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Gene · 9775

EIF4A3: eukaryotic translation initiation factor 4A3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EIF4A3: eukaryotic translation initiation factor 4A3. Genes, record 9775. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9775

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Gene

Symbol
EIF4A3
HGNC
Name
eukaryotic translation initiation factor 4A3
HGNC
NCBI Gene ID
9775
NCBI Gene
HGNC ID
HGNC:18683
HGNC
Ensembl
ENSG00000141543
NCBI Gene
Aliases
DDX48, EIF4AIII, Fal1, KIAA0111, MUK34, NMP265, NUK34, RCPS, eIF-4A-III, eIF4A-III, eIF4AIII
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P38919Eukaryotic initiation factor 4A-III41122Ensembl, GeneID, HGNC

Source UniProt

Patents54

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1919634P38919Espacenet
EP 4641201 A22025-10-2925415P38919Espacenet
JP 2025517969 A2025-06-1225415P38919Espacenet
JP 2025517970 A2025-06-1219634P38919Espacenet
JP 2025514983 A2025-05-1312P38919Espacenet
JP 2025032204 A2025-03-1127713P38919Espacenet
EP 4461818 A22024-11-1327713P38919Espacenet
US 11694765 B22023-07-04144P38919Espacenet
US 11694765 B22023-07-04250P38919Espacenet
JP 2023058610 A2023-04-2527713P38919Espacenet

1 to 10 of 54

See all 54 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants818

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEIF4A3 papersNewest fiscal year
P20GM121176Autophagy, Inflammation and Metabolism (AIM) in Disease Center - Phase 2.52025
P30AI027763UCSF-Bay Area Center for AIDS Research42025
P30CA008748Cancer Center Support Grant42025
P30CA045508CSHL Cancer Center Support Grant42025
P01CA125066Discovery of Anticancer Agents of Diverse Natural Origin32025
P30CA015704Cancer Center Support Grant32025
P30CA016058Cancer Center Support Grant32025
P30CA016086Cancer Center Support Grant32025
P30CA016672Cancer Center Support Grant32025
R01GM042699Biochemistry of Pre-mRNA Splicing32025

1 to 10 of 818Source NIH's project files

See all 818 nih grants

Papers1,749

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Statement of Retraction: Circ 003390/Eukaryotic translation initiation factor 4A3 promoted cell migration and proliferation in endometrial cancer via vascular endothelial growth factor signaling by miR-195-5p.
Bioengineered202642821798PubTator, text miningPubMed
[Inhibition of RBM5 expression by the interaction between hsa_circ_0006200 and EIF4A3 and its impact on cervical cancer progression].Zhonghua Fu Chan Ke Za Zhi202642802115PubTator, text miningPubMed
EIF4A3-mediated downregulation of circ_0073586 promotes cadmium-induced lung carcinogenesis through SRSF9-triggered GPX4-dependent ferroptosis resistance.Ecotoxicol Environ Saf202642641444PubTator, text miningPubMed
Single-cell transcriptomics reveals a correlation between inflammatory C7 fibroblasts in cervical tumor-adjacent normal tissues and cervical cancer progression.Front Cell Dev Biol202642638795PubTator, text miningPubMed
Assembly of exon junction complexes on spliceosomes begins before spliceosome activation.Nucleic Acids Res202642635127PubTator, text miningPubMed
Transcriptomic landscape of human circular RNAs: unveiling molecular mechanisms in high-altitude adaptation.Front Genet202642634741PubTator, text miningPubMed
Pervasive noise in human pre-mRNA splice site selection.Mol Cell202642607686PubTator, text miningPubMed
Pathophysiological and translational implications of the dysregulation of molecular machineries controlling RNA metabolism in thyrotropinomas.iScience202642602702PubTator, text miningPubMed
Lactylation of EIF4A3 mediates sustained circPTK2 biogenesis to drive prostate cancer metastasis.Cancer Lett202642595075PubTator, text miningPubMed
EIF4A3-dependent nonsense-mediated decay buffers AML1-ETO9a dosage and modulates outcome in t(8;21) acute myeloid leukemia.Leukemia202642448936PubTator, text miningPubMed

1 to 10 of 1,749

See all 1,749 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9775

GET https://conductscience.org/api/genes/v1/9775/patents?page=2