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Paper · 1054841

Morphine receptors as regulators of adenylate cyclase activity.

Sharma SK and 2 others. Proc Natl Acad Sci U S A, 1975. Cited by 592 papers, by iCite.

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ConductScience Library. Morphine receptors as regulators of adenylate cyclase activity. Papers, record 1054841. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/1054841

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Morphine receptors as regulators of adenylate cyclase activity.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1975
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
592
iCite
Relative citation ratio, by iCite
18.5
iCite
Revised in PubMed
2024-05-27
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Sharma SKS K
2Nirenberg MM
3Klee WAW A

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Adenylyl Cyclase InhibitorsMajor topic
MorphineMajor topic
Receptors, DrugMajor topic
Animals
Cell Line
Glioma
Hybrid Cells
Mice
Naloxone
Neuroblastoma
Prostaglandins
Rats

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References22

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,857,160High activity of choline acetyltransferase induced in neuroblastoma x glia hybrid cells.Exp Cell Res1974https://conductscience.org/library/papers/4857160PubMed
24,111,970Genetic dissection of neural properties using somatic cell hybrids.Nat New Biol1972https://conductscience.org/library/papers/4111970PubMed
34,371,639Hypothesis: Inhibition of E prostaglandin-sensitive adenyl cyclase as the mechanism of morphine analgesia.Prostaglandins1974https://conductscience.org/library/papers/4371639PubMed
44,361,995Morphine-like drugs inhibit the stimulation of E prostaglandins of cyclic AMP formation by rat brain homogenate.Nature1974https://conductscience.org/library/papers/4361995PubMed
54,366,392Stimulation by thyrotropin of horse thyroid plasma membranes adenylate cyclase: evidence of cooperativity.Biochem Biophys Res Commun1974https://conductscience.org/library/papers/4366392PubMed
64,607,3685'-Guanylylimidodiphosphate, a potent activator of adenylate cyclase systems in eukaryotic cells.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4607368PubMed
74,358,641Evidence for interdependent action of glucagon and nucleotides on the hepatic adenylate cyclase system.J Biol Chem1974https://conductscience.org/library/papers/4358641PubMed
84,364,028Adenylate cyclase. A new kinetic analysis of the effects of hormones and fluoride ion.J Biol Chem1974https://conductscience.org/library/papers/4364028PubMed
94,208,548Kinetic evidence for the presence of two prostaglandin receptor sites regulating the activity of intestinal adenylate cyclase sensitive to Escherichia coli enterotoxin.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4208548PubMed
104,827,395A highly sensitive adenylate cyclase assay.Anal Biochem1974https://conductscience.org/library/papers/4827395PubMed

1 to 10 of 22

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Cited by108

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 592 citations.

PMIDTitleJournalYearIn PapersSource
42,688,369Morphine-induced μ-opioid receptor isoform MOR-1X amplifies dependence-related signaling.Front Neurosci2026https://conductscience.org/library/papers/42688369PubMed
40,630,856Molecular and cellular basis of mu-opioid receptor signaling: mechanisms underlying tolerance and dependence development.Front Neurosci2025https://conductscience.org/library/papers/40630856PubMed
37,027,339Mu opioid receptor-mediated release of endolysosome iron increases levels of mitochondrial iron, reactive oxygen species, and cell death.NeuroImmune Pharm Ther2023https://conductscience.org/library/papers/37027339PubMed
33,704,603Synthesis of the Mechanisms of Opioid Tolerance: Do We Still Say NO?Cell Mol Neurobiol2021https://conductscience.org/library/papers/33704603PubMed
30,788,113Pathophysiology and management of opioid-induced constipation: European expert consensus statement.United European Gastroenterol J2019https://conductscience.org/library/papers/30788113PubMed
30,259,415The Cholinergic System as a Treatment Target for Opioid Use Disorder.CNS Drugs2018https://conductscience.org/library/papers/30259415PubMed
28,255,005International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases.Pharmacol Rev2017https://conductscience.org/library/papers/28255005PubMed
28,034,973Opioid-Induced Constipation and Bowel Dysfunction: A Clinical Guideline.Pain Med2017https://conductscience.org/library/papers/28034973PubMed
27,234,425Calcium activated adenylyl cyclase AC8 but not AC1 is required for prolonged behavioral anxiety.Mol Brain2016https://conductscience.org/library/papers/27234425PubMed
26,557,892Evolving paradigms in the treatment of opioid-induced bowel dysfunction.Ther Adv Gastroenterol2015https://conductscience.org/library/papers/26557892PubMed

1 to 10 of 108

See all 108 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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