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Paper · 458555

Role of concentration-dependent plasma protein binding in disopyramide disposition.

Meffin PJ and 5 others. J Pharmacokinet Biopharm, 1979. Cited by 168 papers, by iCite.

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ConductScience Library. Role of concentration-dependent plasma protein binding in disopyramide disposition. Papers, record 458555. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/458555

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Role of concentration-dependent plasma protein binding in disopyramide disposition.
PubMed
Journal
J Pharmacokinet Biopharm
PubMed
Year
1979
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
168
iCite
Relative citation ratio, by iCite
10.1
iCite
Revised in PubMed
2019-10-21
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Meffin PJP J
2Robert EWE W
3Winkle RAR A
4Harapat SS
5Peters FAF A
6Harrison DCD C

Source PubMed

Topics7

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Blood ProteinsMajor topic
DisopyramideMajor topic
PyridinesMajor topic
Humans
Kinetics
Models, Biological
Protein Binding

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References16

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,026,530Correlation of disopyramide pharmacokinetics with efficacy in ventricular tachyarrhythmia.J Int Med Res1976https://conductscience.org/library/papers/1026530PubMed
21,026,537Anti-arrhythmic and haemodynamic effects of intravenous and oral disopyramide in patients with ventricular arrhythmia.J Int Med Res1976https://conductscience.org/library/papers/1026537PubMed
31,090,217The pharmacokinetics of Norpace.Angiology1975https://conductscience.org/library/papers/1090217PubMed
55,454,949Binding of anilide-type local anesthetics in human plasma. I. Relationships between binding, physicochemical properties, and anesthetic activity.Anesthesiology1970https://conductscience.org/library/papers/5454949PubMed
6978,389Pharmacokinetics of the antiarrhythmic disopyramide in healthy humans.J Pharmacokinet Biopharm1976https://conductscience.org/library/papers/978389PubMed
71,026,529The pharmacokinetics of disopyramide following myocardial infarction with special reference to oral and intravenous dose regimens.J Int Med Res1976https://conductscience.org/library/papers/1026529PubMed
81,003,329
Linear pharmacokinetic equations allowing direct calculation of many needed pharmacokinetic parameters from the coefficients and exponents of polyexponential equations which have been fitted to the data.
J Pharmacokinet Biopharm1976https://conductscience.org/library/papers/1003329PubMed
921,054The effects of urine pH and plasma protein binding on the renal clearance of disopyramide.Clin Pharmacokinet1977https://conductscience.org/library/papers/21054PubMed
104,104,224Disopyramide phosphate: pharmacokinetic and pharmacologic relationships of a new antiarrhythmic agent.Arch Int Pharmacodyn Ther1971https://conductscience.org/library/papers/4104224PubMed
114,427,218Statistical estimations in pharmacokinetics.J Pharmacokinet Biopharm1974https://conductscience.org/library/papers/4427218PubMed

1 to 10 of 16

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Cited by53

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 168 citations.

PMIDTitleJournalYearIn PapersSource
36,583,819Gut microbiota and cardiac arrhythmia: a pharmacokinetic scope.Egypt Heart J2022https://conductscience.org/library/papers/36583819PubMed
30,151,907Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative.Clin Pharmacol Ther2019https://conductscience.org/library/papers/30151907PubMed
12,844,326Therapeutic drug monitoring of antiarrhythmic drugs.Clin Pharmacokinet2003https://conductscience.org/library/papers/12844326PubMed
9,803,978Therapeutic drug monitoring: antiarrhythmic drugs.Br J Clin Pharmacol1998https://conductscience.org/library/papers/9803978PubMed
9,258,628Adverse effects of class I antiarrhythmic drugs.Drug Saf1997https://conductscience.org/library/papers/9258628PubMed
7,437,241Pharmacokinetics of oral disopyramide phosphate in patients with renal impairment.Br J Clin Pharmacol1980https://conductscience.org/library/papers/7437241PubMed
7,431,218Modeling of drug response in individual subjects.J Pharmacokinet Biopharm1980https://conductscience.org/library/papers/7431218PubMed
7,387,819Plasma binding of disopyramide.Br J Clin Pharmacol1980https://conductscience.org/library/papers/7387819PubMed
7,363,933Comparative bioavailability of disopyramide after multiple dosing with standard capsules and controlled-release tablets.Eur J Clin Pharmacol1980https://conductscience.org/library/papers/7363933PubMed
7,259,930Plasma concentrations and protein binding of disopyramide and mono-N-dealkyldisopyramide during chronic oral disopyramide therapy.Br J Clin Pharmacol1981https://conductscience.org/library/papers/7259930PubMed

1 to 10 of 53

See all 53 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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