Paper · 10693759

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb.

Wang B and 2 others. Cell, 2000. Cited by 849 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Papers, record 10693759. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/10693759

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb.; PubMed
Journal: Cell; PubMed
Year: 2000; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/10693759/; PubMed
DOI: https://doi.org/10.1016/s0092-8674(00)80678-9; PubMed
The journal: https://conductscience.org/library/journal-index/0413066; PubMed
Citations, by iCite: 849; iCite
Relative citation ratio, by iCite: 14; iCite
Revised in PubMed: 2022-03-09; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Wang B	B
2	Fallon JF	J F
3	Beachy PA	P A

Source PubMed

Topics28

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
DNA-Binding Proteins	Major topic
Limb Buds	Major topic
Nerve Tissue Proteins	Major topic
Protein Processing, Post-Translational	Major topic
Proteins	Major topic
Repressor Proteins	Major topic
Trans-Activators	Major topic
Transcription Factors	Major topic
Xenopus Proteins	Major topic
Animals
Antibodies
Base Sequence
Body Patterning
COS Cells
Chick Embryo
Cyclic AMP-Dependent Protein Kinases
DNA, Complementary
Gene Expression Regulation, Developmental
Hedgehog Proteins
Humans
Kruppel-Like Transcription Factors
Mice
Molecular Sequence Data
Nuclear Proteins
Phosphorylation
Transcription, Genetic
Zinc Finger Protein Gli2
Zinc Finger Protein Gli3

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
HD32551	NICHD NIH HHS	United States	R01HD032551	PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by468

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 849 citations.

PMID	Title	Journal	Year	In Papers	Source
42,856,887	Case Report: Pallister-Hall syndrome diagnosed in adulthood during evaluation of recurrent hypoglycemia.	Front Endocrinol (Lausanne)	2026	https://conductscience.org/library/papers/42856887	PubMed
42,405,753	Mechanistic insights into transcriptional regulation of ARHGAP36 expression identify a factor predictive of neuroblastoma survival.	Elife	2026	https://conductscience.org/library/papers/42405753	PubMed
42,396,316	Rare protein-coding variation and the genetic architecture of height in >1.4 million individuals.	medRxiv	2026	https://conductscience.org/library/papers/42396316	PubMed
42,268,917	Smoothened and ciliary GPCRs regulate ciliary protein kinase A activity involved in Hedgehog signal transduction.	PLoS Biol	2026	https://conductscience.org/library/papers/42268917	PubMed
42,231,312	Primary cilia and neural computation.	J Biomed Sci	2026	https://conductscience.org/library/papers/42231312	PubMed
42,204,175	Evolution of limb and digit identity genes since the tetrapod ancestor.	Nat Commun	2026	https://conductscience.org/library/papers/42204175	PubMed
42,000,925	Sirt1 sustains Sonic hedgehog signaling to promote medulloblastoma progression through regulating Gli3 processing.	Oncogene	2026	https://conductscience.org/library/papers/42000925	PubMed
41,546,624	Gli3R-mediated inhibition of hedgehog signaling alters the embryonic transcriptome in zebrafish.	G3 (Bethesda)	2026	https://conductscience.org/library/papers/41546624	PubMed
41,058,551	GliFHV mice: a tool to investigate GLI processing and localization.	Development	2025	https://conductscience.org/library/papers/41058551	PubMed
41,000,862	Gli3R-mediated inhibition of hedgehog signaling alters the embryonic transcriptome in zebrafish.	bioRxiv	2025	https://conductscience.org/library/papers/41000862	PubMed

1 to 10 of 468

See all 468 cited by

Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
GLI3	2,737	Swiss-Prot's references	https://conductscience.org/library/genes/2737	NCBI Gene
GLI1	2,735	PubTator's text mining	https://conductscience.org/library/genes/2735	NCBI Gene
GLI2	2,736	PubTator's text mining	https://conductscience.org/library/genes/2736	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data1

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bank	Accession
GENBANK	AF222990

Source GENBANK

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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