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Gene · 9780

PIEZO1: piezo type mechanosensitive ion channel component 1 (Er blood group)

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PIEZO1: piezo type mechanosensitive ion channel component 1 (Er blood group). Genes, record 9780. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9780

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Gene

Symbol
PIEZO1
HGNC
Name
piezo type mechanosensitive ion channel component 1 (Er blood group)
HGNC
NCBI Gene ID
9780
NCBI Gene
HGNC ID
HGNC:28993
HGNC
Ensembl
ENSG00000103335
NCBI Gene
Aliases
DHS, ER, FAM38A, KIAA0233, LMPH3, LMPHM6, Mib
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92508Piezo-type mechanosensitive ion channel component 12,5216Ensembl, GeneID, HGNC

Source UniProt

Patents30

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-194036Q92508Espacenet
EP 4641201 A22025-10-293612Q92508Espacenet
JP 2025529142 A2025-09-043468Q92508Espacenet
WO 2025164642 A2025-08-071Q92508Espacenet
US 12371689 B22025-07-293468Q92508Espacenet
JP 2025517969 A2025-06-123612Q92508Espacenet
JP 2025517970 A2025-06-124036Q92508Espacenet
US 12178902 B12024-12-312Q92508Espacenet
US 12172037 B22024-12-242Q92508Espacenet
US 12163192 B22024-12-104Q92508Espacenet

1 to 10 of 30

See all 30 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,590

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePIEZO1 papersNewest fiscal year
P30AR073752Washington University Rheumatic Diseases Research Resource-based Center92025
P30AR074992RESOURCE BASED CENTER FOR MUSCULOSKELETAL BIOLOGY AND MEDICINE92025
R01GM130834PHARMACOLOGICAL MODULATION OF PIEZO1 CHANNELS92025
R01HL121365Integration of single-cell imaging and multi-omics sequencing to study EC mechano-pathophysiology92025
R01AR080902Genetically-engineered stem cells for self-regulating arthritis therapy82025
R35NS105067Mechanisms of force sensing in the nervous system72025
T32NS082174Training Program in Stem Cell Translational Medicine for Neurological Disorders72025
K12HD001262Women's Reproductive Health Research52025
P30CA008748Cancer Center Support Grant52025
P30EY005722Center Core Grant for Vision Research52025

1 to 10 of 1,590Source NIH's project files

See all 1,590 nih grants

Papers3,250

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Mechanosensitive ion channels in intestinal homeostasis and disease.eGastroenterology202642824911PubTator, text miningPubMed
Brain endothelial homeostasis in psychiatric disorders: mechanisms, evidence, and translational opportunities.Front Cell Neurosci202642819782PubTator, text miningPubMed
Operationalizing perioperative clearance reserve: a reserve-load interaction model for neurocognitive outcomes in older surgical patients.Front Med (Lausanne)202642819353PubTator, text miningPubMed
Sex differences in the genetic architecture of clinical quantitative traits in the electronic health record.medRxiv202642818419PubTator, text miningPubMed
Prepatterned Tissue Stiffness Gradient Controls Organ shape and size.bioRxiv202642818297PubTator, text miningPubMed
Starvation improves epithelial fitness by selectively extruding DNA damaged cells.bioRxiv202642817929PubTator, text miningPubMed
Shear Stress-Stimulated Trafficking of Endothelial Piezo1 to Splenic Capsule Boosts Spleen Contraction and Exercise Endurance.J Extracell Vesicles202642804736PubTator, text miningPubMed
Single-cell and bulk transcriptomic integration identifies a high-CNV, dark-zone-enriched malignant cell state associated with adverse prognosis in GCB-DLBCL.Hematology202642803950PubTator, text miningPubMed
Advanced Glycation End Products and Metabolic-Mechanical Coupling in Diabetic Retinopathy.Clin Ophthalmol202642799218PubTator, text miningPubMed
Mechanisms of Piezo1-Mediated Mechanotransduction in Thrombotic Diseases.Int J Mol Sci202642794532PubTator, text miningPubMed

1 to 10 of 3,250

See all 3,250 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9780

GET https://conductscience.org/api/genes/v1/9780/patents?page=2