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Paper6971876

Network theory in autoimmunity. In vitro suppression of serum anti-DNA antibody binding to DNA by anti-idiotypic antibody in systemic lupus erythematosus.

Abdou NI and 4 others. J Clin Invest, 1981. Cited by 301 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Network theory in autoimmunity. In vitro suppression of serum anti-DNA antibody binding to DNA by anti-idiotypic antibody in systemic lupus erythematosus. Papers, record 6971876. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6971876

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Network theory in autoimmunity. In vitro suppression of serum anti-DNA antibody binding to DNA by anti-idiotypic antibody in systemic lupus erythematosus.
PubMed
Journal
J Clin Invest
PubMed
Year
1981
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
301
iCite
Relative citation ratio, by iCite
9.81
iCite
Revised in PubMed
2019-06-06
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Abdou NIN I
2Wall HH
3Lindsley HBH B
4Halsey JFJ F
5Suzuki TT

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antibodies, AntinuclearMajor topic
Autoimmune DiseasesMajor topic
DNAMajor topic
Immune ToleranceMajor topic
Immunoglobulin IdiotypesMajor topic
Lupus Erythematosus, SystemicMajor topic
Antigen-Antibody Complex
Complement Activating Enzymes
Complement C1q
Humans
Immunoglobulin Fragments
Tetanus Toxoid

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
AI-15360NIAID NIH HHSUnited StatesP50AI015360PubMed and NIHNIH RePORTER
AI-15880NIAID NIH HHSUnited StatesR01AI015880PubMed and NIHNIH RePORTER

References29

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
16,444,664Feedback suppression of the immune response in vitro. II. IgVH-restricted antibody-dependent suppression.J Exp Med1980https://conductscience.org/library/papers/6444664PubMed
26,101,848H gene theory of inherited autoimmune disease.Lancet1980https://conductscience.org/library/papers/6101848PubMed
311,993,330Induction of T and B cell immunity by anti-idiotypic antibody.Eur J Immunol1975https://conductscience.org/library/papers/11993330PubMed
44,403,565Specific suppression of the antibody response by antibodies to receptors.Proc Natl Acad Sci U S A1972https://conductscience.org/library/papers/4403565PubMed
54,541,466A Millipore filter assay for antibodies to native DNA in sera of patients with systemic lupus erythematosus.Arthritis Rheum1973https://conductscience.org/library/papers/4541466PubMed
64,133,998The roles of T and B lymphocytes in self-tolerance and autoimmunity.Contemp Top Immunobiol1974https://conductscience.org/library/papers/4133998PubMed
74,850,305A simplified method for cyanogen bromide activation of agarose for affinity chromatography.Anal Biochem1974https://conductscience.org/library/papers/4850305PubMed
81,081,549Identification of DNA-binding lymphocytes in patients with systemic lupus erythematosus.J Clin Invest1975https://conductscience.org/library/papers/1081549PubMed
9944,196Circulating and intra-articular immune complexes in patients with rheumatoid arthritis. Correlation of 125I-Clq binding activity with clinical and biological features of the disease.J Clin Invest1976https://conductscience.org/library/papers/944196PubMed
10786,009Cellular origins of autoantibody--a preplexing question.Am J Med1976https://conductscience.org/library/papers/786009PubMed
111,085,685Suppressor T-cell abnormality in idiopathic systemic lupus erythematosus.Clin Immunol Immunopathol1976https://conductscience.org/library/papers/1085685PubMed
121,086,175Null cells in peripheral blood of normals and systemic lupus erythematosus.Clin Immunol Immunopathol1976https://conductscience.org/library/papers/1086175PubMed
13300,090Characterization of DNA used to assay sera for anti-DNA antibodies; determination of the specificities of anti-DNA antibodies in SLE and non-SLE rheumatic disease states.J Immunol1977https://conductscience.org/library/papers/300090PubMed
14355,555Passive hemagglutination and hemolysis tests for the detection of anti-DNA antibody.J Immunol Methods1978https://conductscience.org/library/papers/355555PubMed
15212,088Autoimmunity and the immunologic network.Arthritis Rheum1978https://conductscience.org/library/papers/212088PubMed
16308,952Suppressor-cell dysfunction in systemic lupus erythematosus. Cells involved and in vitro correction.J Clin Invest1978https://conductscience.org/library/papers/308952PubMed
17153,749Studies of immune functions of patients with systemic lupus erythematosus. I. Dysfunction of suppressor T-cell activity related to impaired generation of, rather than response to, suppressor cells.Arthritis Rheum1978https://conductscience.org/library/papers/153749PubMed
18311,787Suppressor-cell antibody in systemic lupus erythematosus. Possible mechanism for suppressor-cell dysfunction.J Clin Invest1979https://conductscience.org/library/papers/311787PubMed
1985,681Cellular basis of regulation of expression of idiotype. I. T-suppressor cells specific for MOPC 460 idiotype regulate the expression of cells secreting anti-TNP antibodies bearing 460 idiotype.J Exp Med1979https://conductscience.org/library/papers/85681PubMed
20312,903
Production of auto-anti-idiotypic antibody during the normal immune response to TNP-ficoll. I. Occurrence in AKR/J and BALB/c mice of hapten-augmentable, anti-TNP plaque-forming cells and their accelerated appearance in recipients of immune spleen cells.
J Exp Med1979https://conductscience.org/library/papers/312903PubMed

