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Gene · 9833

MELK: maternal embryonic leucine zipper kinase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MELK: maternal embryonic leucine zipper kinase. Genes, record 9833. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9833

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Gene

Symbol
MELK
HGNC
Name
maternal embryonic leucine zipper kinase
HGNC
NCBI Gene ID
9833
NCBI Gene
HGNC ID
HGNC:16870
HGNC
Ensembl
ENSG00000165304
NCBI Gene
Aliases
HPK38, KIAA0175
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14680Maternal embryonic leucine zipper kinase65132Ensembl, GeneID, HGNC

Source UniProt

Patents102

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1452689Q14680Espacenet
EP 4650780 A22025-11-193858Q14680Espacenet
EP 4641201 A22025-10-293425Q14680Espacenet
EP 4641202 A22025-10-29201Q14680Espacenet
JP 2025529142 A2025-09-042596Q14680Espacenet
US 12371689 B22025-07-292596Q14680Espacenet
JP 2025517969 A2025-06-123425Q14680Espacenet
JP 2025517970 A2025-06-123858Q14680Espacenet
KR 1020250017231 A2025-02-04201Q14680Espacenet
US 11827937 B22023-11-2877Q14680Espacenet

1 to 10 of 102

See all 102 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants639

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMELK papersNewest fiscal year
P30CA016672Cancer Center Support Grant82025
P01CA163205Circumventing Barriers to Effective Oncolytic Virotherapy of Malignant Gliomas52025
P40OD010440Caenorhabditis Genetics Center52025
P30CA016058Cancer Center Support Grant42025
P30CA016086Cancer Center Support Grant42025
P50CA127001SPORE in Brain Cancer42025
P30CA008748Cancer Center Support Grant32025
P30CA014599Cancer Center Support Grant32025
P30CA030199Cancer Center Support Grant (CCSG)32025
P30CA045508CSHL Cancer Center Support Grant32025

1 to 10 of 639Source NIH's project files

See all 639 nih grants

Papers1,515

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Prognostic significance of the MELK/TMPO-AS1/hsa-let-7b-5p network in lung adenocarcinoma.Front Oncol202642741133PubTator, text miningPubMed
In Silico Evaluation of Annonaceous Acetogenins as Potential HER2 and MELK Inhibitors for Targeted Cancer Therapy.Anticancer Agents Med Chem202642708335PubTator, text miningPubMed
EIF1 coordinates transcriptomic and splicing networks associated with cell cycle dysregulation in diabetic retinopathy.PLoS One202642691050PubTator, text miningPubMed
Corrigendum to "Oleandrin-mediated suppression of MELK induces apoptosis, autophagy, and ferroptosis in human non-small cell lung cancer cells" [Phytomedicine. 2025 Nov;147:157173].Phytomedicine202642603768PubTator, text miningPubMed
Investigation of novel 4-substituted piperazine-pyrrolo[2,3-d]pyrimidine N-phenylacetamides as MELK-targeted anticancer agents for breast cancer therapy.Bioorg Chem202642497764PubTator, text miningPubMed
Unveiling immune-related gene signatures in triple negative breast cancer through integrated transcriptomic analysis.Biomedicine (Taipei)202642483440PubTator, text miningPubMed
An Exploratory Transcriptomic Classification Model for Psoriasis Based on Apoptosis-Associated and Proliferation-Apoptosis-Coupled Genes Using Explainable Machine Learning.Int J Mol Sci202642353157PubTator, text miningPubMed
Vernodalin and Gymnanthemum extensum Crude Extracts Exhibit In Vitro Anticancer Activity with Differential Regulation of Cancer-Associated Signaling Proteins in Breast and Ovarian Cancer Cells.Biomedicines202642351758PubTator, text miningPubMed
Phosphosite-specific co-regulation networks of MELK kinase: insights from integrative global phosphoproteomes.J Genet Eng Biotechnol202642309608PubTator, text miningPubMed
MELK inhibits cuproptosis in diffuse large B-cell lymphoma cells via the PI3K/mTOR/S6K-DLAT signaling axis.Mol Cell Biochem202642228272PubTator, text miningPubMed

1 to 10 of 1,515

See all 1,515 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9833

GET https://conductscience.org/api/genes/v1/9833/patents?page=2