Gene · 9780
PIEZO1: piezo type mechanosensitive ion channel component 1 (Er blood group)
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PIEZO1: piezo type mechanosensitive ion channel component 1 (Er blood group). Genes, record 9780. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9780
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q92508 | Piezo-type mechanosensitive ion channel component 1 | 2,521 | 6 | Ensembl, GeneID, HGNC |
Source UniProt
Patents30
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 4036 | Q92508 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 3612 | Q92508 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3468 | Q92508 | Espacenet |
| WO 2025164642 A | 2025-08-07 | 1 | Q92508 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3468 | Q92508 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 3612 | Q92508 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4036 | Q92508 | Espacenet |
| US 12178902 B1 | 2024-12-31 | 2 | Q92508 | Espacenet |
| US 12172037 B2 | 2024-12-24 | 2 | Q92508 | Espacenet |
| US 12163192 B2 | 2024-12-10 | 4 | Q92508 | Espacenet |
1 to 10 of 30
See all 30 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,590
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PIEZO1 papers | Newest fiscal year |
|---|---|---|---|
| P30AR073752 | Washington University Rheumatic Diseases Research Resource-based Center | 9 | 2025 |
| P30AR074992 | RESOURCE BASED CENTER FOR MUSCULOSKELETAL BIOLOGY AND MEDICINE | 9 | 2025 |
| R01GM130834 | PHARMACOLOGICAL MODULATION OF PIEZO1 CHANNELS | 9 | 2025 |
| R01HL121365 | Integration of single-cell imaging and multi-omics sequencing to study EC mechano-pathophysiology | 9 | 2025 |
| R01AR080902 | Genetically-engineered stem cells for self-regulating arthritis therapy | 8 | 2025 |
| R35NS105067 | Mechanisms of force sensing in the nervous system | 7 | 2025 |
| T32NS082174 | Training Program in Stem Cell Translational Medicine for Neurological Disorders | 7 | 2025 |
| K12HD001262 | Women's Reproductive Health Research | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P30EY005722 | Center Core Grant for Vision Research | 5 | 2025 |
1 to 10 of 1,590Source NIH's project files
See all 1,590 nih grantsPapers3,250
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Mechanosensitive ion channels in intestinal homeostasis and disease. | eGastroenterology | 2026 | 42824911 | PubTator, text mining | PubMed |
| Brain endothelial homeostasis in psychiatric disorders: mechanisms, evidence, and translational opportunities. | Front Cell Neurosci | 2026 | 42819782 | PubTator, text mining | PubMed |
| Operationalizing perioperative clearance reserve: a reserve-load interaction model for neurocognitive outcomes in older surgical patients. | Front Med (Lausanne) | 2026 | 42819353 | PubTator, text mining | PubMed |
| Sex differences in the genetic architecture of clinical quantitative traits in the electronic health record. | medRxiv | 2026 | 42818419 | PubTator, text mining | PubMed |
| Prepatterned Tissue Stiffness Gradient Controls Organ shape and size. | bioRxiv | 2026 | 42818297 | PubTator, text mining | PubMed |
| Starvation improves epithelial fitness by selectively extruding DNA damaged cells. | bioRxiv | 2026 | 42817929 | PubTator, text mining | PubMed |
| Shear Stress-Stimulated Trafficking of Endothelial Piezo1 to Splenic Capsule Boosts Spleen Contraction and Exercise Endurance. | J Extracell Vesicles | 2026 | 42804736 | PubTator, text mining | PubMed |
| Single-cell and bulk transcriptomic integration identifies a high-CNV, dark-zone-enriched malignant cell state associated with adverse prognosis in GCB-DLBCL. | Hematology | 2026 | 42803950 | PubTator, text mining | PubMed |
| Advanced Glycation End Products and Metabolic-Mechanical Coupling in Diabetic Retinopathy. | Clin Ophthalmol | 2026 | 42799218 | PubTator, text mining | PubMed |
| Mechanisms of Piezo1-Mediated Mechanotransduction in Thrombotic Diseases. | Int J Mol Sci | 2026 | 42794532 | PubTator, text mining | PubMed |
1 to 10 of 3,250
See all 3,250 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9780
GET https://conductscience.org/api/genes/v1/9780/patents?page=2