See all 29 references

Cited by68

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 301 citations.

PMIDTitleJournalYearIn PapersSource
41,441,690Anti-Idiotypic Antibodies in Immune Regulation and Disease: Therapeutic Promise for Next-Generation Vaccines.Vaccines (Basel)2025https://conductscience.org/library/papers/41441690PubMed
35,586,416Anti-Neuronal Autoantibodies (Cell Surface and Onconeural) and Their Association With Natural Autoantibodies in Synthetic Cannabinoid-Induced Psychosis.Front Psychiatry2022https://conductscience.org/library/papers/35586416PubMed
34,276,673Increased Frequency of Activated Switched Memory B Cells and Its Association With the Presence of Pulmonary Fibrosis in Diffuse Cutaneous Systemic Sclerosis Patients.Front Immunol2021https://conductscience.org/library/papers/34276673PubMed
33,686,540Use of Rescue Therapy with IVIG or Cyclophosphamide in Juvenile Myositis.Curr Rheumatol Rep2021https://conductscience.org/library/papers/33686540PubMed
33,437,514Immunomodulatory potential of anti-idiotypic antibodies for the treatment of autoimmune diseases.Future Sci OA2020https://conductscience.org/library/papers/33437514PubMed
27,375,614Role of Natural Autoantibodies and Natural IgM Anti-Leucocyte Autoantibodies in Health and Disease.Front Immunol2016https://conductscience.org/library/papers/27375614PubMed
22,384,267Anti-idiotypic antibody specific to GAD65 autoantibody prevents type 1 diabetes in the NOD mouse.PLoS One2012https://conductscience.org/library/papers/22384267PubMed
22,288,464Protective role of anti-idiotypic antibodies in autoimmunity--lessons for type 1 diabetes.Autoimmunity2012https://conductscience.org/library/papers/22288464PubMed
19,781,546Comparison of three assays for the detection of GAD65Ab-specific anti-idiotypic antibodies.J Immunol Methods2009https://conductscience.org/library/papers/19781546PubMed
18,611,565Biological response modifiers and infectious diseases: actual and potential therapeutic agents.Int J Antimicrob Agents1994https://conductscience.org/library/papers/18611565PubMed
10,773,923Immunoglobulin therapy in immunohematological disorders.Indian J Pediatr1998https://conductscience.org/library/papers/10773923PubMed
9,227,858Yeast killer systems.Clin Microbiol Rev1997https://conductscience.org/library/papers/9227858PubMed
8,252,808Induction of an anti-Fab, anti-DNA and anti-RNA polymerase I autoantibody response network in rabbits immunized with SLE anti-DNA antibody.Clin Exp Immunol1993https://conductscience.org/library/papers/8252808PubMed
7,275,310Detection and composition of immune complexes in experimental African trypanosomiasis.Infect Immun1981https://conductscience.org/library/papers/7275310PubMed
7,040,591Deposition of idiotype-anti-idiotype immune complexes in renal glomeruli after polyclonal B cell activation.J Exp Med1982https://conductscience.org/library/papers/7040591PubMed
6,979,603Anti-idiotypic antibodies to the Coombs antibody in NZB F1 mice.J Exp Med1982https://conductscience.org/library/papers/6979603PubMed
6,697,565Idiotypic network: possible explanation of seronegativity in a patient with rheumatoid arthritis.Clin Exp Immunol1984https://conductscience.org/library/papers/6697565PubMed
6,609,934False-negative anti-DNA antibody activity in infantile systemic lupus erythematosus (SLE).J Clin Immunol1984https://conductscience.org/library/papers/6609934PubMed
6,607,933Human auto-antiidiotypes regulating T cell-mediated reactivity to tetanus toxoid.J Clin Invest1984https://conductscience.org/library/papers/6607933PubMed
6,484,446DNA antibodies with and without complement-binding ability.Rheumatol Int1984https://conductscience.org/library/papers/6484446PubMed

See all 68 cited by

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Trials
  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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