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Paper · 16838121

Histamine mediates the stimulatory action of ghrelin on acid secretion in rat stomach.

Yakabi K and 7 others. Dig Dis Sci, 2006. Cited by 29 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Histamine mediates the stimulatory action of ghrelin on acid secretion in rat stomach. Papers, record 16838121. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/16838121

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Histamine mediates the stimulatory action of ghrelin on acid secretion in rat stomach.
PubMed
Journal
Dig Dis Sci
PubMed
Year
2006
PubMed
Publication types
Comparative Study, Journal Article
PubMed
Citations, by iCite
29
iCite
Relative citation ratio, by iCite
0.9
iCite
Revised in PubMed
2026-10-11
PubMed

Authors8

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Yakabi KKoji
2Ro SShoki
3Onouhi TTsuneko
4Tanaka TTeruyuki
5Ohno SShino
6Miura SSeiichi
7Johno YYukimi
8Takayama KKiyoshige

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Gastric AcidMajor topic
Gastric MucosaMajor topic
HistamineMajor topic
Peptide HormonesMajor topic
Animals
Famotidine
Ghrelin
Growth Hormone
Histamine H2 Antagonists
Histidine Decarboxylase
Male
RNA, Messenger
Rats
Rats, Wistar
Reverse Transcriptase Polymerase Chain Reaction
Stomach
Vagotomy

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References38

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
111,739,476Ghrelin enhances appetite and increases food intake in humans.J Clin Endocrinol Metab2001https://conductscience.org/library/papers/11739476PubMed
29,928,007The pituitary adenylate cyclase activating polypeptide type 1 receptor (PAC1-R) is expressed on gastric ECL cells: evidence by immunocytochemistry and RT-PCR.Ann N Y Acad Sci1998https://conductscience.org/library/papers/9928007PubMed
3956,391Studies on the mechanisms of food-stimulated gastric acid secretion in normal human subjects.J Clin Invest1976https://conductscience.org/library/papers/956391PubMed
412,221,195Physiology of gastric enterochromaffin-like cells.Annu Rev Physiol2003https://conductscience.org/library/papers/12221195PubMed
511,089,560Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans.Endocrinology2000https://conductscience.org/library/papers/11089560PubMed
611,089,570The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion.Endocrinology2000https://conductscience.org/library/papers/11089570PubMed
711,057,670Ghrelin induces adiposity in rodents.Nature2000https://conductscience.org/library/papers/11057670PubMed
87,517,373Acute responses of rat stomach enterochromaffinlike cells to gastrin: secretory activation and adaptation.Gastroenterology1994https://conductscience.org/library/papers/7517373PubMed
99,416,989Neurohormonal regulation of histamine and pancreastatin secretion from isolated rat stomach ECL cells.Regul Pept1997https://conductscience.org/library/papers/9416989PubMed
1011,557,520PACAP stimulates gastric acid secretion in the rat by inducing histamine release.Am J Physiol Gastrointest Liver Physiol2001https://conductscience.org/library/papers/11557520PubMed

1 to 10 of 38

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Cited by12

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 29 citations.

PMIDTitleJournalYearIn PapersSource
34,638,910Protective and Healing Effects of Ghrelin and Risk of Cancer in the Digestive System.Int J Mol Sci2021https://conductscience.org/library/papers/34638910PubMed
31,049,687Distributions and relationships of chemically defined enteroendocrine cells in the rat gastric mucosa.Cell Tissue Res2019https://conductscience.org/library/papers/31049687PubMed
30,467,709Relationships of endocrine cells to each other and to other cell types in the human gastric fundus and corpus.Cell Tissue Res2019https://conductscience.org/library/papers/30467709PubMed
29,552,623Translating Developmental Principles to Generate Human Gastric Organoids.Cell Mol Gastroenterol Hepatol2018https://conductscience.org/library/papers/29552623PubMed
26,115,342Motilin Stimulates Gastric Acid Secretion in Coordination with Ghrelin in Suncus murinus.PLoS One2015https://conductscience.org/library/papers/26115342PubMed
24,381,790Structure and physiological actions of ghrelin.Scientifica (Cairo)2013https://conductscience.org/library/papers/24381790PubMed
23,179,899The type 2 CCK/gastrin receptor antagonist YF476 acutely prevents NSAID-induced gastric ulceration while increasing iNOS expression.Naunyn Schmiedebergs Arch Pharmacol2013https://conductscience.org/library/papers/23179899PubMed
20,571,831Comparison of the actions of acylated and desacylated ghrelin on acid secretion in the rat stomach.J Gastroenterol2010https://conductscience.org/library/papers/20571831PubMed
19,701,601Circulating acylated ghrelin level decreases in accordance with the extent of atrophic gastritis.J Gastroenterol2009https://conductscience.org/library/papers/19701601PubMed
19,009,648Ghrelin and gastric acid secretion.World J Gastroenterol2008https://conductscience.org/library/papers/19009648PubMed

1 to 10 of 12

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Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
GAST2,520PubTator's text mininghttps://conductscience.org/library/genes/2520NCBI Gene
GHRL51,738PubTator's text mininghttps://conductscience.org/library/genes/51738NCBI Gene
HDC3,067PubTator's text mininghttps://conductscience.org/library/genes/3067NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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