Gene · 9882
TBC1D4: TBC1 domain family member 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TBC1D4: TBC1 domain family member 4. Genes, record 9882. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9882
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O60343 | TBC1 domain family member 4 | 1,298 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents19
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 66574 | O60343 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 10209 | O60343 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 10209 | O60343 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 36936 | O60343 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 36936 | O60343 | Espacenet |
| US 11826403 B2 | 2023-11-28 | 2 | O60343 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 36936 | O60343 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 87183 | O60343 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 190154 | O60343 | Espacenet |
| US 10821159 B2 | 2020-11-03 | 2 | O60343 | Espacenet |
1 to 10 of 19
See all 19 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants898
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TBC1D4 papers | Newest fiscal year |
|---|---|---|---|
| P30DK036836 | Diabetes Research Center | 16 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 14 | 2025 |
| P30DK020541 | NYR-Diabetes Research Center (NYR-DRC) | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| P30CA023108 | Cancer Center Support Grant | 5 | 2025 |
| P30DK045735 | Yale Diabetes Research Center | 5 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 5 | 2025 |
| P30DK048520 | Colorado Nutrition Obesity Research Center | 4 | 2025 |
| P30DK079626 | UAB Diabetes Research Center | 4 | 2025 |
| R01DK062370 | Identifying Genes for Type 2 Diabetes: FUSION | 4 | 2025 |
1 to 10 of 898Source NIH's project files
See all 898 nih grantsPapers1,420
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Breast cancer-associated fibroblast-derived exosomal miR-1290 promotes triple-negative breast cancer cell proliferation. | Signal Transduct Target Ther | 2026 | 42786148 | PubTator, text mining | PubMed |
| AS160 At the Crossroads of Nutrient Handling and Mitochondrial Quality Control in Pancreatic β-Cells. | Acta Physiol (Oxf) | 2026 | 42764226 | PubTator, text mining | PubMed |
| WNK1 Phosphorylation Sites in TBC1D1 and TBC1D4 Modulate Cell-Surface Abundance of GLUT1. | Cells | 2026 | 42738876 | PubTator, text mining | PubMed |
| Nx3 Is a Z-Disk Structural and Signaling Hub That Is Reduced in Heart Failure. | Circ Res | 2026 | 42717863 | PubTator, text mining | PubMed |
| TBC1D4-Related Monogenic Diabetes: Molecular Mechanisms, Clinical Recognition, and Therapeutic Implications. | J Diabetes | 2026 | 42629605 | PubTator, text mining | PubMed |
Retraction notice to "Expression characteristics of TBC1D4 activating protein molecule and identification of key module genes for preventing thyroid cancer progression" [Int. J. Biol. Macromol. 278 (2024) 134986]. | Int J Biol Macromol | 2026 | 42527168 | PubTator, text mining | PubMed |
| Proteotoxic Stress Triggers Autophagy-Mediated AS160 Degradation and Metabolic Reprogramming in Colorectal Cancer. | ACS Omega | 2026 | 42110819 | PubTator, text mining | PubMed |
| Canonical and Alternative Pathways (Insulin and Exercise) of GLUT4 Synthesis, Signaling, Intracellular Clustering, and Recruitment to the Plasma Membrane. | Int J Mol Sci | 2026 | 42074118 | PubTator, text mining | PubMed |
| Japanese encephalitis virus orchestrates GLUT4-mediated glucose metabolism to potentiate viral replication via insulin receptor signaling. | PLoS Pathog | 2026 | 41996449 | PubTator, text mining | PubMed |
| Dietary effect on glucose homeostasis is modulated by a loss-of-function variant in the sucrase-isomaltase gene: a randomised, dietary crossover intervention in Inuit. | Diabetologia | 2026 | 41995844 | PubTator, text mining | PubMed |
1 to 10 of 1,420
See all 1,420 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9882
GET https://conductscience.org/api/genes/v1/9882/patents