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Gene · 987

LRBA: LPS responsive beige-like anchor protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LRBA: LPS responsive beige-like anchor protein. Genes, record 987. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/987

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Gene

Symbol
LRBA
HGNC
Name
LPS responsive beige-like anchor protein
HGNC
NCBI Gene ID
987
NCBI Gene
HGNC ID
HGNC:1742
HGNC
Ensembl
ENSG00000198589
NCBI Gene
Aliases
BGL, CDC4L, CVID8, LAB300, LBA, uc.147
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P50851Lipopolysaccharide-responsive and beige-like anchor protein2,8631Ensembl, GeneID, HGNC

Source UniProt

Patents17

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4640849 A22025-10-291100P50851Espacenet
EP 4641201 A22025-10-297339P50851Espacenet
JP 2025529142 A2025-09-042416P50851Espacenet
US 12371689 B22025-07-292416P50851Espacenet
JP 2025519096 A2025-06-241100P50851Espacenet
JP 2025517969 A2025-06-127339P50851Espacenet
JP 2023510565 A2023-03-14184P50851Espacenet
JP 2022141755 A2022-09-29404P50851Espacenet
US 11446398 B22022-09-2047266P50851Espacenet
JP 2022524081 A2022-04-27150237P50851Espacenet

1 to 10 of 17

See all 17 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants606

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLRBA papersNewest fiscal year
P30DK034854Integrated Epithelial and Muscosal Biology82025
RC2DK118640COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepository72025
ZIABC011436Viral Replication and Interactions with Host Factors72025
ZIAAI000646Transgenic Animal Models Of Human Immune Defects52025
ZIAAI000732Clinical, Immunological and Genetic Analyses of ALPS and Related Immunedysregulatory Disorders52025
ZIAAI001059Defining New Human Immunodeficiency and Immunodysregulation Disorders52025
ZIABC010814Elucidating the Regulation of HIV RNA Functions:Translation and Genome Packaging52025
P30CA008748Cancer Center Support Grant42025
R01AI065617Genetic and Epigenetic Programming of Allergic Airway Inflammation42025
ZIAAI000647Genes And Gene Products As Immunoadjuvants42025

1 to 10 of 606Source NIH's project files

See all 606 nih grants

Papers1,214

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Inborn Errors of Immunity Genotype: A Retrospective Study from the United Arab Emirates.J Clin Immunol202642771195PubTator, text miningPubMed
ABACHAI phase 2 clinical trial: Safety and efficacy of subcutaneous abatacept in patients with CTLA-4 insufficiency or LRBA deficiency.J Allergy Clin Immunol202642763023PubTator, text miningPubMed
Identifying and characterising a plant GH1 β-glucosidase that exhibits hydrolytic activity on N-linked glucopyranoside.FEBS Open Bio202642563430PubTator, text miningPubMed
Characterizing the membrane recruitment domain of BDCPs and its role in gray platelet syndrome.J Cell Biol202642560489PubTator, text miningPubMed
Clinical Spectrum and Therapeutic Options in Monogenic CTLA-4-, LRBA-, or SOCS1-Related Primary Immune Regulatory Disorders.J Allergy Clin Immunol Pract202642409455PubTator, text miningPubMed
Adult-Onset LRBA Deficiency Presenting with Rheumatoid Arthritis-Like Manifestations: A Case Report.J Clin Immunol202642406167PubTator, text miningPubMed
[Clinicopathological features of pediatric monogenic inflammatory bowel disease associated with both IL-10 and non-IL-10 pathways: a differential analysis].Zhonghua Bing Li Xue Za Zhi202642379848PubTator, text miningPubMed
LRBA regulates actin cytoskeleton dynamics through NMIIA during B cell immune responses.EMBO Rep202642286213PubTator, text miningPubMed
Case Report: Different faces of LRBA deficiency in five Moroccan families.Front Immunol202642148132PubTator, text miningPubMed
The Intertwining Between Arthritis and Inborn Errors of Immunity.J Clin Med202642123030PubTator, text miningPubMed

1 to 10 of 1,214

See all 1,214 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/987

GET https://conductscience.org/api/genes/v1/987/patents