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Paper · 1662630

An open study to compare the pharmacokinetics, safety and tolerability of a multiple-dose regimen of azithromycin in young and elderly volunteers.

Coates P and 4 others. Eur J Clin Microbiol Infect Dis, 1991. Cited by 31 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. An open study to compare the pharmacokinetics, safety and tolerability of a multiple-dose regimen of azithromycin in young and elderly volunteers. Papers, record 1662630. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/1662630

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
An open study to compare the pharmacokinetics, safety and tolerability of a multiple-dose regimen of azithromycin in young and elderly volunteers.
PubMed
Journal
Eur J Clin Microbiol Infect Dis
PubMed
Year
1991
PubMed
Publication types
Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
31
iCite
Relative citation ratio, by iCite
1.56
iCite
Revised in PubMed
2019-08-27
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Coates PP
2Daniel RR
3Houston ACA C
4Antrobus JHJ H
5Taylor TT

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
ErythromycinMajor topic
Administration, Oral
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Azithromycin
Drug Administration Schedule
Drug Tolerance
Female
Humans
Male
Middle Aged

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References5

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
12,449,865Spectrum and mode of action of azithromycin (CP-62,993), a new 15-membered-ring macrolide with improved potency against gram-negative organisms.Antimicrob Agents Chemother1987https://conductscience.org/library/papers/2449865PubMed
22,154,442Relationship of high tissue concentrations of azithromycin to bactericidal activity and efficacy in vivo.J Antimicrob Chemother1990https://conductscience.org/library/papers/2154442PubMed
31,244,564Prediction of creatinine clearance from serum creatinine.Nephron1976https://conductscience.org/library/papers/1244564PubMed
42,154,441The pharmacokinetics of azithromycin in human serum and tissues.J Antimicrob Chemother1990https://conductscience.org/library/papers/2154441PubMed
52,830,841Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution.Antimicrob Agents Chemother1987https://conductscience.org/library/papers/2830841PubMed

Cited by11

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 31 citations.

PMIDTitleJournalYearIn PapersSource
40,636,323Significant Predictors of Azithromycin in Population Pharmacokinetic Analysis: A Systematic Review.Drug Des Devel Ther2025https://conductscience.org/library/papers/40636323PubMed
39,403,139An insight into pharmacokinetics and dose optimization of antimicrobials agents in elderly patients.Front Pharmacol2024https://conductscience.org/library/papers/39403139PubMed
28,429,305The Role of Macrolides in Chronic Rhinosinusitis (CRSsNP and CRSwNP).Curr Allergy Asthma Rep2017https://conductscience.org/library/papers/28429305PubMed
19,451,282Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study.Antimicrob Agents Chemother2009https://conductscience.org/library/papers/19451282PubMed
19,223,626Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers.Antimicrob Agents Chemother2009https://conductscience.org/library/papers/19223626PubMed
8,913,468Safety, toleration, and pharmacokinetics of intravenous azithromycin.Antimicrob Agents Chemother1996https://conductscience.org/library/papers/8913468PubMed
8,383,944Pharmacokinetics of azithromycin in pediatric patients after oral administration of multiple doses of suspension.Antimicrob Agents Chemother1993https://conductscience.org/library/papers/8383944PubMed
8,287,632Azithromycin clinical pharmacokinetics.Clin Pharmacokinet1993https://conductscience.org/library/papers/8287632PubMed
7,840,560In vitro and in vivo activities of azithromycin, a new azalide antibiotic, against chlamydia.Antimicrob Agents Chemother1994https://conductscience.org/library/papers/7840560PubMed
7,486,938Pharmacokinetics of azithromycin in pediatric patients with acute otitis media.Antimicrob Agents Chemother1995https://conductscience.org/library/papers/7486938PubMed

1 to 10 of 11

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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