Paper · 7192183

Anticholinergic effects of disopyramide and quinidine on guinea pig myocardium. Mediation by direct muscarinic receptor blockade.

Mirro MJ and 3 others. Circ Res, 1980. Cited by 104 papers, by iCite.

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ConductScience Library. Anticholinergic effects of disopyramide and quinidine on guinea pig myocardium. Mediation by direct muscarinic receptor blockade. Papers, record 7192183. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/7192183

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Anticholinergic effects of disopyramide and quinidine on guinea pig myocardium. Mediation by direct muscarinic receptor blockade.; PubMed
Journal: Circ Res; PubMed
Year: 1980; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/7192183/; PubMed
DOI: https://doi.org/10.1161/01.res.47.6.855; PubMed
The journal: https://conductscience.org/library/journal-index/0047103; PubMed
Citations, by iCite: 104; iCite
Relative citation ratio, by iCite: 4.39; iCite
Revised in PubMed: 2019-07-06; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Mirro MJ	M J
2	Manalan AS	A S
3	Bailey JC	J C
4	Watanabe AM	A M

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Disopyramide	Major topic
Myocardium	Major topic
Parasympatholytics	Major topic
Pyridines	Major topic
Quinidine	Major topic
Animals
Atropine
Female
Guinea Pigs
Heart Atria
Male
Physostigmine
Procainamide
Receptors, Muscarinic
Time Factors

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
HL06308	NHLBI NIH HHS	United States		PubMed	PubMed
HL18538	NHLBI NIH HHS	United States	R01HL018538	PubMed and NIH	NIH RePORTER
HL18795	NHLBI NIH HHS	United States	R01HL018795	PubMed and NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by20

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 104 citations.

PMID	Title	Journal	Year	In Papers	Source
33,154,722	Ionic Mechanisms of Disopyramide Prolonging Action Potential Duration in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1.	Front Pharmacol	2020	https://conductscience.org/library/papers/33154722	PubMed
8,750,919	Interaction of class III antiarrhythmic drugs with muscarinic M2 and M3 receptors: radioligand binding and functional studies.	Naunyn Schmiedebergs Arch Pharmacol	1995	https://conductscience.org/library/papers/8750919	PubMed
8,428,201	Antiarrhythmic agents act differently on the activation phase of the ACh-response in guinea-pig atrial myocytes.	Br J Pharmacol	1993	https://conductscience.org/library/papers/8428201	PubMed
7,093,588	Electrophysiological and other effects on rabbit hearts of CCI22277, a new steroidal antiarrhythmic drug.	Br J Pharmacol	1982	https://conductscience.org/library/papers/7093588	PubMed
6,979,043	Reciprocal modulation of agonist and antagonist binding to muscarinic cholinergic receptor by guanine nucleotide.	Proc Natl Acad Sci U S A	1982	https://conductscience.org/library/papers/6979043	PubMed
6,704,576	Antimuscarinic action of quinidine on the heart? A study in myocardial preparations from cat hearts.	Br J Pharmacol	1984	https://conductscience.org/library/papers/6704576	PubMed
3,772,736	In vivo interaction of the enantiomers of disopyramide in human subjects.	J Pharmacokinet Biopharm	1986	https://conductscience.org/library/papers/3772736	PubMed
3,513,881	Comparison of the parasympatholytic activity of ACC-9358 and disopyramide.	Br J Pharmacol	1986	https://conductscience.org/library/papers/3513881	PubMed
2,582,418	Batrachotoxin changes the properties of the muscarinic receptor in rat brain and heart: possible interaction(s) between muscarinic receptors and sodium channels.	Proc Natl Acad Sci U S A	1985	https://conductscience.org/library/papers/2582418	PubMed
2,436,062	Quinidine inhibition of the muscarine receptor-activated K+ channel current in atrial cells of guinea pig.	Naunyn Schmiedebergs Arch Pharmacol	1987	https://conductscience.org/library/papers/2436062	PubMed

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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