Paper · 17848629

GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet.

McClean PL and 5 others. Am J Physiol Endocrinol Metab, 2007. Cited by 214 papers, by iCite.

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ConductScience Library. GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet. Papers, record 17848629. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/17848629

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet.; PubMed
Journal: Am J Physiol Endocrinol Metab; PubMed
Year: 2007; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/17848629/; PubMed
DOI: https://doi.org/10.1152/ajpendo.00460.2007; PubMed
The journal: https://conductscience.org/library/journal-index/100901226; PubMed
Citations, by iCite: 214; iCite
Relative citation ratio, by iCite: 5.16; iCite
Revised in PubMed: 2022-03-16; PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	McClean PL	Paula L
2	Irwin N	Nigel
3	Cassidy RS	Roslyn S
4	Holst JJ	Jens J
5	Gault VA	Victor A
6	Flatt PR	Peter R

Source PubMed

Topics25

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Gastric Inhibitory Polypeptide	Major topic
Insulin Resistance	Major topic
Obesity	Major topic
Receptors, Gastrointestinal Hormone	Major topic
Adipokines
Adipose Tissue
Animals
Anti-Obesity Agents
Blood Glucose
Body Weight
Corticosterone
Dietary Fats
Eating
Glucagon
Glucagon-Like Peptide 1
Glucose Intolerance
Incretins
Insulin
Lipids
Liver
Male
Mice
Motor Activity
Muscle, Skeletal
Pancreas

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by96

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 214 citations.

PMID	Title	Journal	Year	In Papers	Source
42,683,151	Tirzepatide for obesity without diabetes: mechanistic insights, clinical evidence, and future directions.	Front Pharmacol	2026	https://conductscience.org/library/papers/42683151	PubMed
42,592,044	Design and therapeutic rationale of antibody-peptide conjugates: insights from maridebart cafraglutide (AMG133) and emerging applications.	Antib Ther	2026	https://conductscience.org/library/papers/42592044	PubMed
42,240,123	Recent developments in GPCR signalling in appetite regulation.	Biosci Rep	2026	https://conductscience.org/library/papers/42240123	PubMed
41,679,433	GIPR signaling modulates PYY-induced hypophagia and malaise in rodents.	Mol Metab	2026	https://conductscience.org/library/papers/41679433	PubMed
40,806,228	Associations of Serum GIP, GLP-1, and DPP-4 with Metabolic and Hormonal Profiles and Tobacco Exposure in Women with Polycystic Ovary Syndrome.	Int J Mol Sci	2025	https://conductscience.org/library/papers/40806228	PubMed
40,347,281	Impact of chronic consumption of probiotics, oats, and apples on expression of genes related to bile acids, lipid, gut peptides, and inflammation in peripheral monocular cells - findings from the CABALA study.	Eur J Nutr	2025	https://conductscience.org/library/papers/40347281	PubMed
40,214,973	Hormonal predictors of the insulin sensitive phenotype in humans.	Biomol Biomed	2025	https://conductscience.org/library/papers/40214973	PubMed
40,201,698	The C-terminal regions of the GLP-1 and GIP receptors are not the key determinants of their differential arrestin recruitment but modulate the rate of receptor endocytosis.	Front Pharmacol	2025	https://conductscience.org/library/papers/40201698	PubMed
40,175,127	Physiology and clinical applications of GIP.	Endocr J	2025	https://conductscience.org/library/papers/40175127	PubMed
40,166,681	The role of GIPR in food intake control.	Front Endocrinol (Lausanne)	2025	https://conductscience.org/library/papers/40166681	PubMed

1 to 10 of 96

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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