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Gene · 9882

TBC1D4: TBC1 domain family member 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TBC1D4: TBC1 domain family member 4. Genes, record 9882. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9882

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Gene

Symbol
TBC1D4
HGNC
Name
TBC1 domain family member 4
HGNC
NCBI Gene ID
9882
NCBI Gene
HGNC ID
HGNC:19165
HGNC
Ensembl
ENSG00000136111
NCBI Gene
Aliases
AS160, DKFZp779C0666, KIAA0603, NIDDM5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O60343TBC1 domain family member 41,2982Ensembl, GeneID, HGNC

Source UniProt

Patents19

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1466574O60343Espacenet
EP 4641201 A22025-10-2910209O60343Espacenet
JP 2025517969 A2025-06-1210209O60343Espacenet
JP 2025032204 A2025-03-1136936O60343Espacenet
EP 4461818 A22024-11-1336936O60343Espacenet
US 11826403 B22023-11-282O60343Espacenet
JP 2023058610 A2023-04-2536936O60343Espacenet
US 11446398 B22022-09-2087183O60343Espacenet
JP 2022524081 A2022-04-27190154O60343Espacenet
US 10821159 B22020-11-032O60343Espacenet

1 to 10 of 19

See all 19 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants898

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTBC1D4 papersNewest fiscal year
P30DK036836Diabetes Research Center162025
P30DK020572Michigan Diabetes Research Center (MDRC)142025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)62025
P30CA016672Cancer Center Support Grant52025
P30CA023108Cancer Center Support Grant52025
P30DK045735Yale Diabetes Research Center52025
P30DK063491Diabetes Research Center (DRC)52025
P30DK048520Colorado Nutrition Obesity Research Center42025
P30DK079626UAB Diabetes Research Center42025
R01DK062370Identifying Genes for Type 2 Diabetes: FUSION42025

1 to 10 of 898Source NIH's project files

See all 898 nih grants

Papers1,420

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Breast cancer-associated fibroblast-derived exosomal miR-1290 promotes triple-negative breast cancer cell proliferation.Signal Transduct Target Ther202642786148PubTator, text miningPubMed
AS160 At the Crossroads of Nutrient Handling and Mitochondrial Quality Control in Pancreatic β-Cells.Acta Physiol (Oxf)202642764226PubTator, text miningPubMed
WNK1 Phosphorylation Sites in TBC1D1 and TBC1D4 Modulate Cell-Surface Abundance of GLUT1.Cells202642738876PubTator, text miningPubMed
Nx3 Is a Z-Disk Structural and Signaling Hub That Is Reduced in Heart Failure.Circ Res202642717863PubTator, text miningPubMed
TBC1D4-Related Monogenic Diabetes: Molecular Mechanisms, Clinical Recognition, and Therapeutic Implications.J Diabetes202642629605PubTator, text miningPubMed
Retraction notice to "Expression characteristics of TBC1D4 activating protein molecule and identification of key module genes for preventing thyroid cancer progression" [Int. J. Biol. Macromol. 278 (2024) 134986].
Int J Biol Macromol202642527168PubTator, text miningPubMed
Proteotoxic Stress Triggers Autophagy-Mediated AS160 Degradation and Metabolic Reprogramming in Colorectal Cancer.ACS Omega202642110819PubTator, text miningPubMed
Canonical and Alternative Pathways (Insulin and Exercise) of GLUT4 Synthesis, Signaling, Intracellular Clustering, and Recruitment to the Plasma Membrane.Int J Mol Sci202642074118PubTator, text miningPubMed
Japanese encephalitis virus orchestrates GLUT4-mediated glucose metabolism to potentiate viral replication via insulin receptor signaling.PLoS Pathog202641996449PubTator, text miningPubMed
Dietary effect on glucose homeostasis is modulated by a loss-of-function variant in the sucrase-isomaltase gene: a randomised, dietary crossover intervention in Inuit.Diabetologia202641995844PubTator, text miningPubMed

1 to 10 of 1,420

See all 1,420 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9882

GET https://conductscience.org/api/genes/v1/9882/patents