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Paper1715315

Activation of human B cells through the CD19 surface antigen results in homotypic adhesion by LFA-1-dependent and -independent mechanisms.

Smith SH and 2 others. Immunology, 1991. Cited by 45 papers, by iCite.

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ConductScience Library. Activation of human B cells through the CD19 surface antigen results in homotypic adhesion by LFA-1-dependent and -independent mechanisms. Papers, record 1715315. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/1715315

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Activation of human B cells through the CD19 surface antigen results in homotypic adhesion by LFA-1-dependent and -independent mechanisms.
PubMed
Journal
Immunology
PubMed
Year
1991
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
45
iCite
Relative citation ratio, by iCite
0.84
iCite
Revised in PubMed
2018-11-13
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Smith SHS H
2Rigley KPK P
3Callard RER E

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antigens, CDMajor topic
Antigens, Differentiation, B-LymphocyteMajor topic
B-LymphocytesMajor topic
Lymphocyte ActivationMajor topic
Lymphocyte Function-Associated Antigen-1Major topic
Antibodies, Monoclonal
Antigens, CD19
Cell Adhesion
Cell Aggregation
Cell Line
Cells, Cultured
Humans
Palatine Tonsil

Source PubMed

References12

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
16,972,306Histocompatibility requirements for T cell help in specific in vitro antibody responses to influenza virus by human blood lymphocytes.Eur J Immunol1981https://conductscience.org/library/papers/6972306PubMed
2206,705Expression of an antigen associated with acute lymphoblastic leukemia in human leukemia-lymphoma cell lines.J Natl Cancer Inst1978https://conductscience.org/library/papers/206705PubMed
31,707,000Inhibition of B cell proliferation with anti-CD19 monoclonal antibodies: anti-CD19 antibodies do not interfere with early signaling events triggered by anti-IgM or interleukin 4.Eur J Immunol1991https://conductscience.org/library/papers/1707000PubMed
42,477,710T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1.Nature1989https://conductscience.org/library/papers/2477710PubMed
52,479,707CD19 is functionally and physically associated with surface immunoglobulin.J Exp Med1989https://conductscience.org/library/papers/2479707PubMed
62,450,350Antigen-independent regulation of cytoplasmic calcium in B cells with a 12-kDa B-cell growth factor and anti-CD19.Proc Natl Acad Sci U S A1988https://conductscience.org/library/papers/2450350PubMed
72,437,199CD19 monoclonal antibody HD37 inhibits anti-immunoglobulin-induced B cell activation and proliferation.J Immunol1987https://conductscience.org/library/papers/2437199PubMed
83,257,976Resting B lymphocytes can be triggered directly through the CDw40 (Bp50) antigen. A comparison with IL-4-mediated signaling.J Immunol1988https://conductscience.org/library/papers/3257976PubMed
93,181,139Temporal relationship between inositol polyphosphate formation and increases in cytosolic Ca2+ in quiescent 3T3 cells stimulated by platelet-derived growth factor, bombesin and vasopressin.EMBO J1988https://conductscience.org/library/papers/3181139PubMed
103,552,705LFA-1 beta-chain synthesis and degradation in patients with leukocyte-adhesive proteins deficiency.Eur J Immunol1987https://conductscience.org/library/papers/3552705PubMed
113,487,090Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50.Proc Natl Acad Sci U S A1986https://conductscience.org/library/papers/3487090PubMed
121,694,130Signaling through CD19, Fc receptors or transforming growth factor-beta: each inhibits the activation of resting human B cells differently.Eur J Immunol1990https://conductscience.org/library/papers/1694130PubMed

Cited by9

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 45 citations.

PMIDTitleJournalYearIn PapersSource
37,509,608A Dual Role of Osteopontin in Modifying B Cell Responses.Biomedicines2023https://conductscience.org/library/papers/37509608PubMed
19,454,653Pivotal advance: CEACAM1 is a negative coreceptor for the B cell receptor and promotes CD19-mediated adhesion of B cells in a PI3K-dependent manner.J Leukoc Biol2009https://conductscience.org/library/papers/19454653PubMed
11,133,022Globotriaosyl ceramide modulates interferon-alpha-induced growth inhibition and CD19 expression in Burkitt's lymphoma cells.Glycoconj J1999https://conductscience.org/library/papers/11133022PubMed
8,132,206Homotypic adhesion of rat B cells, but not T cells, in response to cross-linking of CD48.Immunology1994https://conductscience.org/library/papers/8132206PubMed
8,099,567A new CD43 monoclonal antibody induces homotypic aggregation of human leucocytes through a CD11a/CD18-dependent and -independent mechanism.Immunology1993https://conductscience.org/library/papers/8099567PubMed
7,682,536Inhibition of LFA-1-dependent human B-cell aggregation induced by CD40 antibodies and interleukin-4 leads to decreased IgE synthesis.Immunology1993https://conductscience.org/library/papers/7682536PubMed
7,595,190Engaging CD19 or target of an antiproliferative antibody 1 on human B lymphocytes induces binding of B cells to the interfollicular stroma of human tonsils via integrin alpha 4/beta 1 and fibronectin.J Exp Med1995https://conductscience.org/library/papers/7595190PubMed
7,516,406
CD19 has a potential CD77 (globotriaosyl ceramide)-binding site with sequence similarity to verotoxin B-subunits: implications of molecular mimicry for B cell adhesion and enterohemorrhagic Escherichia coli pathogenesis.
J Exp Med1994https://conductscience.org/library/papers/7516406PubMed
1,370,688Crosslinking of the T cell-specific accessory molecules CD7 and CD28 modulates T cell adhesion.J Exp Med1992https://conductscience.org/library/papers/1370688PubMed

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CD19930PubTator's text mininghttps://conductscience.org/library/genes/930NCBI Gene
ITGAL3,683PubTator's text mininghttps://conductscience.org/library/genes/3683NCBI Gene

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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