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Gene · 9978

RBX1: ring-box 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RBX1: ring-box 1. Genes, record 9978. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9978

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Gene

Symbol
RBX1
HGNC
Name
ring-box 1
HGNC
NCBI Gene ID
9978
NCBI Gene
HGNC ID
HGNC:9928
HGNC
Ensembl
ENSG00000100387
NCBI Gene
Aliases
BA554C12.1, RNF75, ROC1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P62877E3 ubiquitin-protein ligase RBX1108106Ensembl, GeneID, HGNC

Source UniProt

Patents61

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12539325 B22026-02-0359P62877Espacenet
EP 4679090 A12026-01-1417P62877Espacenet
EP 4650780 A22025-11-19320P62877Espacenet
JP 2025517970 A2025-06-12320P62877Espacenet
WO 2024240908 A12024-11-2825P62877Espacenet
US 12133879 B22024-11-0559P62877Espacenet
US 11872193 B22024-01-1659P62877Espacenet
US 11564998 B22023-01-314703P62877Espacenet
US 11446398 B22022-09-2075133P62877Espacenet
JP 2022524081 A2022-04-27178104P62877Espacenet

1 to 10 of 61

See all 61 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
IBERDOMIDECHEMBL3989927CRL4(CRBN) E3 ubiquitin ligase modulatorMODULATORChEMBL
LENALIDOMIDECHEMBL848CRL4(CRBN) E3 ubiquitin ligase inhibitorINHIBITORChEMBL
LENALIDOMIDECHEMBL848CRL4(CRBN) E3 ubiquitin ligase modulatorMODULATORChEMBL
LENALIDOMIDE HYDROCHLORIDE MONOHYDRATECHEMBL6068337CRL4(CRBN) E3 ubiquitin ligase modulatorMODULATORChEMBL
POMALIDOMIDECHEMBL43452CRL4(CRBN) E3 ubiquitin ligase inhibitorINHIBITORChEMBL
THALIDOMIDECHEMBL468CRL4(CRBN) E3 ubiquitin ligase inhibitorINHIBITORChEMBL

Trials1,695

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605416LENALIDOMIDEPHASE2ClinicalTrials.gov
NCT07601100IBERDOMIDEPHASE1/PHASE2ClinicalTrials.gov
NCT07600151LENALIDOMIDEPHASE1/PHASE2ClinicalTrials.gov
NCT07585747LENALIDOMIDEPHASE2ClinicalTrials.gov
NCT07569757POMALIDOMIDEPHASE3ClinicalTrials.gov
NCT07562022LENALIDOMIDEPHASE3ClinicalTrials.gov
NCT07555938POMALIDOMIDEPHASE3ClinicalTrials.gov
NCT07532525POMALIDOMIDEPHASE1ClinicalTrials.gov
NCT07523737POMALIDOMIDEPHASE2ClinicalTrials.gov
NCT07505849LENALIDOMIDEPHASE2ClinicalTrials.gov

1 to 10 of 1,695

See all 1,695 trials

NIH grants2,387

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRBX1 papersNewest fiscal year
P30CA021765Cancer Center Support Grant (CCSG)292025
P30ES006694Southwest Environmental Health Sciences Center242025
P30CA008748Cancer Center Support Grant232025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control222025
P30CA016672Cancer Center Support Grant152025
R01CA214608The molecular basis of IMiD induced neo-substrate recruitment to the CRL4CRBN ubiquitin E3 ligase142025
P30CA016087Cancer Center Support Grant132025
R01HL096376E3 Ligase-Mediated Immunosuppression in Acute Lung Injury132025
R01HL097376Sepsis-Associated Immune Suppression and F-box Proteins132025
P30CA016086Cancer Center Support Grant102025

1 to 10 of 2,387Source NIH's project files

See all 2,387 nih grants

Papers3,762

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
HSP90 shields ROC1/RBX1 from proteasomal degradation by CHIP E3 ubiquitin ligase to promote lung adenocarcinoma.Signal Transduct Target Ther202642764310PubTator, text miningPubMed
DH-AUTAC induces ferroptosis in colorectal cancer by targeting DHODH for autophagic degradation through KCTD10-SQSTM1 signaling.J Gastroenterol202642622824PubTator, text miningPubMed
Recent advances in etiology and treatment of von Hippel-Lindau Disease (VHLD).Cancer Metastasis Rev202642593521PubTator, text miningPubMed
Circadian Regulation of Glucose Metabolism: Implications for Pathogenesis and Chronotherapy of Type 2 Diabetes.Diabetology (Basel)202642583078PubTator, text miningPubMed
Neddylation pathway promotes the ubiquitinated degradation of FBXO21 in lung cancer cells.Carcinogenesis202642555346PubTator, text miningPubMed
Neddylation of NFATc1 and Runx2 regulates osteoclast-osteoblast balance and represents a dual-action therapeutic target for postmenopausal osteoporosis.Exp Mol Med202642543398PubTator, text miningPubMed
African swine fever virus pMGF360-3 L suppresses innate immunity by facilitating CMA-dependent SKP1 degradation to promote BNIP3-mediated mitophagy.Autophagy202642543005PubTator, text miningPubMed
Alphavirus M1 disrupts super-enhancer-driven oncogenic transcription via non-structural protein NSP2 in osteosarcoma.Nat Commun202642386745PubTator, text miningPubMed
TDTAC: a generalized time-dependent torsion angle correlation framework for resolving directional coordination in large biomolecular assemblies.Front Mol Biosci202642311447PubTator, text miningPubMed
Structure of the E3 ligase CRL2ZYG11B with substrates reveals the molecular basis for N-degron recognition and ubiquitination.Cell Rep202642224082PubTator, text miningPubMed

1 to 10 of 3,762

See all 3,762 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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