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Gene · 9869

SETDB1: SET domain bifurcated histone lysine methyltransferase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SETDB1: SET domain bifurcated histone lysine methyltransferase 1. Genes, record 9869. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9869

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Gene

Symbol
SETDB1
HGNC
Name
SET domain bifurcated histone lysine methyltransferase 1
HGNC
NCBI Gene ID
9869
NCBI Gene
HGNC ID
HGNC:10761
HGNC
Ensembl
ENSG00000143379
NCBI Gene
Aliases
ESET, H3-K9-HMTase4, KG1T, KIAA0067, KMT1E, TDRD21
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15047Histone-lysine N-methyltransferase SETDB11,29126Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463300Q15047Espacenet
EP 4650780 A22025-11-192783Q15047Espacenet
EP 4641201 A22025-10-292348Q15047Espacenet
JP 2025529142 A2025-09-043916Q15047Espacenet
JP 2025527370 A2025-08-211Q15047Espacenet
US 12371689 B22025-07-293916Q15047Espacenet
JP 2025517969 A2025-06-122348Q15047Espacenet
JP 2025517970 A2025-06-122783Q15047Espacenet
EP 4555080 A12025-05-211Q15047Espacenet
JP 2025063201 A2025-04-1512Q15047Espacenet

1 to 10 of 23

See all 23 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,953

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSETDB1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant252025
P30CA016672Cancer Center Support Grant172025
P30CA010815Consolidated Basic Cancer Research Program132025
P30CA016086Cancer Center Support Grant102025
ZIAHD008933Mammalian Development and Evolution92025
T32CA009171Training Program in Basic Cancer Research62025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)52025
P30CA016087Cancer Center Support Grant52025
P40OD010440Caenorhabditis Genetics Center52025
UL1TR001863Yale Clinical and Translational Science Award52025

1 to 10 of 1,953Source NIH's project files

See all 1,953 nih grants

Papers2,616

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Lysine specific demethylase 5B promises to be a new focus of cancer drug-resistance: combination therapy.Biochim Biophys Acta Rev Cancer202642815836PubTator, text miningPubMed
USP4-Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC.Adv Sci (Weinh)202642811544PubTator, text miningPubMed
SETDB1 cooperates with the CRL4B complex to promote colorectal cancer tumorigenesis by disrupting circadian rhythm.Oncogene202642778664PubTator, text miningPubMed
The role of CHAMP1 in chromatin-mediated DNA damage repair.DNA Repair (Amst)202642748571PubTator, text miningPubMed
USP7/SETDB1 promotes non-small cell lung cancer progression by regulating ferroptosis via NRF2/SLC7A11/GPX4 axis.Gen Physiol Biophys202642717784PubTator, text miningPubMed
Beyond hypoxia and ccRCC: the expanding universe of VHL novel targets and next-generation therapeutics.Biomark Res202642717364PubTator, text miningPubMed
CTCF primes repressive chromatin for rapid BRCA1/BARD1 recruitment to drive homologous recombination repair of DNA double-strand breaks.Nucleic Acids Res202642475683PubTator, text miningPubMed
Setdb1 safeguards proper differentiation of adult intestinal stem cells by controlling chromatin accessibility and transcriptome variability.iScience202642472120PubTator, text miningPubMed
TRAF4 promotes nasopharyngeal carcinoma progression by stabilizing SETDB1 to suppress mitochondrial apoptosis.Mol Cell Biochem202642461470PubTator, text miningPubMed
Setdb1 represses antitumor immunity and tertiary lymphoid structures in hepatocellular carcinoma.J Hepatol202642457040PubTator, text miningPubMed

1 to 10 of 2,616

See all 2,616 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9869

GET https://conductscience.org/api/genes/v1/9869/patents?page=2