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Paper · 103003

Rearrangement of genetic information may produce immunoglobulin diversity.

Weigert M and 4 others. Nature, 1978. Cited by 206 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Rearrangement of genetic information may produce immunoglobulin diversity. Papers, record 103003. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/103003

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Rearrangement of genetic information may produce immunoglobulin diversity.
PubMed
Journal
Nature
PubMed
Year
1978
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
206
iCite
Relative citation ratio, by iCite
3.3
iCite
Revised in PubMed
2026-10-12
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Weigert MM
2Gatmaitan LL
3Loh EE
4Schilling JJ
5Hood LL

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antibody SpecificityMajor topic
Binding Sites, AntibodyMajor topic
GenesMajor topic
Immunoglobulin Light ChainsMajor topic
Immunoglobulin Variable RegionMajor topic
Immunoglobulin kappa-ChainsMajor topic
Myeloma ProteinsMajor topic
Amino Acid Sequence
Animals
Base Sequence
Mice
Mice, Inbred BALB C
Mice, Inbred NZB
Mutation

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References33

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
1408,420Analysis of the diversity of murine antibodies to dextran B1355. II. Demonstration of multiple idiotypes with variable expression in several strains.J Immunol1977https://conductscience.org/library/papers/408420PubMed
2408,080Genetic control of antibody variable regions.Cold Spring Harb Symp Quant Biol1977https://conductscience.org/library/papers/408080PubMed
399,815Antibody diversity.Science1978https://conductscience.org/library/papers/99815PubMed
44,213,392Specificity of antibodies: primary structural basis of hapten binding.Science1974https://conductscience.org/library/papers/4213392PubMed
54,168,589Linked groups of residues in immunoglobulin k chains.Nature1967https://conductscience.org/library/papers/4168589PubMed
6408,263A molecular hybridization approach for the determination of the immunoglobulin V-gene pool size.Immunol Rev1977https://conductscience.org/library/papers/408263PubMed
74,524,646The three dimensional structure of a combining region-ligand complex of immunoglobulin NEW at 3.5-A resolution.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4524646PubMed
8408,078Somatic cell genetics of antibody-secreting cells: studies of clonal diversification and analysis by cell fusion.Cold Spring Harb Symp Quant Biol1977https://conductscience.org/library/papers/408078PubMed
94,555,516Immunoglobulin-producing tumors and myeloma proteins of mice.Physiol Rev1972https://conductscience.org/library/papers/4555516PubMed
10824,647Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/824647PubMed

1 to 10 of 33

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Cited by63

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 206 citations.

PMIDTitleJournalYearIn PapersSource
39,708,804Mutability and hypermutation antagonize immunoglobulin codon optimality.Mol Cell2025https://conductscience.org/library/papers/39708804PubMed
38,459,209B-Cell Receptor Repertoire: Recent Advances in Autoimmune Diseases.Clin Rev Allergy Immunol2024https://conductscience.org/library/papers/38459209PubMed
35,350,381Shared Mechanisms for Mutually Exclusive Expression and Antigenic Variation by Protozoan Parasites.Front Cell Dev Biol2022https://conductscience.org/library/papers/35350381PubMed
35,315,770Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities.Elife2022https://conductscience.org/library/papers/35315770PubMed
28,659,912C-Terminal Domain of Hemocyanin, a Major Antimicrobial Protein from Litopenaeus vannamei: Structural Homology with Immunoglobulins and Molecular Diversity.Front Immunol2017https://conductscience.org/library/papers/28659912PubMed
24,406,074Human syndromes of immunodeficiency and dysregulation are characterized by distinct defects in T-cell receptor repertoire development.J Allergy Clin Immunol2014https://conductscience.org/library/papers/24406074PubMed
24,376,267Integrating B cell lineage information into statistical tests for detecting selection in Ig sequences.J Immunol2014https://conductscience.org/library/papers/24376267PubMed
24,265,630Germline Amino Acid Diversity in B Cell Receptors is a Good Predictor of Somatic Selection Pressures.Front Immunol2013https://conductscience.org/library/papers/24265630PubMed
22,566,951Innate immune complexity in the purple sea urchin: diversity of the sp185/333 system.Front Immunol2012https://conductscience.org/library/papers/22566951PubMed
19,665,968Chromatin architecture and the generation of antigen receptor diversity.Cell2009https://conductscience.org/library/papers/19665968PubMed

1 to 10 of 63

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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