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Gene · 9966

TNFSF15: TNF superfamily member 15

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TNFSF15: TNF superfamily member 15. Genes, record 9966. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9966

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Gene

Symbol
TNFSF15
HGNC
Name
TNF superfamily member 15
HGNC
NCBI Gene ID
9966
NCBI Gene
HGNC ID
HGNC:11931
HGNC
Ensembl
ENSG00000181634
NCBI Gene
Aliases
MGC129934, MGC129935, TL1, TL1A, TNLG1B, VEGI, VEGI192A
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95150Tumor necrosis factor ligand superfamily member 152517Ensembl, GeneID, HGNC

Source UniProt

Patents255

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4820526 A12026-10-142O95150Espacenet
EP 4719473 A12026-04-082050O95150Espacenet
WO 2026019692 A22026-01-2215O95150Espacenet
JP 2026004568 A2026-01-1468640O95150Espacenet
JP 2026500100 A2026-01-062050O95150Espacenet
US 12509523 B12025-12-302493O95150Espacenet
WO 2025245508 A12025-11-2781O95150Espacenet
US 12466890 B12025-11-112493O95150Espacenet
JP 2025147176 A2025-10-0613613O95150Espacenet
JP 2025147176 A2025-10-0616538O95150Espacenet

1 to 10 of 255

See all 255 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,245

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTNFSF15 papersNewest fiscal year
P30DK063491Diabetes Research Center (DRC)152025
U01DK062413Determining genomic and host-environment contributions to IBD phenotypes152025
U01DK062422Mount Sinai NYC Genetics Research Center: Multi-omic integration across data-types, cell niches and populations142025
U01DK062431IBD Gene Mapping by Clinical and Population Subset122025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital102025
U19AI070535Airway Inflammation and Airway Remodeling in Severe Asthma102025
U01DK062423Genomic and Immunologic Characterization of Inflammatory Bowel Disease and its Phenotypes92025
U01DK062432Montreal-Boston Collaborative GRC92025
R01EY024484Immune Mechanisms in Ocular Graft versus Host Disease82025
P30DK034989Yale Liver Center72025

1 to 10 of 1,245Source NIH's project files

See all 1,245 nih grants

Papers2,280

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Review Article: Beyond the Therapeutic Ceiling in Inflammatory Bowel Disease-Mechanism-Based Positioning and Emerging Therapeutic Strategies.Aliment Pharmacol Ther202642827330PubTator, text miningPubMed
Network of interactions between the tumor necrosis factor superfamily members and small S100 proteins.PLoS One202642809589PubTator, text miningPubMed
Preclinical and clinical evaluation of systemic danegaptide for the treatment of nonproliferative diabetic retinopathy.Sci Transl Med202642777083PubTator, text miningPubMed
Tumor necrosis factor-like cytokine 1 A antagonists for inflammatory bowel disease: A systematic review and meta-analysis.Indian J Gastroenterol202642766208PubTator, text miningPubMed
Targeted Therapies in Inflammatory Bowel Disease: Mechanisms, Comparative Evidence, and Clinical Translation.J Clin Med202642739758PubTator, text miningPubMed
Targeting the TL1A pathway in inflammatory bowel disease: mechanistic insights and emerging therapeutic pipeline.Inflamm Bowel Dis202642660189PubTator, text miningPubMed
TL1A-DR3 Signaling in Inflammatory Bowel Disease: From Pathogenesis to Therapeutic Targeting.Kurume Med J202642633936PubTator, text miningPubMed
Circulating levels of TL1A and its decoy receptor DcR3 in systemic sclerosis.Clin Rheumatol202642622765PubTator, text miningPubMed
Pharmacologic management of metabolic and alcohol-associated liver disease.Metab Target Organ Damage202642577825PubTator, text miningPubMed
TL1A(TNFSF15)-ENO1 axis promotes osteoarthritis by disrupting redox homeostasis via the PI3K/AKT pathway.Osteoarthritis Cartilage202642567404PubTator, text miningPubMed

1 to 10 of 2,280

See all 2,280 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9966

GET https://conductscience.org/api/genes/v1/9966/patents?page=2