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Gene · 9842

PLEKHM1: pleckstrin homology and RUN domain containing M1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PLEKHM1: pleckstrin homology and RUN domain containing M1. Genes, record 9842. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9842

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Gene

Symbol
PLEKHM1
HGNC
Name
pleckstrin homology and RUN domain containing M1
HGNC
NCBI Gene ID
9842
NCBI Gene
HGNC ID
HGNC:29017
HGNC
Ensembl
ENSG00000225190
NCBI Gene
Aliases
AP162, B2, KIAA0356, OPTA3, OPTB6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y4G2Pleckstrin homology domain-containing family M member 11,0565Ensembl, GeneID, HGNC

Source UniProt

Patents21

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458202Q9Y4G2Espacenet
EP 4650780 A22025-11-1912347Q9Y4G2Espacenet
JP 2025517970 A2025-06-1212347Q9Y4G2Espacenet
US 11564998 B22023-01-319008Q9Y4G2Espacenet
US 11446398 B22022-09-2064180Q9Y4G2Espacenet
US 11446398 B22022-09-2064189Q9Y4G2Espacenet
US 11446398 B22022-09-2064190Q9Y4G2Espacenet
JP 2022524081 A2022-04-27167151Q9Y4G2Espacenet
JP 2022524081 A2022-04-27167160Q9Y4G2Espacenet
JP 2022524081 A2022-04-27167161Q9Y4G2Espacenet

1 to 10 of 21

See all 21 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,573

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePLEKHM1 papersNewest fiscal year
ZIAHD001607Protein Trafficking In The Endosomal-Lysosomal System72025
P30CA016056Roswell Park Cancer Center Support Grant52025
P30CA008748Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)42025
P30CA076292Moffitt Cancer Center Support Grant32025
ZIAAI000646Transgenic Animal Models Of Human Immune Defects32025
ZIAAI000647Genes And Gene Products As Immunoadjuvants32025
P20GM109036Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases22025
P30AG072975Rush Alzheimer's Disease Research Center22025

1 to 10 of 1,573Source NIH's project files

See all 1,573 nih grants

Papers1,359

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
RNF13 regulates the endolysosomal pathway through interaction with the small GTPase Arl8B.FEBS J202642206902PubTator, text miningPubMed
Risk genes in progressive supranuclear palsy (PSP) affect integrity and function of microtubules.Front Aging202642088849PubTator, text miningPubMed
RANKL-inducible Arl8b effector RUFY4 drives HOPS-mediated lysosomal maturation and trafficking in osteoclasts.Mol Biol Cell202641926340PubTator, text miningPubMed
Differential serum dynamics of apelin, elabela, and angiotensinogen in CKD and haemodialysis: insights into peptide modulation across the dialysis procedure.Ren Fail202641888034PubTator, text miningPubMed
Circulating cytokines mediate the risk of COPD: A mediation analysis based on 473 gut microbiota and 91 circulating cytokines.Medicine (Baltimore)202641861166PubTator, text miningPubMed
Shared genetic architecture between Parkinson's disease and self-reported sleep-related traits implicates the MAPT locus on chromosome 17.Sleep Adv202641822813PubTator, text miningPubMed
Role of autophagy in antiviral innate immunity.Cell Mol Biol Lett202641735833PubTator, text miningPubMed
The Contribution of Genetic Modifiers to Ovarian Cancer Risk in BRCA1 and BRCA2 Pathogenic Variant Carriers.Cancers (Basel)202641681824PubTator, text miningPubMed
Shared Pathogenic Pathways Between REM Sleep Behavior Disorder and Neurodegenerative and Psychiatric Disorders.medRxiv202641674635PubTator, text miningPubMed
Hypoxic mesenchymal stem cell-Derived Exosomal circPTP4A2 improves granulosa cell mitochondrial function via YBX1.Cell Mol Life Sci202641566072PubTator, text miningPubMed

1 to 10 of 1,359

See all 1,359 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9842

GET https://conductscience.org/api/genes/v1/9842/patents?page=2