Paper · 168490

Characterization of alpha1-antitrypsin in the inclusion bodies from the liver in alpha 1-antitrypsin deficiency.

Jeppsson JO and 2 others. N Engl J Med, 1975. Cited by 120 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Characterization of alpha1-antitrypsin in the inclusion bodies from the liver in alpha 1-antitrypsin deficiency. Papers, record 168490. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/168490

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Characterization of alpha1-antitrypsin in the inclusion bodies from the liver in alpha 1-antitrypsin deficiency.; PubMed
Journal: N Engl J Med; PubMed
Year: 1975; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/168490/; PubMed
DOI: https://doi.org/10.1056/nejm197509182931203; PubMed
The journal: https://conductscience.org/library/journal-index/0255562; PubMed
Citations, by iCite: 120; iCite
Relative citation ratio, by iCite: 3.12; iCite
Revised in PubMed: 2013-11-21; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Jeppsson JO	J O
2	Larsson C	C
3	Eriksson S	S

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Inclusion Bodies	Major topic
Liver	Major topic
alpha 1-Antitrypsin	Major topic
Amino Acid Sequence
Amino Acids
Carbohydrates
Centrifugation
Chromatography
Chromatography, Gas
Chromatography, Gel
Cyanogen Bromide
Electrophoresis, Polyacrylamide Gel
Humans
Immunodiffusion
Molecular Weight
Sialic Acids
Solubility
alpha 1-Antitrypsin Deficiency

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by31

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 120 citations.

PMID	Title	Journal	Year	In Papers	Source
41,216,612	Characterization of alpha-1 antitrypsin in a Pi∗ZZ patient with emphysema: a case report.	Respir Med Case Rep	2025	https://conductscience.org/library/papers/41216612	PubMed
40,333,971	High-resolution characterization of ex vivo AAT polymers by solution-state NMR spectroscopy.	Sci Adv	2025	https://conductscience.org/library/papers/40333971	PubMed
37,354,999	Glycosylation shapes the efficacy and safety of diverse protein, gene and cell therapies.	Biotechnol Adv	2023	https://conductscience.org/library/papers/37354999	PubMed
36,476,855	Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity.	Cell Rep	2022	https://conductscience.org/library/papers/36476855	PubMed
35,694,676	Glycosylation of HDL-Associated Proteins and Its Implications in Cardiovascular Disease Diagnosis, Metabolism and Function.	Front Cardiovasc Med	2022	https://conductscience.org/library/papers/35694676	PubMed
35,646,826	MetNC: Predicting Metabolites in vivo for Natural Compounds.	Front Chem	2022	https://conductscience.org/library/papers/35646826	PubMed
33,809,321	The Discovery of Endoplasmic Reticulum Storage Disease. The Connection between an H&E Slide and the Brain.	Int J Mol Sci	2021	https://conductscience.org/library/papers/33809321	PubMed
29,442,594	Pharmacoperones as Novel Therapeutics for Diverse Protein Conformational Diseases.	Physiol Rev	2018	https://conductscience.org/library/papers/29442594	PubMed
29,212,317	Targeted Measurements of O- and N-Glycopeptides Show That Proteins in High Density Lipoprotein Particles Are Enriched with Specific Glycosylation Compared to Plasma.	J Proteome Res	2018	https://conductscience.org/library/papers/29212317	PubMed
24,838,286	A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover.	Hum Mol Genet	2014	https://conductscience.org/library/papers/24838286	PubMed

1 to 10 of 31

See all 31 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
SERPINA1	5,265	PubTator's text mining	https://conductscience.org/library/genes/5265

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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