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Gene · 9968

MED12: mediator complex subunit 12

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MED12: mediator complex subunit 12. Genes, record 9968. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9968

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Gene

Symbol
MED12
HGNC
Name
mediator complex subunit 12
HGNC
NCBI Gene ID
9968
NCBI Gene
HGNC ID
HGNC:11957
HGNC
Ensembl
ENSG00000184634
NCBI Gene
Aliases
ARC240, CAGH45, FGS1, HDKR, HOPA, KIAA0192, Kto, MED12S, OHDOX, OKS, OPA1, TNRC11, TRAP230
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q93074Mediator of RNA polymerase II transcription subunit 122,1773Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1452802Q93074Espacenet
EP 4641201 A22025-10-299672Q93074Espacenet
JP 2025517969 A2025-06-129672Q93074Espacenet
JP 2023182637 A2023-12-2619Q93074Espacenet
JP 2023518396 A2023-05-0114Q93074Espacenet
US 11446398 B22022-09-2049682Q93074Espacenet
JP 2022524081 A2022-04-27152653Q93074Espacenet
JP 2022512673 A2022-02-07259Q93074Espacenet
EP 3864138 A12021-08-1819Q93074Espacenet
US 11078247 B22021-08-036702Q93074Espacenet

1 to 10 of 16

See all 16 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,572

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMED12 papersNewest fiscal year
P30CA008748Cancer Center Support Grant432025
P30CA016672Cancer Center Support Grant212025
P30CA016058Cancer Center Support Grant142025
R01HD087417Molecular basis of MED12 in the pathogenesis of uterine fibroids142025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center112025
U54MD007602Center for Translational Research in Health Disparities112025
P30CA046934University of Colorado Cancer Center Support Grant72025
P50CA097186The Pacific Northwest Prostate Cancer SPORE72025
R01HD106285Pathological reprogramming of the m6A epitranscriptome in uterine fibroids72025
U10CA180821Alliance for Clinical Trials in Oncology Operations Center - GY11 Funded Extension72025

1 to 10 of 1,572Source NIH's project files

See all 1,572 nih grants

Papers2,273

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Clinical trajectories and magnetic resonance imaging-based triage of uterine leiomyoma molecular subtypes: a large-scale retrospective analysis of 720 genotyped tumors.Am J Obstet Gynecol202642692323PubTator, text miningPubMed
Genetic-Epigenetic Interactions in Uterine Leiomyomas: MED12 Mutations as Predictors of Aberrant DNA Methylation.Genes (Basel)202642650070PubTator, text miningPubMed
How Often are druggable mutations detectable in Metastatic Castration Resistant Prostate Cancer?Urol Int202642594033PubTator, text miningPubMed
Human Myometrial Cell Fate under Chronic Oxidative Stress for Leiomyomagenesis.Res Sq202642539031PubTator, text miningPubMed
Emerging biomarkers in breast fibroadenoma: implications for differential diagnosis, malignant transformation, and precision medicine.Mol Biol Rep202642530698PubTator, text miningPubMed
Discovery of a potent dual-target CDK8 and cyclin C PROTAC degrader for the treatment of colorectal cancer.RSC Med Chem202642519713PubTator, text miningPubMed
A Novel Intronic Variant in MED12 Associated with a Predominantly Hepatobiliary Phenotype Suggestive of Hardikar Syndrome: A Case Report and Literature Review.Genes (Basel)202642510827PubTator, text miningPubMed
Vitamin D3 ameliorates R-loop-induced replication stress and chromosomal instability in MED12-mutant uterine fibroids.Sci Rep202642409897PubTator, text miningPubMed
Dysregulated methylation-ubiquitination crosstalk accelerates intervertebral disc degeneration via MED12 destabilization and cGAS/STING activation.J Clin Invest202642378049PubTator, text miningPubMed
Genomic Characteristics of Leiomyosarcoma: An AACR Project GENIE Study.Anticancer Res202642373270PubTator, text miningPubMed

1 to 10 of 2,273

See all 2,273 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9968

GET https://conductscience.org/api/genes/v1/9968/patents