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Paper · 11090108

Inhibitory effects of JTV-519, a novel cardioprotective drug, on potassium currents and experimental atrial fibrillation in guinea-pig hearts.

Nakaya H and 4 others. Br J Pharmacol, 2000. Cited by 48 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Inhibitory effects of JTV-519, a novel cardioprotective drug, on potassium currents and experimental atrial fibrillation in guinea-pig hearts. Papers, record 11090108. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/11090108

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Inhibitory effects of JTV-519, a novel cardioprotective drug, on potassium currents and experimental atrial fibrillation in guinea-pig hearts.
PubMed
Journal
Br J Pharmacol
PubMed
Year
2000
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
48
iCite
Relative citation ratio, by iCite
1.04
iCite
Revised in PubMed
2018-12-11
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Nakaya HH
2Furusawa YY
3Ogura TT
4Tamagawa MM
5Uemura HH

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Atrial FibrillationMajor topic
Cardiovascular AgentsMajor topic
HeartMajor topic
Membrane PotentialsMajor topic
Potassium ChannelsMajor topic
ThiazepinesMajor topic
Action Potentials
Adenosine
Animals
Atrial Function
Calcium Channel Blockers
Carbachol
Dose-Response Relationship, Drug
Guanosine 5'-O-(3-Thiotriphosphate)
Guinea Pigs
Heart Atria
In Vitro Techniques
Receptors, Muscarinic

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References38

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
110,588,929Bepridil differentially inhibits two delayed rectifier K(+) currents, I(Kr) and I(Ks), in guinea-pig ventricular myocytes.Br J Pharmacol1999https://conductscience.org/library/papers/10588929PubMed
28,417,848Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide.Circ Res1993https://conductscience.org/library/papers/8417848PubMed
310,683,355Anti-ischemic effect of a novel cardioprotective agent, JTV519, is mediated through specific activation of delta-isoform of protein kinase C in rat ventricular myocardium.Circulation2000https://conductscience.org/library/papers/10683355PubMed
410,704,162Acute myocardial infarction complicated by atrial fibrillation in the elderly: prevalence and outcomes.Circulation2000https://conductscience.org/library/papers/10704162PubMed
5533,865Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells.J Physiol (Paris)1979https://conductscience.org/library/papers/533865PubMed
68,428,201Antiarrhythmic agents act differently on the activation phase of the ACh-response in guinea-pig atrial myocytes.Br J Pharmacol1993https://conductscience.org/library/papers/8428201PubMed
77,684,298Effects of MS-551, a new class III antiarrhythmic drug, on action potential and membrane currents in rabbit ventricular myocytes.Br J Pharmacol1993https://conductscience.org/library/papers/7684298PubMed
87,516,012Molecular mechanism of cibenzoline-induced anticholinergic action in single atrial myocytes: comparison with effect of disopyramide.J Cardiovasc Pharmacol1994https://conductscience.org/library/papers/7516012PubMed
97,528,835Effects of E-4031 on atrial fibrillation threshold in guinea pig atria: comparative study with class I antiarrhythmic drugs.J Cardiovasc Pharmacol1994https://conductscience.org/library/papers/7528835PubMed
107,758,191Anticholinergic effects of class III antiarrhythmic drugs in guinea pig atrial cells. Different molecular mechanisms.Circulation1995https://conductscience.org/library/papers/7758191PubMed

1 to 10 of 38

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Cited by17

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 48 citations.

PMIDTitleJournalYearIn PapersSource
41,389,127Crosstalk between Ryanodine Receptor 2 Dysfunction and FK506-Binding Proteins in Pulmonary Hypertension.Cardiovasc Drugs Ther2026https://conductscience.org/library/papers/41389127PubMed
40,768,812Pharmacological study of the safety, efficacy, and potential of M201-A on paroxysmal and persistent atrial fibrillation.J Pharmacol Exp Ther2025https://conductscience.org/library/papers/40768812PubMed
36,625,865Role of ryanodine receptor 2 and FK506-binding protein 12.6 dissociation in pulmonary hypertension.J Gen Physiol2023https://conductscience.org/library/papers/36625865PubMed
31,607,952Differential Modulation of IK and ICa,L Channels in High-Fat Diet-Induced Obese Guinea Pig Atria.Front Physiol2019https://conductscience.org/library/papers/31607952PubMed
28,596,175Calcium Signaling and Cardiac Arrhythmias.Circ Res2017https://conductscience.org/library/papers/28596175PubMed
28,181,690Calcium-mediated cellular triggered activity in atrial fibrillation.J Physiol2017https://conductscience.org/library/papers/28181690PubMed
24,733,689New antiarrhythmic targets to control intracellular calcium handling.Neth Heart J2014https://conductscience.org/library/papers/24733689PubMed
22,932,727The ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisis.Heart Fail Rev2013https://conductscience.org/library/papers/22932727PubMed
22,563,249Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy?Diabetes Metab Syndr Obes2012https://conductscience.org/library/papers/22563249PubMed
21,642,946Targeting ryanodine receptors for anti-arrhythmic therapy.Acta Pharmacol Sin2011https://conductscience.org/library/papers/21642946PubMed

1 to 10 of 17

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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