Paper13205

Direct measurement of the intracellular pH of mammalian cardiac muscle.

Ellis D and 1 other. J Physiol, 1976. Cited by 257 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Direct measurement of the intracellular pH of mammalian cardiac muscle. Papers, record 13205. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/13205

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Direct measurement of the intracellular pH of mammalian cardiac muscle.; PubMed
Journal: J Physiol; PubMed
Year: 1976; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/13205/; PubMed
DOI: https://doi.org/10.1113/jphysiol.1976.sp011619; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC1307671/; PubMed
The journal: https://conductscience.org/library/journal-index/0266262; PubMed
Citations, by iCite: 257; iCite
Relative citation ratio, by iCite: 9.99; iCite
Revised in PubMed: 2019-05-09; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Ellis D	D
2	Thomas RC	R C

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Heart	Major topic
Heart Conduction System	Major topic
Purkinje Fibers	Major topic
Acetazolamide
Animals
Carbon Dioxide
Ferrets
Guinea Pigs
Heart Ventricles
Hydrogen-Ion Concentration
Hypertonic Solutions
In Vitro Techniques
Myocardial Contraction
Ouabain
Rats
Sheep
Ventricular Function

Source PubMed

Show 11 more topicsShow fewer topics

References17

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	156	Effect of coronary blood flow on glycolytic flux and intracellular pH in isolated rat hearts.	Circ Res	1975	https://conductscience.org/library/papers/156	PubMed
2	1,523	Micro-electrode measurement of the internal pH of crab muscle fibres.	J Physiol	1975	https://conductscience.org/library/papers/1523	PubMed
3	4,614	The effect of carbon dioxide on the intracellular pH and buffering power of snail neurones.	J Physiol	1976	https://conductscience.org/library/papers/4614	PubMed
4	6,917	Microelectrode measurement of the intracellular pH of mammalian heart cells.	Nature	1976	https://conductscience.org/library/papers/6917	PubMed
5	234,688	Effect of osmolarity on intracellular pH of rat diaphragm muscle.?22.	Am J Physiol	1975	https://conductscience.org/library/papers/234688	PubMed
6	934,324	Ionic mechanism of the H+ pump in a snail neurone.	Nature	1976	https://conductscience.org/library/papers/934324	PubMed
7	4,537,783	An imidazole alphastat hypothesis for vertebrate acid-base regulation: tissue carbon dioxide content and body temperature in bullfrogs.	Respir Physiol	1972	https://conductscience.org/library/papers/4537783	PubMed
8	4,705,145	Oscillations of intramuscular pH in perfused rat heart.	Can J Physiol Pharmacol	1973	https://conductscience.org/library/papers/4705145	PubMed
9	4,838,803	Intracellular pH of snail neurones measured with a new pH-sensitive glass mirco-electrode.	J Physiol	1974	https://conductscience.org/library/papers/4838803	PubMed
10	4,889,321	Intracellular pH.	Physiol Rev	1969	https://conductscience.org/library/papers/4889321	PubMed
11	4,973,240	Exchange of 11CO2 in arterial blood with body CO2 pools.	Respir Physiol	1968	https://conductscience.org/library/papers/4973240	PubMed
12	5,020,230	Intracellular pH electrode. Experiments on the giant squid axon.	Biochim Biophys Acta	1972	https://conductscience.org/library/papers/5020230	PubMed
13	5,039,276	Direct intracellular pH measurement in rat and crab muscle.	J Physiol	1972	https://conductscience.org/library/papers/5039276	PubMed
14	5,956,541	In vivo CO-2 buffer curves of skeletal and cardiac muscle.	Am J Physiol	1966	https://conductscience.org/library/papers/5956541	PubMed
15	6,026,098	Measurement of intracellular pH of skeletal muscle with pH-sensitive glass microelectrodes.	J Clin Invest	1967	https://conductscience.org/library/papers/6026098	PubMed
16	6,033,589	Effects of ATP on the interaction of Ca++, Mg++, and K+ with fragmented sarcoplasmic reticulum isolated from rabbit skeletal muscle.	J Gen Physiol	1967	https://conductscience.org/library/papers/6033589	PubMed
20	16,992,240	Chemosensitivity of cardiac muscle.	J Physiol	1967	https://conductscience.org/library/papers/16992240	PubMed

Show 11 more referencesShow fewer references

Cited by83

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 257 citations.

