Gene · 9968
MED12: mediator complex subunit 12
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MED12: mediator complex subunit 12. Genes, record 9968. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9968
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q93074 | Mediator of RNA polymerase II transcription subunit 12 | 2,177 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents16
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 52802 | Q93074 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 9672 | Q93074 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 9672 | Q93074 | Espacenet |
| JP 2023182637 A | 2023-12-26 | 19 | Q93074 | Espacenet |
| JP 2023518396 A | 2023-05-01 | 14 | Q93074 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 49682 | Q93074 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 152653 | Q93074 | Espacenet |
| JP 2022512673 A | 2022-02-07 | 259 | Q93074 | Espacenet |
| EP 3864138 A1 | 2021-08-18 | 19 | Q93074 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 6702 | Q93074 | Espacenet |
1 to 10 of 16
See all 16 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,572
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MED12 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 43 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 21 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 14 | 2025 |
| R01HD087417 | Molecular basis of MED12 in the pathogenesis of uterine fibroids | 14 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 11 | 2025 |
| U54MD007602 | Center for Translational Research in Health Disparities | 11 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 7 | 2025 |
| P50CA097186 | The Pacific Northwest Prostate Cancer SPORE | 7 | 2025 |
| R01HD106285 | Pathological reprogramming of the m6A epitranscriptome in uterine fibroids | 7 | 2025 |
| U10CA180821 | Alliance for Clinical Trials in Oncology Operations Center - GY11 Funded Extension | 7 | 2025 |
1 to 10 of 1,572Source NIH's project files
See all 1,572 nih grantsPapers2,273
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Clinical trajectories and magnetic resonance imaging-based triage of uterine leiomyoma molecular subtypes: a large-scale retrospective analysis of 720 genotyped tumors. | Am J Obstet Gynecol | 2026 | 42692323 | PubTator, text mining | PubMed |
| Genetic-Epigenetic Interactions in Uterine Leiomyomas: MED12 Mutations as Predictors of Aberrant DNA Methylation. | Genes (Basel) | 2026 | 42650070 | PubTator, text mining | PubMed |
| How Often are druggable mutations detectable in Metastatic Castration Resistant Prostate Cancer? | Urol Int | 2026 | 42594033 | PubTator, text mining | PubMed |
| Human Myometrial Cell Fate under Chronic Oxidative Stress for Leiomyomagenesis. | Res Sq | 2026 | 42539031 | PubTator, text mining | PubMed |
| Emerging biomarkers in breast fibroadenoma: implications for differential diagnosis, malignant transformation, and precision medicine. | Mol Biol Rep | 2026 | 42530698 | PubTator, text mining | PubMed |
| Discovery of a potent dual-target CDK8 and cyclin C PROTAC degrader for the treatment of colorectal cancer. | RSC Med Chem | 2026 | 42519713 | PubTator, text mining | PubMed |
| A Novel Intronic Variant in MED12 Associated with a Predominantly Hepatobiliary Phenotype Suggestive of Hardikar Syndrome: A Case Report and Literature Review. | Genes (Basel) | 2026 | 42510827 | PubTator, text mining | PubMed |
| Vitamin D3 ameliorates R-loop-induced replication stress and chromosomal instability in MED12-mutant uterine fibroids. | Sci Rep | 2026 | 42409897 | PubTator, text mining | PubMed |
| Dysregulated methylation-ubiquitination crosstalk accelerates intervertebral disc degeneration via MED12 destabilization and cGAS/STING activation. | J Clin Invest | 2026 | 42378049 | PubTator, text mining | PubMed |
| Genomic Characteristics of Leiomyosarcoma: An AACR Project GENIE Study. | Anticancer Res | 2026 | 42373270 | PubTator, text mining | PubMed |
1 to 10 of 2,273
See all 2,273 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9968
GET https://conductscience.org/api/genes/v1/9968/patents