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Paper · 17510285

Autophagy suppresses tumor progression by limiting chromosomal instability.

Mathew R and 8 others. Genes Dev, 2007. Cited by 794 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Autophagy suppresses tumor progression by limiting chromosomal instability. Papers, record 17510285. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/17510285

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Autophagy suppresses tumor progression by limiting chromosomal instability.
PubMed
Journal
Genes Dev
PubMed
Year
2007
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
794
iCite
Relative citation ratio, by iCite
16
iCite
Revised in PubMed
2022-11-10
PubMed

Authors9

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Mathew RRobin
2Kongara SSameera
3Beaudoin BBrian
4Karp CMCristina M
5Bray KKevin
6Degenhardt KKurt
7Chen GGuanghua
8Jin SShengkan
9White EEileen

Source PubMed

Topics29

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AutophagyMajor topic
Chromosomal InstabilityMajor topic
Microtubule-Associated ProteinsMajor topic
NeoplasmsMajor topic
ProteinsMajor topic
Animals
Apoptosis
Apoptosis Regulatory Proteins
Aspartic Acid
Autophagy-Related Protein 5
Beclin-1
Blotting, Western
Cells, Cultured
Centrosome
Chromosome Aberrations
DNA Damage
Disease Progression
Epithelial Cells
Fluorescent Antibody Technique
Kidney
Loss of Heterozygosity
Metabolism
Mice
Mice, Knockout
Phosphonoacetic Acid
Ploidies
Proto-Oncogene Proteins c-bcl-2
Pyrimidines
Signal Transduction

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
R37 CA053370NCI NIH HHSUnited StatesR37CA053370PubMed and NIH
R37 CA53370NCI NIH HHSUnited StatesR37CA053370PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References45

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
110,691,732ATR disruption leads to chromosomal fragmentation and early embryonic lethality.Genes Dev2000https://conductscience.org/library/papers/10691732PubMed
211,099,404Autophagy as a regulated pathway of cellular degradation.Science2000https://conductscience.org/library/papers/11099404PubMed
311,266,458Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells.J Cell Biol2001https://conductscience.org/library/papers/11266458PubMed
411,504,867Suppression of gene amplification and chromosomal DNA integration by the DNA mismatch repair system.Nucleic Acids Res2001https://conductscience.org/library/papers/11504867PubMed
511,687,795Assembly of microarrays for genome-wide measurement of DNA copy number.Nat Genet2001https://conductscience.org/library/papers/11687795PubMed
611,836,241Bax and Bak independently promote cytochrome C release from mitochondria.J Biol Chem2002https://conductscience.org/library/papers/11836241PubMed
712,086,891A role for common fragile site induction in amplification of human oncogenes.Cancer Cell2002https://conductscience.org/library/papers/12086891PubMed
812,415,252Centrosome aberrations: cause or consequence of cancer progression?Nat Rev Cancer2002https://conductscience.org/library/papers/12415252PubMed
912,456,786Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair.Microbiol Mol Biol Rev2002https://conductscience.org/library/papers/12456786PubMed
1012,509,235Gamma-ray and hydrogen peroxide induction of gene amplification in hamster cells deficient in DNA double strand break repair.DNA Repair (Amst)2002https://conductscience.org/library/papers/12509235PubMed

1 to 10 of 45

See all 45 references

Cited by523

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 794 citations.

PMIDTitleJournalYearIn PapersSource
42,760,279Autophagy inhibition sensitizes radiotherapy responses in high-grade mutant IDH1 glioma.Nat Commun2026https://conductscience.org/library/papers/42760279PubMed
42,589,327Autophagy in Melanoma: Molecular Mechanisms and Therapeutic Perspectives.Int J Mol Sci2026https://conductscience.org/library/papers/42589327PubMed
42,562,573Lysosomal metabolism in pancreatic cancer and its crosstalk with host physiology.Genes Dev2026https://conductscience.org/library/papers/42562573PubMed
42,514,888Nanomedicine-Mediated Autophagy Modulation in Placental Impairment Versus Cancers: A Narrative Review.Pharmaceutics2026https://conductscience.org/library/papers/42514888PubMed
42,445,717Dual regulation of autophagy: paradoxical effects on tumor angiogenesis.Front Cell Dev Biol2026https://conductscience.org/library/papers/42445717PubMed
42,313,297An overview of circular RNAs in the regulation of autophagy in lung cancer.Discov Oncol2026https://conductscience.org/library/papers/42313297PubMed
42,257,976Targeting programmed cell death: a novel therapeutic paradigm for cancer based on mode-of-death classification.Apoptosis2026https://conductscience.org/library/papers/42257976PubMed
42,256,351Minimal N-methylated and stapled peptide inhibitors of the autophagy protein GABARAP.RSC Chem Biol2026https://conductscience.org/library/papers/42256351PubMed
42,196,188Autophagy in Ovarian Cancer, an Opportunity or an Additional Threat?Int J Mol Sci2026https://conductscience.org/library/papers/42196188PubMed
42,151,413Autophagy modulation in cancer.Nat Rev Drug Discov2026https://conductscience.org/library/papers/42151413PubMed

1 to 10 of 523

See all 523 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
BECN18,678PubTator's text mininghttps://conductscience.org/library/genes/8678

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data2

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bankAccessionSource
RefSeqAC_109608RefSeq
RefSeqNM_023525RefSeq

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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