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Paper312909

Autoregulation of an antibody response via network-induced auto-anti-idiotype.

Brown JC and 1 other. J Exp Med, 1979. Cited by 75 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Autoregulation of an antibody response via network-induced auto-anti-idiotype. Papers, record 312909. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/312909

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Autoregulation of an antibody response via network-induced auto-anti-idiotype.
PubMed
Journal
J Exp Med
PubMed
Year
1979
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
75
iCite
Relative citation ratio, by iCite
1.93
iCite
Revised in PubMed
2019-05-08
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Brown JCJ C
2Rodkey LSL S

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antibodies, Anti-IdiotypicMajor topic
Antibody FormationMajor topic
AutoantibodiesMajor topic
Immunoglobulin IdiotypesMajor topic
Animals
Antigen-Antibody Complex
Binding Sites
Homeostasis
Immunoglobulin Fc Fragments
Immunoglobulin G
Micrococcus
Rabbits
Rheumatoid Factor
T-Lymphocytes

Source PubMed

References38

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
112,245Specific transplantation tolerance induced by autoimmunization against the individual's own, naturally occurring idiotypic, antigen-binding receptors.J Exp Med1976https://conductscience.org/library/papers/12245PubMed
248,249Antibodies reactive with cell surface carbohydrates.Proc Natl Acad Sci U S A1975https://conductscience.org/library/papers/48249PubMed
352,186
Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. IV. Isolation of two groups of naturally occurring, idiotypic molecules with specific antigen-binding activity in the serum and urine of normal rats.
Scand J Immunol1975https://conductscience.org/library/papers/52186PubMed
461,876Sharing of idiotypic specificities between different antibody populations from an individual rabbit.Eur J Immunol1975https://conductscience.org/library/papers/61876PubMed
566,783Idiotypic determinants of rabbit B- and T-derived lymphocytes.Immunol Rev1977https://conductscience.org/library/papers/66783PubMed
671,240
Isolated hapten-binding receptors of sensitized lymphocytes. I. Receptors from nylon wool-enriched mouse T lymphocytes lack serological markers of immunoglobulin constant domains but express heavy chain variable portions.
Eur J Immunol1977https://conductscience.org/library/papers/71240PubMed
785,681Cellular basis of regulation of expression of idiotype. I. T-suppressor cells specific for MOPC 460 idiotype regulate the expression of cells secreting anti-TNP antibodies bearing 460 idiotype.J Exp Med1979https://conductscience.org/library/papers/85681PubMed
8126,553Rheumatoid factor appearance in Micrococcus lysodeikticus immunization and its interference with allotype specific reactions.Z Immunitatsforsch Exp Klin Immunol1975https://conductscience.org/library/papers/126553PubMed
9270,748Idiotypic-anti-idiotypic regulation of antibody synthesis in rabbits.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/270748PubMed
10303,775Idiotypic regulation of the immune system by the induction of antibodies against anti-idiotypic antibodies.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/303775PubMed
11338,486Autoantibodies detected in rabbits hyperimmunized with group A, C, and G streptococcal vaccines.Infect Immun1977https://conductscience.org/library/papers/338486PubMed
12598,868Restricted heterogeneity of antibodies to idiotypes of isologous immunoglobulins.Immunochemistry1977https://conductscience.org/library/papers/598868PubMed
13915,288Immune response to phosphorylcholine. III. Requirement of the Fc portion and equal effectiveness of IgG subclasses in anti-receptor antibody-induced suppression.J Immunol1977https://conductscience.org/library/papers/915288PubMed
141,085,701Detection of anti-idiotype reactive cells in the response to phosphorylcholine.Eur J Immunol1976https://conductscience.org/library/papers/1085701PubMed
151,102,604Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A.J Immunol1975https://conductscience.org/library/papers/1102604PubMed
164,110,016Quantitative investigations of idiotypic antibodies. VI. Idiotypic specificity as a potential genetic marker for the variable regions of mouse immunoglobulin polypeptide chains.J Exp Med1972https://conductscience.org/library/papers/4110016PubMed
174,126,769Homogenous rabbit 7S anti-IgG with antibody specificity for peptidoglycan.J Exp Med1973https://conductscience.org/library/papers/4126769PubMed
184,129,807Immunoglobulin structure: amino terminal sequences of mouse myeloma proteins that bind phosphorylcholine.Science1974https://conductscience.org/library/papers/4129807PubMed
194,130,243Studies of idiotypic antibodies. Production and characterization of autoantiidiotypic antisera.J Exp Med1974https://conductscience.org/library/papers/4130243PubMed
204,137,513A rabbit with the allotypic phenotype: ala2a3 b4b5b6.J Immunol1974https://conductscience.org/library/papers/4137513PubMed

See all 38 references

Cited by21

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 75 citations.

