Gene · 9833
MELK: maternal embryonic leucine zipper kinase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MELK: maternal embryonic leucine zipper kinase. Genes, record 9833. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9833
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q14680 | Maternal embryonic leucine zipper kinase | 651 | 32 | Ensembl, GeneID, HGNC |
Source UniProt
Patents102
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 52689 | Q14680 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 3858 | Q14680 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 3425 | Q14680 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 201 | Q14680 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2596 | Q14680 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2596 | Q14680 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 3425 | Q14680 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 3858 | Q14680 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 201 | Q14680 | Espacenet |
| US 11827937 B2 | 2023-11-28 | 77 | Q14680 | Espacenet |
1 to 10 of 102
See all 102 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants639
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MELK papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| P01CA163205 | Circumventing Barriers to Effective Oncolytic Virotherapy of Malignant Gliomas | 5 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 5 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 4 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 4 | 2025 |
| P50CA127001 | SPORE in Brain Cancer | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA014599 | Cancer Center Support Grant | 3 | 2025 |
| P30CA030199 | Cancer Center Support Grant (CCSG) | 3 | 2025 |
| P30CA045508 | CSHL Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 639Source NIH's project files
See all 639 nih grantsPapers1,515
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Prognostic significance of the MELK/TMPO-AS1/hsa-let-7b-5p network in lung adenocarcinoma. | Front Oncol | 2026 | 42741133 | PubTator, text mining | PubMed |
| In Silico Evaluation of Annonaceous Acetogenins as Potential HER2 and MELK Inhibitors for Targeted Cancer Therapy. | Anticancer Agents Med Chem | 2026 | 42708335 | PubTator, text mining | PubMed |
| EIF1 coordinates transcriptomic and splicing networks associated with cell cycle dysregulation in diabetic retinopathy. | PLoS One | 2026 | 42691050 | PubTator, text mining | PubMed |
| Corrigendum to "Oleandrin-mediated suppression of MELK induces apoptosis, autophagy, and ferroptosis in human non-small cell lung cancer cells" [Phytomedicine. 2025 Nov;147:157173]. | Phytomedicine | 2026 | 42603768 | PubTator, text mining | PubMed |
| Investigation of novel 4-substituted piperazine-pyrrolo[2,3-d]pyrimidine N-phenylacetamides as MELK-targeted anticancer agents for breast cancer therapy. | Bioorg Chem | 2026 | 42497764 | PubTator, text mining | PubMed |
| Unveiling immune-related gene signatures in triple negative breast cancer through integrated transcriptomic analysis. | Biomedicine (Taipei) | 2026 | 42483440 | PubTator, text mining | PubMed |
| An Exploratory Transcriptomic Classification Model for Psoriasis Based on Apoptosis-Associated and Proliferation-Apoptosis-Coupled Genes Using Explainable Machine Learning. | Int J Mol Sci | 2026 | 42353157 | PubTator, text mining | PubMed |
| Vernodalin and Gymnanthemum extensum Crude Extracts Exhibit In Vitro Anticancer Activity with Differential Regulation of Cancer-Associated Signaling Proteins in Breast and Ovarian Cancer Cells. | Biomedicines | 2026 | 42351758 | PubTator, text mining | PubMed |
| Phosphosite-specific co-regulation networks of MELK kinase: insights from integrative global phosphoproteomes. | J Genet Eng Biotechnol | 2026 | 42309608 | PubTator, text mining | PubMed |
| MELK inhibits cuproptosis in diffuse large B-cell lymphoma cells via the PI3K/mTOR/S6K-DLAT signaling axis. | Mol Cell Biochem | 2026 | 42228272 | PubTator, text mining | PubMed |
1 to 10 of 1,515
See all 1,515 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9833
GET https://conductscience.org/api/genes/v1/9833/patents?page=2