Paper17617618

Therapeutic anti-inflammatory effects of myeloid cell adenosine receptor A2a stimulation in lipopolysaccharide-induced lung injury.

Reutershan J and 4 others. J Immunol, 2007. Cited by 107 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Therapeutic anti-inflammatory effects of myeloid cell adenosine receptor A2a stimulation in lipopolysaccharide-induced lung injury. Papers, record 17617618. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/17617618

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Therapeutic anti-inflammatory effects of myeloid cell adenosine receptor A2a stimulation in lipopolysaccharide-induced lung injury.; PubMed
Journal: J Immunol; PubMed
Year: 2007; PubMed
Publication types: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/17617618/; PubMed
DOI: https://doi.org/10.4049/jimmunol.179.2.1254; PubMed
The journal: https://conductscience.org/library/journal-index/2985117R; PubMed
Citations, by iCite: 107; iCite
Relative citation ratio, by iCite: 2.64; iCite
Revised in PubMed: 2019-05-16; PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Reutershan J	Jörg
2	Cagnina RE	Rebecca E
3	Chang D	Daniel
4	Linden J	Joel
5	Ley K	Klaus

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Chemotaxis, Leukocyte	Major topic
Lipopolysaccharides	Major topic
Lung Diseases	Major topic
Receptor, Adenosine A2A	Major topic
Animals
Capillary Permeability
Chemokines
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Immunohistochemistry
Lung
Male
Mice
Mice, Knockout
Neutrophils
RNA, Messenger
Reverse Transcriptase Polymerase Chain Reaction
Transplantation Chimera

Source PubMed

Show 12 more topicsShow fewer topics

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
T32 GM007267	NIGMS NIH HHS	United States	T32GM007267	PubMed and NIH	NIH RePORTER
HL73361	NHLBI NIH HHS	United States	P01HL073361	PubMed and NIH	NIH RePORTER

Cited by74

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 107 citations.

PMID	Title	Journal	Year	In Papers	Source
39,872,847	CD73/adenosine dynamics in treatment-induced pneumonitis: balancing efficacy with risks of adverse events in combined radio-immunotherapies.	Front Cell Dev Biol	2024	https://conductscience.org/library/papers/39872847	PubMed
39,662,078	Does Adenosine Triphosphate via Purinergic Receptor Signalling Fuel Pulmonary Fibrosis?	J Innate Immun	2025	https://conductscience.org/library/papers/39662078	PubMed
38,312,838	Hypoxia-adenosine axis as therapeutic targets for acute respiratory distress syndrome.	Front Immunol	2024	https://conductscience.org/library/papers/38312838	PubMed
37,664,715	Improved survival of SARS COV-2-infected K18-hACE2 mice treated with adenosine A2AR agonist.	Heliyon	2023	https://conductscience.org/library/papers/37664715	PubMed
36,002,086	Shufeng Jiedu capsule inhibits inflammation and apoptosis by activating A2AAR and inhibiting NF-κB to alleviate LPS-induced ALI.	J Ethnopharmacol	2022	https://conductscience.org/library/papers/36002086	PubMed
34,456,928	DAMPening COVID-19 Severity by Attenuating Danger Signals.	Front Immunol	2021	https://conductscience.org/library/papers/34456928	PubMed
33,574,762	Role of Cardiac A2A Receptors Under Normal and Pathophysiological Conditions.	Front Pharmacol	2020	https://conductscience.org/library/papers/33574762	PubMed
33,567,540	Hyperhomocysteinemia and Cardiovascular Disease: Is the Adenosinergic System the Missing Link?	Int J Mol Sci	2021	https://conductscience.org/library/papers/33567540	PubMed
33,519,814	Adenosine at the Interphase of Hypoxia and Inflammation in Lung Injury.	Front Immunol	2020	https://conductscience.org/library/papers/33519814	PubMed
33,336,290	Comparison of direct and indirect models of early induced acute lung injury.	Intensive Care Med Exp	2020	https://conductscience.org/library/papers/33336290	PubMed
32,967,358	Can Adenosine Fight COVID-19 Acute Respiratory Distress Syndrome?	J Clin Med	2020	https://conductscience.org/library/papers/32967358	PubMed
32,410,853	Systemic Administration of Calea pinnatifida Inhibits Inflammation Induced by Carrageenan in a Murine Model of Pulmonary Neutrophilia.	Mediators Inflamm	2020	https://conductscience.org/library/papers/32410853	PubMed
32,210,974	Inhibition of CXCR4 and CXCR7 Is Protective in Acute Peritoneal Inflammation.	Front Immunol	2020	https://conductscience.org/library/papers/32210974	PubMed
30,093,975	Extracellular ATP is a danger signal activating P2X7 receptor in a LPS mediated inflammation (ARDS/ALI).	Oncotarget	2018	https://conductscience.org/library/papers/30093975	PubMed
29,545,806	Purinergic Regulation of Neutrophil Function.	Front Immunol	2018	https://conductscience.org/library/papers/29545806	PubMed
29,326,725	Anti-inflammatory Effects of Heme Oxygenase-1 Depend on Adenosine A2A- and A2B-Receptor Signaling in Acute Pulmonary Inflammation.	Front Immunol	2017	https://conductscience.org/library/papers/29326725	PubMed
28,798,196	The hypoxia-adenosine link during inflammation.	J Appl Physiol (1985)	2017	https://conductscience.org/library/papers/28798196	PubMed
27,696,085	Transcriptomic effects of adenosine 2A receptor deletion in healthy and endotoxemic murine myocardium.	Purinergic Signal	2017	https://conductscience.org/library/papers/27696085	PubMed
27,347,328	Pentoxifylline inhibits pulmonary inflammation induced by infrarenal aorticcross-clamping dependent of adenosine receptor A2A.	Am J Transl Res	2016	https://conductscience.org/library/papers/27347328	PubMed
27,016,586	Adenosine influences myeloid cells to inhibit aeroallergen sensitization.	Am J Physiol Lung Cell Mol Physiol	2016	https://conductscience.org/library/papers/27016586	PubMed

Show 14 more cited byShow fewer cited bySee all 74 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
ADORA2A	135	PubTator's text mining	https://conductscience.org/library/genes/135

Source NCBI Gene

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

None in this release

Trials
Comments and corrections
References
Drugs
Data

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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