R01CA251669Adhesion GPCR regulation of acute myeloid leukemia stem cells - Resubmission - 122025
UL1TR001445Clinical and Translational Science Award22025
ZICBC010947Laboratory of Cancer Biology and Genetics Microscopy Core Facility22025

1 to 10 of 590Source NIH's project files

See all 590 nih grants

Papers951

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Efferocytosis triggered proteomic reprogramming of macrophages reveals CD97 as a novel apoptotic receptor.Cell Death Differ202642811049PubTator, text miningPubMed
CD97/ADGRE5 in Cancer: Structural Activation, Context-Dependent Signaling, and Therapeutic Targeting.Cells202642738898PubTator, text miningPubMed
CD55 organizes lipid raft-LCK signaling to potentiate NK-cell antitumor immunity.Cell Res202642693249PubTator, text miningPubMed
Multi-Omics Integration Reveals That SN-011 Targets JUNB to Upregulate ADGRE5 and Restore Vascular Endothelial Cell Communication in Ischemic Stroke.Chem Biol Drug Des202642549987PubTator, text miningPubMed
Overexpression of CD97 in intestinal epithelial cells attenuates LPS-induced pro-inflammatory cytokine induction via stabilization of β-catenin early in life.PLoS One202642531273PubTator, text miningPubMed
A spatially organized immune-stromal program drives the fissure-to-fistula continuum in Crohn's disease.J Crohns Colitis202642522256PubTator, text miningPubMed
Immune regulation by CD55 in chronic beryllium disease.Am J Respir Cell Mol Biol202642089302PubTator, text miningPubMed
Advances in the mechanisms of extracellular vesicles and circulating tumor cells in hepatocellular carcinoma metastasis (Review).Mol Med Rep202641930461PubTator, text miningPubMed
Single-cell insights into trophoblast heterogeneity and adaptive dysfunction in selective fetal growth restriction.Commun Biol202641845016PubTator, text miningPubMed
Preclinical advances and mechanistic insights of CAR-T therapy for acute myeloid leukemia: from target iteration to microenvironment regulation.Ann Med202641800605PubTator, text miningPubMed

1 to 10 of 951

See all 951 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/976

GET https://conductscience.org/api/genes/v1/976/patents?page=2