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Paper12245

Specific transplantation tolerance induced by autoimmunization against the individual's own, naturally occurring idiotypic, antigen-binding receptors.

Binz H and 1 other. J Exp Med, 1976. Cited by 118 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Specific transplantation tolerance induced by autoimmunization against the individual's own, naturally occurring idiotypic, antigen-binding receptors. Papers, record 12245. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/12245

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Specific transplantation tolerance induced by autoimmunization against the individual's own, naturally occurring idiotypic, antigen-binding receptors.
PubMed
Journal
J Exp Med
PubMed
Year
1976
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
118
iCite
Relative citation ratio, by iCite
2.93
iCite
Revised in PubMed
2019-05-08
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Binz HH
2Wigzell HH

Source PubMed

Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antibodies, Anti-IdiotypicMajor topic
AutoantibodiesMajor topic
Histocompatibility AntigensMajor topic
Immune ToleranceMajor topic
Immunity, CellularMajor topic
Immunoglobulin AllotypesMajor topic
LymphocytesMajor topic
Animals
B-Lymphocytes
Binding Sites
Graft vs Host Reaction
Immunization
Lymphocyte Culture Test, Mixed
Rats
Rats, Inbred Strains
T-Lymphocytes

Source PubMed

References18

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
114,450,081Preparation of iodine-131 labelled human growth hormone of high specific activity.Nature1962https://conductscience.org/library/papers/14450081PubMed
2235,004Early cellular events in a systemic graft-vs.-host reaction. II. Autoradiographic estimates of the frequency of donor lymphocytes which respond to each Ag-B-determined antigenic complex.J Exp Med1975https://conductscience.org/library/papers/235004PubMed
34,130,243Studies of idiotypic antibodies. Production and characterization of autoantiidiotypic antisera.J Exp Med1974https://conductscience.org/library/papers/4130243PubMed
44,137,861Neonatal tolerance induced by antibody against antigen-specific receptor.Science1974https://conductscience.org/library/papers/4137861PubMed
54,137,934Specific positive selection of lymphocytes reactive to strong histocompatibility antigens.J Exp Med1974https://conductscience.org/library/papers/4137934PubMed
64,153,293Cell-bound receptors for alloantigens on normal lymphocytes. II. Antialloantibody serum contains specific factors reacting with relevant immunocompetent T lymphocytes.J Exp Med1974https://conductscience.org/library/papers/4153293PubMed
74,205,351Biosynthesis of immunoglobulin A (IgA). Secretion and addition of carbohydrate to monomer and polymer forms of a mouse myeloma protein.Biochem J1973https://conductscience.org/library/papers/4205351PubMed
84,214,865Anti-idiotypic antibody in rat transplantation immunity. I. Production of anti-idiotypic antibody in animals repeatedly immunized with alloantigens.J Immunol1974https://conductscience.org/library/papers/4214865PubMed
94,394,274A lymph node weight assay for the graft-versus-host activity of rat lymphoid cells.Transplantation1970https://conductscience.org/library/papers/4394274PubMed
104,551,691Immune responses in vitro. I. Culture conditions for antibody synthesis.Cell Immunol1972https://conductscience.org/library/papers/4551691PubMed
1150,400
Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. I. Demonstration of similar or identical idiotypes on IgG molecules and T-cell receptors with specificity for the same alloantigens.
J Exp Med1975https://conductscience.org/library/papers/50400PubMed
1252,186
Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. IV. Isolation of two groups of naturally occurring, idiotypic molecules with specific antigen-binding activity in the serum and urine of normal rats.
Scand J Immunol1975https://conductscience.org/library/papers/52186PubMed
1353,259
Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. II. Determination of frequency and characteristics of idiotypic T and B lymphocytes in normal rats using direct visualization.
J Exp Med1975https://conductscience.org/library/papers/53259PubMed
145,347,693Quantitative investigations of idiotypic antibodies. I. Analysis of precipitating antibody populations.J Exp Med1969https://conductscience.org/library/papers/5347693PubMed
155,378,377Immunoglobulin M biosynthesis. Intracellular accumulation of 7S subunits.Biochem J1969https://conductscience.org/library/papers/5378377PubMed
165,682,942Quantitative studies on the mixed lymphocyte interaction in rats. 3. Kinetics of the response.J Exp Med1968https://conductscience.org/library/papers/5682942PubMed
1760,781
Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. V. Biochemical and serological characteristics of naturally occurring, soluble antigen-binding T-lymphocyte-derived molecules.
Scand J Immunol1976https://conductscience.org/library/papers/60781PubMed
18958,374Successful induction of specific tolerance to transplantation antigens using autoimmunisation against the recipient's own natural antibodies.Nature1976https://conductscience.org/library/papers/958374PubMed

Cited by28

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 118 citations.

