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Paper · 11070098

Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.

Esteller M and 7 others. N Engl J Med, 2000. Cited by 1,817 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. Papers, record 11070098. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/11070098

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.
PubMed
Journal
N Engl J Med
PubMed
Year
2000
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
1,817
iCite
Relative citation ratio, by iCite
35.1
iCite
Revised in PubMed
2022-04-09
PubMed

Authors8

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Esteller MM
2Garcia-Foncillas JJ
3Andion EE
4Goodman SNS N
5Hidalgo OFO F
6Vanaclocha VV
7Baylin SBS B
8Herman JGJ G

Source PubMed

Topics21

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antineoplastic Agents, AlkylatingMajor topic
Brain NeoplasmsMajor topic
CarmustineMajor topic
DNA MethylationMajor topic
DNA RepairMajor topic
GliomaMajor topic
O(6)-Methylguanine-DNA MethyltransferaseMajor topic
Analysis of Variance
DNA Adducts
DNA, Neoplasm
Disease-Free Survival
Drug Resistance
Female
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Humans
Male
Middle Aged
Prognosis
Promoter Regions, Genetic
Survival Analysis

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials2

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's recordSource
NCT00560118Fotemustine in Treating Patients With Metastatic MelanomaBackgroundClinicalTrials.gov
NCT01574092Irinotecan in Combination With Cisplatin in Pediatric Patients With Unfavorable Prognosis GliomasBackgroundClinicalTrials.gov

Comments and corrections4

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn PapersSource
Comment in11,070,107Pharmacogenomics--teaching old drugs new tricks.https://conductscience.org/library/papers/11070107PubMed
Comment in11,229,337The DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.https://conductscience.org/library/papers/11229337PubMed
Comment in11,229,338The DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.https://conductscience.org/library/papers/11229338PubMed
Comment in11,229,339The DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.https://conductscience.org/library/papers/11229339PubMed

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by952

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1,817 citations.

PMIDTitleJournalYearIn PapersSource
42,989,284IFN-γ signaling drives multiple immunosuppressive pathways and poor clinical outcome in glioblastoma.BMC Med2026https://conductscience.org/library/papers/42989284PubMed
42,958,602Glioblastoma as a dynamic tumor ecosystem: from molecular alterations to therapeutic translation.Exp Hematol Oncol2026https://conductscience.org/library/papers/42958602PubMed
42,947,166
Contrasting molecular and pharmacodynamic signatures of response and resistance to sequential bortezomib and temozolomide in recurrent IDH-wildtype glioblastoma and grade 4 IDH-mutant astrocytoma: an exploratory interim analysis of NCT03643549 phase IB/II trial.
Biomark Res2026https://conductscience.org/library/papers/42947166PubMed
42,818,960N 6-methyladenosine promotes temozolomide resistance through mRNA stabilization in glioblastoma cells.NAR Cancer2026https://conductscience.org/library/papers/42818960PubMed
42,196,180SDK1 as an Independent Prognostic Biomarker in Primary Glioma: A Multi-Cohort Validation Study with Functional Characterization.Int J Mol Sci2026https://conductscience.org/library/papers/42196180PubMed
42,192,946Prediction of Overall Survival in Glioblastoma Using Early Postoperative Reduction in FLAIR Lesion Volume After Gross Total Resection.Cancers (Basel)2026https://conductscience.org/library/papers/42192946PubMed
42,131,790MGMTai: O6-methylguanine-DNA methyltransferase (MGMT) methylation prediction in isocitrate dehydrogenase (IDH)-wild type glioblastoma to direct temozolomide therapy.Neurooncol Adv2026https://conductscience.org/library/papers/42131790PubMed
42,104,024Molecular subtypes and the (in vitro) response of glioblastoma to temozolomide.BJC Rep2026https://conductscience.org/library/papers/42104024PubMed
42,008,029Higher cerebral metabolic rate of oxygen derived from dynamic susceptibility contrast MRI is an independent predictor of poor survival in IDH-wildtype glioblastoma.Neuroradiology2026https://conductscience.org/library/papers/42008029PubMed
41,993,610Translational Models for Glioblastoma: Revolutionizing Drug Development and Personalized Medicine through Clinical Insights.Theranostics2026https://conductscience.org/library/papers/41993610PubMed

1 to 10 of 952

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
MGMT4,255PubTator's text mininghttps://conductscience.org/library/genes/4255

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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