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SETDB1: SET domain bifurcated histone lysine methyltransferase 1
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Gene · 9869

Papers2,616

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 2,616

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TitleJournalYearPMIDFound bySource
Lysine specific demethylase 5B promises to be a new focus of cancer drug-resistance: combination therapy.Biochim Biophys Acta Rev Cancer202642815836PubTator, text miningPubMed
USP4-Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC.Adv Sci (Weinh)202642811544PubTator, text miningPubMed
SETDB1 cooperates with the CRL4B complex to promote colorectal cancer tumorigenesis by disrupting circadian rhythm.Oncogene202642778664PubTator, text miningPubMed
The role of CHAMP1 in chromatin-mediated DNA damage repair.DNA Repair (Amst)202642748571PubTator, text miningPubMed
USP7/SETDB1 promotes non-small cell lung cancer progression by regulating ferroptosis via NRF2/SLC7A11/GPX4 axis.Gen Physiol Biophys202642717784PubTator, text miningPubMed
Beyond hypoxia and ccRCC: the expanding universe of VHL novel targets and next-generation therapeutics.Biomark Res202642717364PubTator, text miningPubMed
CTCF primes repressive chromatin for rapid BRCA1/BARD1 recruitment to drive homologous recombination repair of DNA double-strand breaks.Nucleic Acids Res202642475683PubTator, text miningPubMed
Setdb1 safeguards proper differentiation of adult intestinal stem cells by controlling chromatin accessibility and transcriptome variability.iScience202642472120PubTator, text miningPubMed
TRAF4 promotes nasopharyngeal carcinoma progression by stabilizing SETDB1 to suppress mitochondrial apoptosis.Mol Cell Biochem202642461470PubTator, text miningPubMed
Setdb1 represses antitumor immunity and tertiary lymphoid structures in hepatocellular carcinoma.J Hepatol202642457040PubTator, text miningPubMed
ALKBH5 is required to maintain proper SETDB1 protein levels associated with meiotic sex chromosome inactivation.Commun Biol202642443451PubTator, text miningPubMed
RNA sequencing identifies histone modification as a key mechanism of human periodontal ligament cell response to hydrostatic pressure.J Oral Biosci202642424660PubTator, text miningPubMed
SETDB1-mediated repression of RhoB promotes EMT and metastatic progression in prostate cancer.Oncogene202642420589PubTator, text miningPubMed
Chromatin chronicles: Unlocking the therapeutic potential of histone modifiers in hepatocellular carcinoma.Med Oncol202642360649PubTator, text miningPubMed
Author Correction: ATF7IP/SETDB1-mediated epigenetic programming regulates thymic homing and T lymphopoiesis of hematopoietic progenitors during embryogenesis.Nat Commun202642350413PubTator, text miningPubMed
Loss of PDL1 in mesenchymal stromal cells from young-onset MDS-RAEB-1 promotes inflamm-aging through epigenetic dysregulation of H3K9me3.Stem Cells Transl Med202642267703PubTator, text miningPubMed
Next generation technologies for CRISPR-based epigenome and transcriptional modulation.Curr Opin Biomed Eng202642266835PubTator, text miningPubMed
In Vitro Cell Viability and Migration Inhibitory Effects of Isorhamnetin in Non-Small Cell Lung Cancer Cells.Biomedicines202642193278PubTator, text miningPubMed
Targeted degradation of SETDB1 by an Aptamer-CRBNL PROTAC as a novel therapeutic strategy for breast cancer.Eur J Med Chem202642176657PubTator, text miningPubMed
Aberrant Expression of Human Endogenous Retroviruses and SETDB1 in Adolescents with Anorexia Nervosa.Int J Mol Sci202642123339PubTator, text miningPubMed

gene-search-2026-11-11-0.2.0

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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