Paper · 1069290

Simultaneous synthesis of types I and III collagen by fibroblasts in culture.

Gay S and 4 others. Proc Natl Acad Sci U S A, 1976. Cited by 240 papers, by iCite.

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ConductScience Library. Simultaneous synthesis of types I and III collagen by fibroblasts in culture. Papers, record 1069290. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/1069290

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Simultaneous synthesis of types I and III collagen by fibroblasts in culture.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 1976; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/1069290/; PubMed
DOI: https://doi.org/10.1073/pnas.73.11.4037; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC431318/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 240; iCite
Relative citation ratio, by iCite: 8.36; iCite
Revised in PubMed: 2019-05-01; PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Gay S	S
2	Martin GR	G R
3	Muller PK	P K
4	Timpl R	R
5	Kuhn K	K

Source PubMed

Topics8

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Collagen	Major topic
Fibroblasts	Major topic
Procollagen	Major topic
Ascorbic Acid
Cell Line
Ehlers-Danlos Syndrome
Humans
Skin

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References23

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	68,919	Production and specificity of antibodies against the aminoterminal region in type III collagen.	Immunology	1976	https://conductscience.org/library/papers/68919	PubMed
2	1,086,233	H-2-linked genetic control of antibody response to soluble calf skin collagen in mice.	Eur J Immunol	1975	https://conductscience.org/library/papers/1086233	PubMed
3	4,508,318	Production of procollagen by human fibroblasts in culture.	Proc Natl Acad Sci U S A	1972	https://conductscience.org/library/papers/4508318	PubMed
4	4,599,009	Biosynthesis of collagen. The biochemist's view.	Fed Proc	1974	https://conductscience.org/library/papers/4599009	PubMed
5	4,342,111	The effect of ascorbic acid on collagen polypeptide synthesis and proline hydroxylation during the growth of cultured fibroblasts.	Arch Biochem Biophys	1972	https://conductscience.org/library/papers/4342111	PubMed
6	4,353,422	Identification of two distinct species of procollagen synthesized by a clonal line of calf dermatosparactic cells.	Nat New Biol	1973	https://conductscience.org/library/papers/4353422	PubMed
7	4,120,825	Immunochemical properties of procollagen from dermatosparactic calves.	Eur J Biochem	1973	https://conductscience.org/library/papers/4120825	PubMed
8	4,598,122	(Alpha1(3))3 human skin collagen. Release by pepsin digestion and preponderance in fetal life.	J Biol Chem	1974	https://conductscience.org/library/papers/4598122	PubMed
9	4,509,328	Precursors of collagen secreted by cultured human fibroblasts.	Proc Natl Acad Sci U S A	1972	https://conductscience.org/library/papers/4509328	PubMed
10	4,742,738	Defect in conversion of procollagen to collagen in a form of Ehlers-Danlos syndrome.	Science	1973	https://conductscience.org/library/papers/4742738	PubMed

1 to 10 of 23

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Cited by54

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 240 citations.

PMID	Title	Journal	Year	In Papers	Source
34,807,415	Tendon Extracellular Matrix Assembly, Maintenance and Dysregulation Throughout Life.	Adv Exp Med Biol	2021	https://conductscience.org/library/papers/34807415	PubMed
30,841,909	Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology.	J Exp Clin Cancer Res	2019	https://conductscience.org/library/papers/30841909	PubMed
30,103,800	Establishment of a complex skin structure via layered co-culture of keratinocytes and fibroblasts derived from induced pluripotent stem cells.	Stem Cell Res Ther	2018	https://conductscience.org/library/papers/30103800	PubMed
24,709,778	Endothelial cells enhance the in vivo bone-forming ability of osteogenic cell sheets.	Lab Invest	2014	https://conductscience.org/library/papers/24709778	PubMed
23,954,412	Collagen V localizes to pericellular sites during tendon collagen fibrillogenesis.	Matrix Biol	2014	https://conductscience.org/library/papers/23954412	PubMed
22,358,545	Isolation, culture and characterization of a primary fibroblast cell line from channel catfish.	Cytotechnology	1998	https://conductscience.org/library/papers/22358545	PubMed
21,108,049	Outgrowth of fibroblast cells from goat skin explants in three different culture media and the establishment of cell lines.	In Vitro Cell Dev Biol Anim	2011	https://conductscience.org/library/papers/21108049	PubMed
16,068,188	High cell density alters the ratio of type III to I collagen synthesis by fibroblasts.	Nature	1979	https://conductscience.org/library/papers/16068188	PubMed
7,621,517	Expression of fibronectin, laminin and ribosomes in normal and nocodazole-treated neonatal heart cells in culture: a study by laser scanning confocal microscopy and immunocytochemistry.	Cell Tissue Res	1995	https://conductscience.org/library/papers/7621517	PubMed
7,591,977	Collagen fibril diameter distribution in patellar tendon autografts after posterior cruciate ligament reconstruction in sheep: changes over time.	J Anat	1995	https://conductscience.org/library/papers/7591977	PubMed

1 to 10 of 54

See all 54 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
COL3A1	1,281	PubTator's text mining	https://conductscience.org/library/genes/1281

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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