Paper · 1278445

Anticoagulant activity of heparin: separation of high-activity and low-activity heparin species by affinity chromatography on immobilized antithrombin.

Höök M and 3 others. FEBS Lett, 1976. Cited by 426 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Anticoagulant activity of heparin: separation of high-activity and low-activity heparin species by affinity chromatography on immobilized antithrombin. Papers, record 1278445. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/1278445

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Anticoagulant activity of heparin: separation of high-activity and low-activity heparin species by affinity chromatography on immobilized antithrombin.; PubMed
Journal: FEBS Lett; PubMed
Year: 1976; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/1278445/; PubMed
DOI: https://doi.org/10.1016/0014-5793(76)80592-3; PubMed
The journal: https://conductscience.org/library/journal-index/0155157; PubMed
Citations, by iCite: 426; iCite
Relative citation ratio, by iCite: 14; iCite
Revised in PubMed: 2019-06-20; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Höök M	M
2	Björk I	I
3	Hopwood J	J
4	Lindahl U	U

Source PubMed

Topics7

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Blood Coagulation	Major topic
Heparin	Major topic
Antithrombins
Binding Sites
Chromatography, Affinity
Isoelectric Point
Uronic Acids

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by62

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 426 citations.

PMID	Title	Journal	Year	In Papers	Source
42,509,818	The Content and Location of 3-O-Sulfated Glucosamine Enable Differentiation of Ovine, Bovine and Porcine Heparins.	Biomolecules	2026	https://conductscience.org/library/papers/42509818	PubMed
38,639,475	Heparan sulfates and heparan sulfate proteoglycans in hematopoiesis.	Blood	2024	https://conductscience.org/library/papers/38639475	PubMed
38,338,654	M6229 Protects against Extracellular-Histone-Induced Liver Injury, Kidney Dysfunction, and Mortality in a Rat Model of Acute Hyperinflammation.	Int J Mol Sci	2024	https://conductscience.org/library/papers/38338654	PubMed
37,663,654	Mast cell-mediated immune regulation in health and disease.	Front Med (Lausanne)	2023	https://conductscience.org/library/papers/37663654	PubMed
35,514,744	Building Block Analysis of ATIII Affinity Fractions of Heparins: Application to the ATIII Binding Capacity of Non-conventional 3-O-Sulfated Sequences.	Front Med (Lausanne)	2022	https://conductscience.org/library/papers/35514744	PubMed
35,433,769	Heparinase Digestion of 3-O-Sulfated Sequences: Selective Heparinase II Digestion for Separation and Identification of Binding Sequences Present in ATIII Affinity Fractions of Bovine Intestinal Heparins.	Front Med (Lausanne)	2022	https://conductscience.org/library/papers/35433769	PubMed
30,850,987	Revisiting the Pharmacology of Unfractionated Heparin.	Clin Pharmacokinet	2019	https://conductscience.org/library/papers/30850987	PubMed
29,732,735	Tissue Engineering at the Blood-Contacting Surface: A Review of Challenges and Strategies in Vascular Graft Development.	Adv Healthc Mater	2018	https://conductscience.org/library/papers/29732735	PubMed
28,635,655	From Farm to Pharma: An Overview of Industrial Heparin Manufacturing Methods.	Molecules	2017	https://conductscience.org/library/papers/28635655	PubMed
28,282,887	New Insights in Thrombin Inhibition Structure-Activity Relationships by Characterization of Octadecasaccharides from Low Molecular Weight Heparin.	Molecules	2017	https://conductscience.org/library/papers/28282887	PubMed

1 to 10 of 62

See all 62 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
SERPINC1	462	PubTator's text mining	https://conductscience.org/library/genes/462

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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