Paper · 10691732

ATR disruption leads to chromosomal fragmentation and early embryonic lethality.

Brown EJ and 1 other. Genes Dev, 2000. Cited by 762 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Papers, record 10691732. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/10691732

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: ATR disruption leads to chromosomal fragmentation and early embryonic lethality.; PubMed
Journal: Genes Dev; PubMed
Year: 2000; PubMed
Publication types: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/10691732/; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC316378/; PubMed
The journal: https://conductscience.org/library/journal-index/8711660; PubMed
Citations, by iCite: 762; iCite
Relative citation ratio, by iCite: 11.7; iCite
Revised in PubMed: 2021-12-03; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Brown EJ	E J
2	Baltimore D	D

Source PubMed

Topics23

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Cell Cycle Proteins	Major topic
Chromosome Aberrations	Major topic
Fetal Death	Major topic
Gene Expression Regulation, Developmental	Major topic
Protein Serine-Threonine Kinases	Major topic
Animals
Apoptosis
Ataxia Telangiectasia Mutated Proteins
BRCA1 Protein
BRCA2 Protein
Blastocyst
Caspases
Cell Transformation, Neoplastic
DNA Repair
Gene Targeting
Genotype
Mice
Mice, Inbred C57BL
Mice, Knockout
Mitosis
Neoplasm Proteins
Neoplasms, Experimental
Transcription Factors

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References36

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	9,925,639	A role for ATR in the DNA damage-induced phosphorylation of p53.	Genes Dev	1999	https://conductscience.org/library/papers/9925639	PubMed
2	10,524,633	14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage.	Nature	1999	https://conductscience.org/library/papers/10524633	PubMed
3	10,198,641	Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells.	Mol Cell	1999	https://conductscience.org/library/papers/10198641	PubMed
4	10,550,055	Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.	Science	1999	https://conductscience.org/library/papers/10550055	PubMed
5	2,422,760	Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells.	Science	1986	https://conductscience.org/library/papers/2422760	PubMed
6	8,348,613	Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase.	Cell	1993	https://conductscience.org/library/papers/8348613	PubMed
7	8,008,069	A mammalian protein targeted by G1-arresting rapamycin-receptor complex.	Nature	1994	https://conductscience.org/library/papers/8008069	PubMed
8	7,922,305	Tumor spectrum analysis in p53-mutant mice.	Curr Biol	1994	https://conductscience.org/library/papers/7922305	PubMed
9	7,923,116	The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia.	Cancer Res	1994	https://conductscience.org/library/papers/7923116	PubMed
10	7,926,756	Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.	Genes Dev	1994	https://conductscience.org/library/papers/7926756	PubMed

1 to 10 of 36

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Cited by482

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 762 citations.

PMID	Title	Journal	Year	In Papers	Source
42,778,539	Synthetic lethality in cancer: mechanisms, therapeutic exploitation and clinical translation.	Signal Transduct Target Ther	2026	https://conductscience.org/library/papers/42778539	PubMed
42,493,622	Structural mechanism of TOPBP1 activating the ATR-ATRIP replication checkpoint kinase.	Nat Struct Mol Biol	2026	https://conductscience.org/library/papers/42493622	PubMed
42,423,258	ATZ-1 promotes DNA replication efficiency to maintain normal meiotic function.	FEBS Open Bio	2026	https://conductscience.org/library/papers/42423258	PubMed
42,401,703	PARG inhibition reduces ssDNA levels and limits RPA loading upon replication fork collapse.	EMBO Rep	2026	https://conductscience.org/library/papers/42401703	PubMed
41,986,659	ATR inhibition potentiates the antitumor efficacy of HER3-DXd in HER3-positive/HR-positive breast cancer by increasing DNA damage.	Br J Cancer	2026	https://conductscience.org/library/papers/41986659	PubMed
41,973,002	ATR and PKMYT1 Inhibition Resensitizes a Subset of TNBC Patient-Derived Models to Carboplatin, Inducing Mitotic Catastrophe.	Cancer Res Commun	2026	https://conductscience.org/library/papers/41973002	PubMed
41,946,360	The DNA damage response pathway is required for multiciliated cell differentiation.	Curr Biol	2026	https://conductscience.org/library/papers/41946360	PubMed
41,899,393	Roles of DNA Damage Response Pathway in the Regulation of the Nuclear Envelope.	Curr Issues Mol Biol	2026	https://conductscience.org/library/papers/41899393	PubMed
41,865,289	An updated view on lagging strand DNA replication: implications for the replication stress response.	Cell Cycle	2026	https://conductscience.org/library/papers/41865289	PubMed
41,643,682	Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability.	Mol Cell	2026	https://conductscience.org/library/papers/41643682	PubMed

1 to 10 of 482

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
ATR	545	PubTator's text mining	https://conductscience.org/library/genes/545

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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