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Paper17119

Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells.

Haga T and 3 others. Proc Natl Acad Sci U S A, 1977. Cited by 195 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells. Papers, record 17119. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/17119

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1977
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
195
iCite
Relative citation ratio, by iCite
4.51
iCite
Revised in PubMed
2019-05-01
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Haga TT
2Ross EME M
3Anderson HJH J
4Gilman AGA G

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Adenylyl CyclasesMajor topic
Cell LineMajor topic
MutationMajor topic
Receptors, AdrenergicMajor topic
Receptors, Adrenergic, betaMajor topic
Adrenergic beta-Agonists
Animals
Bacterial Toxins
Binding, Competitive
Cyclic AMP
Fluorides
Guanosine Triphosphate
Isoproterenol
Karyotyping
Lymphoma
Mice
Prostaglandins E
Vibrio cholerae

Source PubMed

References21

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,167,861The control of adenylate cyclase by calcium in turkey erythrocyte ghosts.J Biol Chem1975https://conductscience.org/library/papers/1167861PubMed
21,254,565Beta-Adrenergic receptor interactions. Characterization of iodohydroxybenzylpindolol as a specific ligand.J Biol Chem1976https://conductscience.org/library/papers/1254565PubMed
3163,487Selection of a variant lymphoma cell deficient in adenylate cyclase.Science1975https://conductscience.org/library/papers/163487PubMed
4165,697Genetic analysis of cyclic AMP in a mammalian cell.Adv Cyclic Nucleotide Res1975https://conductscience.org/library/papers/165697PubMed
5167,036Somatic genetic analysis of cyclic AMP action: selection of unresponsive mutants.J Cell Physiol1975https://conductscience.org/library/papers/167036PubMed
6176,144Binding of (125I)iodohydroxybenzylpindolol to putative beta-adrenergic receptors of rat glioma cells and other cell clones.J Biol Chem1976https://conductscience.org/library/papers/176144PubMed
7183,249Hormone receptors and the control of cyclic AMP metabolism in parental and hybrid somatic cells.Recent Prog Horm Res1976https://conductscience.org/library/papers/183249PubMed
8187,924Beta adrenergic receptors and adenylate cyclase: products of separate genes?Mol Pharmacol1976https://conductscience.org/library/papers/187924PubMed
9190,227Expression of genes for metabolism of cyclic adenosine 3':5'-monophosphate in somatic cells. beta-Adrenergic and PGE1 receptors in parental and hybrid cells.J Biol Chem1977https://conductscience.org/library/papers/190227PubMed
10236,641Role of adenine and guanine nucleotides in the activity and response of adenylate cyclase systems to hormones: evidence for multisite transition states.Adv Cyclic Nucleotide Res1975https://conductscience.org/library/papers/236641PubMed
114,318,781A protein binding assay for adenosine 3':5'-cyclic monophosphate.Proc Natl Acad Sci U S A1970https://conductscience.org/library/papers/4318781PubMed
124,328,442The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. VI. Evidence for a role of membrane lipids.J Biol Chem1971https://conductscience.org/library/papers/4328442PubMed
134,350,647The role of acidic phospholipids in glucagon action on rat liver adenylate cyclase.J Biol Chem1973https://conductscience.org/library/papers/4350647PubMed
144,384,670Effects of lipolytic and antilipolytic substances on adenosine 3',5'-monophosphate levels in isolated fat cells.J Biol Chem1968https://conductscience.org/library/papers/4384670PubMed
154,399,634The actions of hormones on the adenyl cyclase system.Adv Biochem Psychopharmacol1970https://conductscience.org/library/papers/4399634PubMed
164,726An agonist-specific effect of guanine nucleotides on binding to the beta adrenergic receptor.Mol Pharmacol1976https://conductscience.org/library/papers/4726PubMed
174,827,395A highly sensitive adenylate cyclase assay.Anal Biochem1974https://conductscience.org/library/papers/4827395PubMed
184,830,243Uncoupling of catecholamine activation of pigeon erythrocyte membrane adenylate cyclase by filipin.J Biol Chem1974https://conductscience.org/library/papers/4830243PubMed
195,451Binding of (3H)prostaglandin E1 to putative receptors linked to adenylate cyclase of cultured cell clones.J Biol Chem1976https://conductscience.org/library/papers/5451PubMed
20785,560Regulation of adenylate cyclase coupled beta-adrenergic receptors.Recent Prog Horm Res1976https://conductscience.org/library/papers/785560PubMed

See all 21 references

Cited by30

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 195 citations.