PMID	Title	Journal	Year	In Papers	Source
41,008,551	Ca2+ Signaling in Striated Muscle Cells During Intracellular Acidosis.	Biomolecules	2025	https://conductscience.org/library/papers/41008551	PubMed
39,444,753	Effects of extracellular metabolic acidosis and out-of-equilibrium CO2/HCO3 - solutions on intracellular pH in cultured rat hippocampal neurons.	Front Physiol	2024	https://conductscience.org/library/papers/39444753	PubMed
36,455,760	Management of Multisystem Inflammatory Syndrome in Children: Decision-Making Regarding a New Condition in the Absence of Clinical Trial Data.	Can J Cardiol	2023	https://conductscience.org/library/papers/36455760	PubMed
35,463,464	Protocol to record and quantify the intracellular pH in contracting cardiomyocytes.	STAR Protoc	2022	https://conductscience.org/library/papers/35463464	PubMed
35,005,560	Beat-to-beat dynamic regulation of intracellular pH in cardiomyocytes.	iScience	2022	https://conductscience.org/library/papers/35005560	PubMed
33,606,000	Filament evanescence of myosin II and smooth muscle function.	J Gen Physiol	2021	https://conductscience.org/library/papers/33606000	PubMed
24,967,717	Evaluation of the growth environment of a hydrostatic force bioreactor for preconditioning of tissue-engineered constructs.	Tissue Eng Part C Methods	2015	https://conductscience.org/library/papers/24967717	PubMed
23,728,973	Peripheral chemoreceptors: function and plasticity of the carotid body.	Compr Physiol	2012	https://conductscience.org/library/papers/23728973	PubMed
16,924,128	Expression of membrane-bound carbonic anhydrases IV, IX, and XIV in the mouse heart.	J Histochem Cytochem	2006	https://conductscience.org/library/papers/16924128	PubMed
15,194,736	Effect of extracellular acid-base disturbances on the intracellular pH of neurones cultured from rat medullary raphe or hippocampus.	J Physiol	2004	https://conductscience.org/library/papers/15194736	PubMed
10,481,214	Role of the sodium-hydrogen exchanger in ischemia-reperfusion injury in diabetes.	J Thromb Thrombolysis	1999	https://conductscience.org/library/papers/10481214	PubMed
9,575,296	Out-of-equilibrium pH transients in the guinea-pig ventricular myocyte.	J Physiol	1998	https://conductscience.org/library/papers/9575296	PubMed
9,490,828	The effects of extracellular and intracellular pH on intracellular Ca2+ regulation in guinea-pig detrusor smooth muscle.	J Physiol	1998	https://conductscience.org/library/papers/9490828	PubMed
9,163,353	Divergent effects of extracellular and intracellular alkalosis on Ca2+ entry pathways in vascular endothelial cells.	Biochem J	1997	https://conductscience.org/library/papers/9163353	PubMed
8,932,456	Ion-pairing interactions between 99MTc-based myocardial imaging agents and oleic acid.	Pharm Res	1996	https://conductscience.org/library/papers/8932456	PubMed
8,410,686	Extracellular pH signals affect rat vascular tone by rapid transduction into intracellular pH changes.	J Physiol	1993	https://conductscience.org/library/papers/8410686	PubMed
8,380,978	Characterization of the placental brush border membrane Na+/H+ exchanger: identification of thiol-dependent transitions in apparent molecular size.	Biochem J	1993	https://conductscience.org/library/papers/8380978	PubMed
8,271,193	Changes of intracellular pH in rat mesenteric vascular smooth muscle with high-K+ depolarization.	J Physiol	1993	https://conductscience.org/library/papers/8271193	PubMed
8,021,835	A comparison of the effects of intracellular and extracellular pH on contraction in isolated rat portal vein.	J Physiol	1994	https://conductscience.org/library/papers/8021835	PubMed
7,838,692	Differential effects of external pH alteration on intracellular pH in rat coronary and cardiac myocytes.	Pflugers Arch	1994	https://conductscience.org/library/papers/7838692	PubMed

Show 14 more cited byShow fewer cited bySee all 83 cited by

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

None in this release

Grants
Trials
Comments and corrections
Genes
Drugs
Data

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/13205

GET https://conductscience.org/api/papers/v1/13205/cited_by?page=2

API reference For AI assistants