Paper · 165258

Neutrophil-mediated tumor cell cytotoxicity: role of the peroxidase system.

Clark RA and 1 other. J Exp Med, 1975. Cited by 353 papers, by iCite.

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ConductScience Library. Neutrophil-mediated tumor cell cytotoxicity: role of the peroxidase system. Papers, record 165258. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/165258

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Neutrophil-mediated tumor cell cytotoxicity: role of the peroxidase system.; PubMed
Journal: J Exp Med; PubMed
Year: 1975; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/165258/; PubMed
DOI: https://doi.org/10.1084/jem.141.6.1442; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2189847/; PubMed
The journal: https://conductscience.org/library/journal-index/2985109R; PubMed
Citations, by iCite: 353; iCite
Relative citation ratio, by iCite: 7.69; iCite
Revised in PubMed: 2021-01-05; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Clark RA	R A
2	Klebanoff SJ	S J

Source PubMed

Topics22

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Neutrophils	Major topic
Peroxidase	Major topic
Peroxidases	Major topic
Animals
Azides
Catalase
Chlorides
Chromium Radioisotopes
Cyanides
Cytotoxicity Tests, Immunologic
Glucosephosphate Dehydrogenase Deficiency
Granulomatous Disease, Chronic
Humans
Hydrogen Peroxide
Iodides
Lymphoma
Male
Mice
Mice, Inbred BALB C
Opsonin Proteins
Phagocytosis
Zymosan

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References17

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	5,129,301	Oxidant injury of caucasian glucose-6-phosphate dehydrogenase-deficient red blood cells by phagocytosing leukocytes during infection.	J Clin Invest	1971	https://conductscience.org/library/papers/5129301	PubMed
2	5,522,855	A uterine fluid-mediated sperm-inhibitory system.	Biol Reprod	1970	https://conductscience.org/library/papers/5522855	PubMed
3	5,765,020	Degranulation of leukocytes in chronic granulomatous disease.	J Clin Invest	1969	https://conductscience.org/library/papers/5765020	PubMed
4	5,796,360	Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection.	J Clin Invest	1969	https://conductscience.org/library/papers/5796360	PubMed
5	1,118,738	Antimicrobial mechanisms in neutrophilic polymorphonuclear leukocytes.	Semin Hematol	1975	https://conductscience.org/library/papers/1118738	PubMed
6	1,120,184	Peroxidase-H2O2-halide system: Cytotoxic effect on mammalian tumor cells.	Blood	1975	https://conductscience.org/library/papers/1120184	PubMed
7	4,125,296	Neutrophil dysfunction, chronic granulomatous disease, and non-spherocytic haemolytic anaemia caused by complete deficiency of glucose-6-phosphate dehydrogenase.	Lancet	1973	https://conductscience.org/library/papers/4125296	PubMed
8	4,131,165	An in vitro study of exocytosis of neutrophil granule enzymes in chronic granulomatous disease neutrophils.	J Immunol	1974	https://conductscience.org/library/papers/4131165	PubMed
9	4,340,975	Leukocytic proteases and the immunologic release of lysosomal enzymes.	Am J Pathol	1972	https://conductscience.org/library/papers/4340975	PubMed
10	4,372,270	Modulation of polymorphonuclear leukocyte-mediated antibody-dependent cellular cytotoxicity.	J Immunol	1974	https://conductscience.org/library/papers/4372270	PubMed

1 to 10 of 17

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Cited by109

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 353 citations.

PMID	Title	Journal	Year	In Papers	Source
42,979,333	Targeting cancer-associated neutrophils with biomimetic nano-vaccines loaded with mRNA can enhance the efficacy of immunotherapy for hepatocellular carcinoma.	Acta Pharm Sin B	2026	https://conductscience.org/library/papers/42979333	PubMed
42,023,239	Tumor-associated neutrophils in pancreatic ductal adenocarcinoma: mechanisms and therapeutic targeting.	Front Immunol	2026	https://conductscience.org/library/papers/42023239	PubMed
41,499,552	IL10R Inhibition Induces Neutrophil Tumoricidal Activity.	Cancer Immunol Res	2026	https://conductscience.org/library/papers/41499552	PubMed
40,528,159	Targeting circulating tumor cell‒neutrophil interactions: nanoengineered strategies for inhibiting cancer metastasis.	J Nanobiotechnology	2025	https://conductscience.org/library/papers/40528159	PubMed
40,187,604	TRAIL induces cytokine production via the NFkB2 pathway promoting neutrophil chemotaxis and neutrophil-mediated immune-suppression in triple negative breast cancer cells.	Cancer Lett	2025	https://conductscience.org/library/papers/40187604	PubMed
39,941,753	Neutrophil Engulfment in Cancer: Friend or Foe?	Cancers (Basel)	2025	https://conductscience.org/library/papers/39941753	PubMed
39,814,410	NADPH oxidases: redox regulation of cell homeostasis and disease.	Physiol Rev	2025	https://conductscience.org/library/papers/39814410	PubMed
39,567,761	The diverse roles of neutrophils from protection to pathogenesis.	Nat Immunol	2024	https://conductscience.org/library/papers/39567761	PubMed
39,222,166	CD24 affects the immunosuppressive effect of tumor-infiltrating cells and tumor resistance in a variety of cancers.	Discov Oncol	2024	https://conductscience.org/library/papers/39222166	PubMed
38,846,085	β-Lapachone promotes the recruitment and polarization of tumor-associated neutrophils (TANs) toward an antitumor (N1) phenotype in NQO1-positive cancers.	Oncoimmunology	2024	https://conductscience.org/library/papers/38846085	PubMed

1 to 10 of 109

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Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
CAT	847	PubTator's text mining	https://conductscience.org/library/genes/847	NCBI Gene
MPO	4,353	PubTator's text mining	https://conductscience.org/library/genes/4353	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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