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Paper · 8428201

Antiarrhythmic agents act differently on the activation phase of the ACh-response in guinea-pig atrial myocytes.

Inomata N and 3 others. Br J Pharmacol, 1993. Cited by 35 papers, by iCite.

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ConductScience Library. Antiarrhythmic agents act differently on the activation phase of the ACh-response in guinea-pig atrial myocytes. Papers, record 8428201. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8428201

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Antiarrhythmic agents act differently on the activation phase of the ACh-response in guinea-pig atrial myocytes.
PubMed
Journal
Br J Pharmacol
PubMed
Year
1993
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
35
iCite
Relative citation ratio, by iCite
1.07
iCite
Revised in PubMed
2019-05-12
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Inomata NN
2Ohno TT
3Ishihara TT
4Akaike NN

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AcetylcholineMajor topic
Anti-Arrhythmia AgentsMajor topic
MyocardiumMajor topic
PotassiumMajor topic
Potassium ChannelsMajor topic
Animals
Disopyramide
Electric Conductivity
Flecainide
Guinea Pigs
Lidocaine
Male
Propafenone

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References23

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,449,982Ionic pores, gates, and gating currents.Q Rev Biophys1974https://conductscience.org/library/papers/4449982PubMed
21,810,589Mechanisms of the anticholinergic effect of SUN 1165 in comparison with flecainide, disopyramide and quinidine in single atrial myocytes isolated from guinea-pig.Br J Pharmacol1991https://conductscience.org/library/papers/1810589PubMed
3884,018Dual effect of disopyramide on atrial and atrioventricular conduction and refractory periods.Br Heart J1977https://conductscience.org/library/papers/884018PubMed
4660,160The calcium current of Helix neuron.J Gen Physiol1978https://conductscience.org/library/papers/660160PubMed
5574,950A kinetic model for the muscarinic action of acetylcholine.Pflugers Arch1979https://conductscience.org/library/papers/574950PubMed
67,192,183Anticholinergic effects of disopyramide and quinidine on guinea pig myocardium. Mediation by direct muscarinic receptor blockade.Circ Res1980https://conductscience.org/library/papers/7192183PubMed
76,262,708The time course of the muscarinic response to ionophoretic acetylcholine application to the S-A node of the rabbit heart.Pflugers Arch1981https://conductscience.org/library/papers/6262708PubMed
82,413,367GTP-binding proteins couple cardiac muscarinic receptors to a K channel.Nature1985https://conductscience.org/library/papers/2413367PubMed
92,413,368Uncoupling of cardiac muscarinic and beta-adrenergic receptors from ion channels by a guanine nucleotide analogue.Nature1985https://conductscience.org/library/papers/2413368PubMed
102,419,304
Canine digitalis arrhythmia as a model for detecting Na-channel blocking antiarrhythmic drugs: a comparative study using other canine arrhythmia models and the new antiarrhythmic drugs, propafenone, tocainide, and SUN 1165.
Heart Vessels1985https://conductscience.org/library/papers/2419304PubMed

1 to 10 of 23

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Cited by10

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 35 citations.

PMIDTitleJournalYearIn PapersSource
33,514,068In Silico Assessment of Class I Antiarrhythmic Drug Effects on Pitx2-Induced Atrial Fibrillation: Insights from Populations of Electrophysiological Models of Human Atrial Cells and Tissues.Int J Mol Sci2021https://conductscience.org/library/papers/33514068PubMed
32,453,071The Small Conductance Calcium-Activated Potassium Channel Inhibitors NS8593 and UCL1684 Prevent the Development of Atrial Fibrillation Through Atrial-Selective Inhibition of Sodium Channel Activity.J Cardiovasc Pharmacol2020https://conductscience.org/library/papers/32453071PubMed
22,706,581A fluorescent screening assay for identifying modulators of GIRK channels.J Vis Exp2012https://conductscience.org/library/papers/22706581PubMed
22,059,075Targeting GIRK Channels for the Development of New Therapeutic Agents.Front Pharmacol2011https://conductscience.org/library/papers/22059075PubMed
19,760,273Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillation.Naunyn Schmiedebergs Arch Pharmacol2010https://conductscience.org/library/papers/19760273PubMed
11,090,108Inhibitory effects of JTV-519, a novel cardioprotective drug, on potassium currents and experimental atrial fibrillation in guinea-pig hearts.Br J Pharmacol2000https://conductscience.org/library/papers/11090108PubMed
11,015,309The bee venom peptide tertiapin underlines the role of I(KACh) in acetylcholine-induced atrioventricular blocks.Br J Pharmacol2000https://conductscience.org/library/papers/11015309PubMed
10,188,988Inhibitory effects of aprindine on the delayed rectifier K+ current and the muscarinic acetylcholine receptor-operated K+ current in guinea-pig atrial cells.Br J Pharmacol1999https://conductscience.org/library/papers/10188988PubMed
8,750,919Interaction of class III antiarrhythmic drugs with muscarinic M2 and M3 receptors: radioligand binding and functional studies.Naunyn Schmiedebergs Arch Pharmacol1995https://conductscience.org/library/papers/8750919PubMed
8,591,000SD-3212, a new class I and IV antiarrhythmic drug: a potent inhibitor of the muscarinic acetylcholine-receptor-operated potassium current in guinea-pig atrial cells.Br J Pharmacol1995https://conductscience.org/library/papers/8591000PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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