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Paper · 3772736

In vivo interaction of the enantiomers of disopyramide in human subjects.

Giacomini KM and 5 others. J Pharmacokinet Biopharm, 1986. Cited by 59 papers, by iCite.

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ConductScience Library. In vivo interaction of the enantiomers of disopyramide in human subjects. Papers, record 3772736. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/3772736

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
In vivo interaction of the enantiomers of disopyramide in human subjects.
PubMed
Journal
J Pharmacokinet Biopharm
PubMed
Year
1986
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
59
iCite
Relative citation ratio, by iCite
4.08
iCite
Revised in PubMed
2019-10-22
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Giacomini KMK M
2Nelson WLW L
3Pershe RAR A
4Valdivieso LL
5Turner-Tamiyasu KK
6Blaschke TFT F

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
DisopyramideMajor topic
Adult
Deuterium
Humans
Kinetics
Male
Mass Spectrometry
Software
Stereoisomerism

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
GM22209NIGMS NIH HHSUnited StatesR01GM022209PubMed and NIHNIH RePORTER
GM31254NIGMS NIH HHSUnited StatesR01GM031254PubMed and NIHNIH RePORTER
RR70NCRR NIH HHSUnited StatesPubMedPubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References25

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
17,138,760Calculation of drug concentration in plasma after equilibrium dialysis.Br J Clin Pharmacol1982https://conductscience.org/library/papers/7138760PubMed
2681,482Assay of disopyramide in plasma by high-pressure liquid chromatography.J Chromatogr1978https://conductscience.org/library/papers/681482PubMed
37,226,447Electrophysiological effects of the optical isomers of disopyramide and quinidine in the dog. Dependence on stereochemistry.Circ Res1981https://conductscience.org/library/papers/7226447PubMed
4458,555Role of concentration-dependent plasma protein binding in disopyramide disposition.J Pharmacokinet Biopharm1979https://conductscience.org/library/papers/458555PubMed
56,482,678Stereoselective binding of disopyramide to human plasma protein.Life Sci1984https://conductscience.org/library/papers/6482678PubMed
6553,329Therapeutic drug monitoring: an overview.Ther Drug Monit1979https://conductscience.org/library/papers/553329PubMed
7552,861The renal clearance of disopyramide after bolus intravenous injection.Biopharm Drug Dispos1979https://conductscience.org/library/papers/552861PubMed
87,192,183Anticholinergic effects of disopyramide and quinidine on guinea pig myocardium. Mediation by direct muscarinic receptor blockade.Circ Res1980https://conductscience.org/library/papers/7192183PubMed
97,373,556Effect of plasma protein binding on renal clearance of drugs.J Pharm Sci1980https://conductscience.org/library/papers/7373556PubMed
107,299,695Concentration-dependence of disopyramide binding to plasma protein and its influence on kinetics and dynamics.J Pharmacol Exp Ther1981https://conductscience.org/library/papers/7299695PubMed

1 to 10 of 25

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Cited by13

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 59 citations.

PMIDTitleJournalYearIn PapersSource
12,102,640Impact of stereoselectivity on the pharmacokinetics and pharmacodynamics of antiarrhythmic drugs.Clin Pharmacokinet2002https://conductscience.org/library/papers/12102640PubMed
9,803,978Therapeutic drug monitoring: antiarrhythmic drugs.Br J Clin Pharmacol1998https://conductscience.org/library/papers/9803978PubMed
9,706,057Enantioselective tissue distribution of the basic drugs disopyramide, flecainide and verapamil in rats: role of plasma protein and tissue phosphatidylserine binding.Pharm Res1998https://conductscience.org/library/papers/9706057PubMed
9,260,035Bioequivalence of chiral drugs. Stereospecific versus non-stereospecific methods.Clin Pharmacokinet1997https://conductscience.org/library/papers/9260035PubMed
8,485,501Development and registration of chiral drugs.Pharm World Sci1993https://conductscience.org/library/papers/8485501PubMed
8,415,403Stereoselective interactions of organic cations with the organic cation transporter in OK cells.Pharm Res1993https://conductscience.org/library/papers/8415403PubMed
3,242,583Stereoselective drug disposition: potential for misinterpretation of drug disposition data.Br J Clin Pharmacol1988https://conductscience.org/library/papers/3242583PubMed
2,200,681Stereoselectivity in clinical pharmacokinetics and drug development.Eur J Drug Metab Pharmacokinet1990https://conductscience.org/library/papers/2200681PubMed
2,185,905Chirality. Clinical pharmacokinetic and pharmacodynamic considerations.Clin Pharmacokinet1990https://conductscience.org/library/papers/2185905PubMed
2,044,328Nonlinear pharmacokinetics: clinical Implications.Clin Pharmacokinet1991https://conductscience.org/library/papers/2044328PubMed

1 to 10 of 13

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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