PMIDTitleJournalYearIn PapersSource
15,541,175Antigenized antibodies expressing Vbeta8.2 TCR peptides immunize against rat experimental allergic encephalomyelitis.J Immune Based Ther Vaccines2004https://conductscience.org/library/papers/15541175PubMed
15,520,851Homeostatic control of immunity by TCR peptide-specific Tregs.J Clin Invest2004https://conductscience.org/library/papers/15520851PubMed
8,432,846Prolongation of survival of rat cardiac allografts by T cell vaccination.J Clin Invest1993https://conductscience.org/library/papers/8432846PubMed
6,978,921Helper T cell recognition of the variable domains of a mouse myeloma protein (315). Effect of the major histocompatibility complex and domain conformation.J Exp Med1982https://conductscience.org/library/papers/6978921PubMed
6,764,838Mechanisms of idiotype suppression: role of anti-idiotype antibody.Surv Immunol Res1982https://conductscience.org/library/papers/6764838PubMed
6,454,747Regulation by complementary idiotypes. Ig protects the clone producing it.J Exp Med1981https://conductscience.org/library/papers/6454747PubMed
6,448,806Non-specific inhibitory processes of immunological and mitogenic cellular responses.Immunology1980https://conductscience.org/library/papers/6448806PubMed
6,445,395Antigen- and receptor-driven regulatory mechanisms. III. Induction of delayed type hypersensitivity to azobenzenearsonate with anti-cross-reactive idiotypic antibodies.J Exp Med1980https://conductscience.org/library/papers/6445395PubMed
6,174,665Antigen receptors on murine T lymphocytes in contact sensitivity. III. Mechanism of negative feedback regulation by auto-anti-idiotypic antibody.J Exp Med1982https://conductscience.org/library/papers/6174665PubMed
6,172,375Microheterogeneity in regulatory circuits for T-cell alloresponsiveness.Immunology1981https://conductscience.org/library/papers/6172375PubMed
6,154,768
Antigen receptors on major histocompatibility complex-restricted T lymphocytes. I. Preparation and characterization of syngeneic antisera against trinitrophenyl-activated T cell blasts and demonstration of their specificity for idiotypes on cytotoxic T lymphocytes.
J Exp Med1980https://conductscience.org/library/papers/6154768PubMed
2,444,527The role of an anti-idiotype antibody in regulating hapten (azobenzenearsonate)-specific granuloma formation.Immunology1987https://conductscience.org/library/papers/2444527PubMed
2,416,677A role for self-recognizing T cells in the regulation of antibody-forming and cell-mediated cytotoxic responses in the mouse.Immunology1985https://conductscience.org/library/papers/2416677PubMed
364,296Successful cardiac allografts in syngeneic radiation chimeras.Mol Cell Biochem1978https://conductscience.org/library/papers/364296PubMed
312,909Autoregulation of an antibody response via network-induced auto-anti-idiotype.J Exp Med1979https://conductscience.org/library/papers/312909PubMed
312,903
Production of auto-anti-idiotypic antibody during the normal immune response to TNP-ficoll. I. Occurrence in AKR/J and BALB/c mice of hapten-augmentable, anti-TNP plaque-forming cells and their accelerated appearance in recipients of immune spleen cells.
J Exp Med1979https://conductscience.org/library/papers/312903PubMed
304,882Induction of specific transplantation immune reactions using anti-idiotypic antibodies.J Exp Med1978https://conductscience.org/library/papers/304882PubMed
302,312
Induction of specific immune unresponsiveness using purified mixed leukocyte culture-activated T lymphoblasts as autoimmunogen. I. Demonstration of general validity as to species and histocompatibility barriers.
J Exp Med1977https://conductscience.org/library/papers/302312PubMed
147,301Transplantation tolerance in adult rats using total lymphoid irradiation: permanent survival of skin, heart, and marrow allografts.J Exp Med1978https://conductscience.org/library/papers/147301PubMed
144,773Lymphocyte transformation induced by autologous cells. V. Generation of immunologic memory and specificity during the autologous mixed lymphocyte reaction.J Exp Med1977https://conductscience.org/library/papers/144773PubMed

See all 28 cited by

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

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  • ClinicalTrials.govNo license stated
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  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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