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NR1H4: nuclear receptor subfamily 1 group H member 4

1 protein, 19 patents, 9 drugs, 139 trials, 3,786 NIH grants and 9,488 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNR1H4HGNC
Namenuclear receptor subfamily 1 group H member 4HGNC
NCBI Gene ID9971NCBI Gene
HGNC IDHGNC:7967HGNC
EnsemblENSG00000012504NCBI Gene
AliasesBAR, FXR, HRR-1, HRR1, PFIC5, RIP14NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q96RI1Bile acid receptor48691Ensembl, GeneID, HGNCUniProt

Patents 19

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-2920290Q96RI1Espacenet
JP 2025147176 A2025-10-0615419Q96RI1Espacenet
JP 2025517969 A2025-06-1220290Q96RI1Espacenet
JP 2025028160 A2025-02-2815419Q96RI1Espacenet
KR 1020250010750 A2025-01-2115419Q96RI1Espacenet
JP 2024109657 A2024-08-1415258Q96RI1Espacenet
US 11446398 B22022-09-2058420Q96RI1Espacenet
JP 2022524081 A2022-04-27161391Q96RI1Espacenet
JP 2021536249 A2021-12-2715612Q96RI1Espacenet
JP 2021507703 A2021-02-2515572Q96RI1Espacenet

Drugs 9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CHENODIOLCHEMBL240597Bile acid receptor FXR agonistAGONISTChEMBL
CILOFEXORCHEMBL4297613Bile acid receptor FXR agonistAGONISTChEMBL
NIDUFEXORCHEMBL4297626Bile acid receptor FXR agonistAGONISTChEMBL
OBETICHOLIC ACIDCHEMBL566315Bile acid receptor FXR agonistAGONISTChEMBL
PX-102CHEMBL3822773Bile acid receptor FXR agonistAGONISTChEMBL
TERN-101CHEMBL3746388Bile acid receptor FXR agonistAGONISTChEMBL
TROPIFEXORCHEMBL4298169Bile acid receptor FXR agonistAGONISTChEMBL
TUROFEXORATE ISOPROPYLCHEMBL454138Bile acid receptor FXR agonistAGONISTChEMBL
URSODIOLCHEMBL1551Bile acid receptor FXR agonistAGONISTChEMBL

Trials 139

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07477782URSODIOLPHASE2ClinicalTrials.gov
NCT07296458URSODIOLPHASE3ClinicalTrials.gov
NCT07110987URSODIOLClinicalTrials.gov
NCT07104786OBETICHOLIC ACIDPHASE2ClinicalTrials.gov
NCT07102979URSODIOLClinicalTrials.gov
NCT07068191URSODIOLClinicalTrials.gov
NCT06842472URSODIOLPHASE2ClinicalTrials.gov
NCT06755541URSODIOLPHASE3ClinicalTrials.gov
NCT06715319URSODIOLPHASE3ClinicalTrials.gov
NCT06715319OBETICHOLIC ACIDPHASE3ClinicalTrials.gov

NIH grants 3786

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK034989Yale Liver Center402,025NIH's project files
ZIABC005562Xenobiotic receptors372,025NIH's project files
ZIABC005708Xenobiotic metabolism, cancer chemoprevention and cancer biomarkers342,025NIH's project files
P30DK120515San Diego Digestive Diseases Research Center282,025NIH's project files
P30DK056338Texas Medical Center Digestive Diseases Center212,025NIH's project files
P50AA011999Southern California Research Center for ALPD and Cirrhosis192,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award192,025NIH's project files
P30CA008748Cancer Center Support Grant182,025NIH's project files
T32ES007148Training in Environmental Toxicology182,025NIH's project files
P30DK048520Colorado Nutrition Obesity Research Center172,025NIH's project files

Papers 9488

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825856PubTator, text miningPubMed
42819668PubTator, text miningPubMed
42816648PubTator, text miningPubMed
42813208PubTator, text miningPubMed
42811458PubTator, text miningPubMed
42801336PubTator, text miningPubMed
42795448PubTator, text miningPubMed
42794738PubTator, text miningPubMed
42793148PubTator, text miningPubMed
42773017PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license