PMIDTitleJournalYearIn PapersSource
41,158,876ARF: the most misunderstood GTPase I ever knew - why study ARF GAPs.Front Mol Biosci2025https://conductscience.org/library/papers/41158876PubMed
38,867,113Mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor.Nat Struct Mol Biol2024https://conductscience.org/library/papers/38867113PubMed
23,759,942Molecular properties of muscarinic acetylcholine receptors.Proc Jpn Acad Ser B Phys Biol Sci2013https://conductscience.org/library/papers/23759942PubMed
17,277,460Crystallization and preliminary X-ray crystallographic analysis of the receptor-uncoupled mutant of Galphai1.Acta Crystallogr Sect F Struct Biol Cryst Commun2007https://conductscience.org/library/papers/17277460PubMed
10,498,844Selective beta1-adrenoceptor blockade enhances the activity of the stimulatory G-protein in human atrial myocardium.Br J Pharmacol1999https://conductscience.org/library/papers/10498844PubMed
9,916,092Cholera toxin B subunit activates arachidonic acid metabolism.Infect Immun1999https://conductscience.org/library/papers/9916092PubMed
9,111,362Analysis of the receptor binding domain of Gpa1p, the G(alpha) subunit involved in the yeast pheromone response pathway.Mol Cell Biol1997https://conductscience.org/library/papers/9111362PubMed
6,309,151Human platelets are defective in processing of cholera toxin.Biochem J1983https://conductscience.org/library/papers/6309151PubMed
6,272,740Activation and attenuation of adenylate cyclase. The role of GTP-binding proteins as macromolecular messengers in receptor--cyclase coupling.Biochem J1981https://conductscience.org/library/papers/6272740PubMed
6,272,311Glucocorticoid-mediated inhibition of ornithine decarboxylyase activity in S49 lymphoma cells.Proc Natl Acad Sci U S A1981https://conductscience.org/library/papers/6272311PubMed
6,265,935Pseudohypoparathyroidism: inheritance of deficient receptor-cyclase coupling activity.Proc Natl Acad Sci U S A1981https://conductscience.org/library/papers/6265935PubMed
6,259,515Adenylate cyclase: the role of magnesium and other divalent cations.Mol Cell Biochem1980https://conductscience.org/library/papers/6259515PubMed
6,255,474Growth of T-lymphoma cells in serum-free medium: lack of involvement of the cyclic AMP pathway in long-term cultures.Proc Natl Acad Sci U S A1980https://conductscience.org/library/papers/6255474PubMed
6,254,021Hormone-receptor interactions are noncooperative: application to the beta-adrenergic receptor.Proc Natl Acad Sci U S A1980https://conductscience.org/library/papers/6254021PubMed
6,123,941Use of hepatocytes in primary culture for biochemical studies on liver functions.Mol Cell Biochem1982https://conductscience.org/library/papers/6123941PubMed
6,111,022The hepatic adrenergic receptors.Mol Cell Biochem1980https://conductscience.org/library/papers/6111022PubMed
6,095,039Mutants of PC12 cells with altered cyclic AMP responses.Mol Cell Biol1984https://conductscience.org/library/papers/6095039PubMed
2,982,140Genetic analysis of beta-adrenergic receptor internalization and down-regulation.Proc Natl Acad Sci U S A1985https://conductscience.org/library/papers/2982140PubMed
2,869,414Binding of agonists and antagonists to beta-adrenoceptors in rat vas deferens: relationship to functional response.Naunyn Schmiedebergs Arch Pharmacol1985https://conductscience.org/library/papers/2869414PubMed
2,848,502Techniques used in the identification and analysis of function of pertussis toxin-sensitive guanine nucleotide binding proteins.Biochem J1988https://conductscience.org/library/papers/2848502PubMed

See all 30 cited by

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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