Paper · 16670331

Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering.

Kobayashi M and 9 others. J Immunol, 2006. Cited by 137 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering. Papers, record 16670331. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/16670331

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering.; PubMed
Journal: J Immunol; PubMed
Year: 2006; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/16670331/; PubMed
DOI: https://doi.org/10.4049/jimmunol.176.10.6211; PubMed
The journal: https://conductscience.org/library/journal-index/2985117R; PubMed
Citations, by iCite: 137; iCite
Relative citation ratio, by iCite: 2.85; iCite
Revised in PubMed: 2019-05-16; PubMed

Authors10

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Kobayashi M	Makiko
2	Saitoh S	Shin-ichiroh
3	Tanimura N	Natsuko
4	Takahashi K	Koichiro
5	Kawasaki K	Kiyoshi
6	Nishijima M	Masahiro
7	Fujimoto Y	Yukari
8	Fukase K	Koichi
9	Akashi-Takamura S	Sachiko
10	Miyake K	Kensuke

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Lymphocyte Antigen 96	Major topic
Membrane Glycoproteins	Major topic
Receptor Aggregation	Major topic
Receptors, Cell Surface	Major topic
Toll-Like Receptor 4	Major topic
Amino Acid Substitution
Animals
Cell Line
Cells, Cultured
Endosomes
Hydrogen-Ion Concentration
Ligands
Mice

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by62

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 137 citations.

PMID	Title	Journal	Year	In Papers	Source
41,816,358	Gut microbiota and macrophage crosstalk: implications for colitis-associated colorectal cancer.	Front Cell Infect Microbiol	2026	https://conductscience.org/library/papers/41816358	PubMed
41,477,831	LPS-induced structural reorganization and polymerization drive noncanonical inflammasome activation.	Sci Adv	2026	https://conductscience.org/library/papers/41477831	PubMed
39,877,388	Decoding nature: multi-target anti-inflammatory mechanisms of natural products in the TLR4/NF-κB pathway.	Front Pharmacol	2024	https://conductscience.org/library/papers/39877388	PubMed
39,413,786	Multiscale drug screening for cardiac fibrosis identifies MD2 as a therapeutic target.	Cell	2024	https://conductscience.org/library/papers/39413786	PubMed
36,678,520	Therapeutic Targeting of TLR4 for Inflammation, Infection, and Cancer: A Perspective for Disaccharide Lipid A Mimetics.	Pharmaceuticals (Basel)	2022	https://conductscience.org/library/papers/36678520	PubMed
35,401,188	Anti-Inflammatory Effects of Ginsenoside Rb3 in LPS-Induced Macrophages Through Direct Inhibition of TLR4 Signaling Pathway.	Front Pharmacol	2022	https://conductscience.org/library/papers/35401188	PubMed
33,329,561	Lipopolysaccharide Recognition in the Crossroads of TLR4 and Caspase-4/11 Mediated Inflammatory Pathways.	Front Immunol	2020	https://conductscience.org/library/papers/33329561	PubMed
33,057,840	TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling.	Cell Mol Life Sci	2021	https://conductscience.org/library/papers/33057840	PubMed
32,397,494	Truncated Pneumolysin from Streptococcus pneumoniae as a TLR4-Antagonizing New Drug for Chronic Inflammatory Conditions.	Cells	2020	https://conductscience.org/library/papers/32397494	PubMed
32,378,734	Homeostatic and pathogenic roles of GM3 ganglioside molecular species in TLR4 signaling in obesity.	EMBO J	2020	https://conductscience.org/library/papers/32378734	PubMed

1 to 10 of 62

See all 62 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
TLR4	7,099	PubTator's text mining	https://conductscience.org/library/genes/7099

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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