PMIDTitleJournalYearIn PapersSource
24,285,974Altered immune regulation in type 1 diabetes.Clin Dev Immunol2013https://conductscience.org/library/papers/24285974PubMed
7,944,339Antibody synthesis induced by endogenous internal images.Appl Biochem Biotechnol1994https://conductscience.org/library/papers/7944339PubMed
7,399,707Complement activation induced by rabbit rheumatoid factor.Infect Immun1980https://conductscience.org/library/papers/7399707PubMed
7,299,346Idiotypy of clonal responses to influenza virus hemagglutinin.J Exp Med1981https://conductscience.org/library/papers/7299346PubMed
7,252,415Idiotype-anti-idiotype regulation. I. Immunization with a levan-binding myeloma protein leads to the appearance of auto-anti-(anti-idiotype) antibodies and to the activation of silent clones.J Exp Med1981https://conductscience.org/library/papers/7252415PubMed
7,051,837Autoimmune diseases: immunopathology and etiopathogenesis.Am J Pathol1982https://conductscience.org/library/papers/7051837PubMed
6,976,356
Production of antibodies specific for Fc, Fab', and streptokinase-streptodornase in vitro by peripheral blood cells from patients with rheumatoid arthritis and normal donors. Identification of immune complexes in culture supernatants containing hidden antibodies reactive with Fab' fragments of immunoglobulin G.
J Clin Invest1982https://conductscience.org/library/papers/6976356PubMed
6,971,876Network theory in autoimmunity. In vitro suppression of serum anti-DNA antibody binding to DNA by anti-idiotypic antibody in systemic lupus erythematosus.J Clin Invest1981https://conductscience.org/library/papers/6971876PubMed
6,854,211Regulation of natural antiallotype antibody responses by idiotype network-induced auto-antiidiotypic antibodies.J Exp Med1983https://conductscience.org/library/papers/6854211PubMed
6,767,740Regulation of monoclonal immunoglobulin G synthesis by antiidiotypic antibody in a patient with hypogammaglobulinemia.J Clin Invest1980https://conductscience.org/library/papers/6767740PubMed
6,697,565Idiotypic network: possible explanation of seronegativity in a patient with rheumatoid arthritis.Clin Exp Immunol1984https://conductscience.org/library/papers/6697565PubMed
6,603,934
Characterization of anti-Fab' antibodies in human sera: identification of soluble immune complexes that contain hidden anti-KLH and blocking anti-immunoglobulins following immunization with keyhole limpet haemocyanin.
Clin Exp Immunol1983https://conductscience.org/library/papers/6603934PubMed
6,196,779Polypeptides immunologically related to band 3 are present in nucleated somatic cells.Proc Natl Acad Sci U S A1983https://conductscience.org/library/papers/6196779PubMed
6,193,223Antiidiotype stimulation of antigen-specific antigen-independent antibody responses in vitro. I. Evidence for stimulation of helper T lymphocyte function.J Exp Med1983https://conductscience.org/library/papers/6193223PubMed
6,185,837Antigenicity, storage, and aging: physiologic autoantibodies to cell membrane and serum proteins and the senescent cell antigen.Mol Cell Biochem1982https://conductscience.org/library/papers/6185837PubMed
6,180,120Naturally induced auto-anit-idiotypic antibodies. Induction by identical idiotopes in some members of an outbred rabbit family.J Exp Med1982https://conductscience.org/library/papers/6180120PubMed
6,179,088Enhancing antibody: a novel component of the immune response.Proc Natl Acad Sci U S A1982https://conductscience.org/library/papers/6179088PubMed
6,163,071Autoregulation of immune responses via idiotype network interactions.Microbiol Rev1980https://conductscience.org/library/papers/6163071PubMed
3,935,669Network interactions in Schistosoma japonicum infection. Identification and characterization of a serologically distinct immunoregulatory auto-antiidiotypic antibody population.J Clin Invest1985https://conductscience.org/library/papers/3935669PubMed
3,182,070Differential regulation of in vitro humoral and cellular immune responsiveness in Brugia pahangi-infected jirds.Infect Immun1988https://conductscience.org/library/papers/3182070PubMed

See all 21 cited by

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

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  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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