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KEAP1: kelch like ECH associated protein 1

1 protein, 47 patents, 4 drugs, 110 trials, 5,085 NIH grants and 17,242 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolKEAP1HGNC
Namekelch like ECH associated protein 1HGNC
NCBI Gene ID9817NCBI Gene
HGNC IDHGNC:23177HGNC
EnsemblENSG00000079999NCBI Gene
AliasesINrf2, KIAA0132, KLHL19, MGC10630, MGC1114, MGC20887, MGC4407, MGC9454NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q14145Kelch-like ECH-associated protein 1624122Ensembl, GeneID, HGNCUniProt

Patents 47

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1450647Q14145Espacenet
JP 2026004568 A2026-01-1450648Q14145Espacenet
EP 4650780 A22025-11-19145Q14145Espacenet
EP 4641201 A22025-10-29115Q14145Espacenet
JP 2025534334 A2025-10-151Q14145Espacenet
EP 4594308 A12025-08-061Q14145Espacenet
JP 2025517969 A2025-06-12115Q14145Espacenet
JP 2025517970 A2025-06-12145Q14145Espacenet
KR 1020250075677 A2025-05-281Q14145Espacenet
WO 2025101862 A12025-05-1532Q14145Espacenet

Drugs 4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BARDOXOLONE METHYLCHEMBL1762621Keap1/Nrf2 inhibitorINHIBITORChEMBL
DIMETHYL FUMARATECHEMBL2107333Kelch-like ECH-associated protein 1 inhibitorINHIBITORChEMBL
DIROXIMEL FUMARATECHEMBL3989944Kelch-like ECH-associated protein 1 inhibitorINHIBITORChEMBL
MONOMETHYL FUMARATECHEMBL589586Kelch-like ECH-associated protein 1 inhibitorINHIBITORChEMBL

Trials 110

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07548996DIMETHYL FUMARATEPHASE2/PHASE3ClinicalTrials.gov
NCT07483632DIMETHYL FUMARATEPHASE3ClinicalTrials.gov
NCT07483632DIROXIMEL FUMARATEPHASE3ClinicalTrials.gov
NCT07258394DIMETHYL FUMARATEPHASE3ClinicalTrials.gov
NCT07189325DIMETHYL FUMARATEPHASE3ClinicalTrials.gov
NCT07138833DIMETHYL FUMARATEPHASE4ClinicalTrials.gov
NCT06957808DIROXIMEL FUMARATEClinicalTrials.gov
NCT06850597DIMETHYL FUMARATEPHASE2ClinicalTrials.gov
NCT06662227MONOMETHYL FUMARATEEARLY_PHASE1ClinicalTrials.gov
NCT06513533DIMETHYL FUMARATEPHASE2/PHASE3ClinicalTrials.gov

NIH grants 5085

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1042,025NIH's project files
P30CA016672Cancer Center Support Grant832,025NIH's project files
P30ES006694Southwest Environmental Health Sciences Center712,025NIH's project files
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)382,025NIH's project files
T32ES007091Training in Environmental Toxicology of Human Disease252,025NIH's project files
P30ES013508Center of Excellence in Environmental Toxicology222,025NIH's project files
P30CA006973Regional Oncology Research Center212,025NIH's project files
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant202,025NIH's project files
P30CA072720Cancer Center Support Grant202,025NIH's project files
P42ES004940The DUST Center: Hazardous Dust in Drylands - Exposure, Health Impacts, and Mitigation182,025NIH's project files

Papers 17242

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826199PubTator, text miningPubMed
42824186PubTator, text miningPubMed
42820248PubTator, text miningPubMed
42818246PubTator, text miningPubMed
42813279PubTator, text miningPubMed
42812565PubTator, text miningPubMed
42802387PubTator, text miningPubMed
42801944PubTator, text miningPubMed
42800566PubTator, text miningPubMed
42797696PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license