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Paper · 40201698

The C-terminal regions of the GLP-1 and GIP receptors are not the key determinants of their differential arrestin recruitment but modulate the rate of receptor endocytosis.

Al-Zaid B and 1 other. Front Pharmacol, 2025. Cited by 1 paper, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The C-terminal regions of the GLP-1 and GIP receptors are not the key determinants of their differential arrestin recruitment but modulate the rate of receptor endocytosis. Papers, record 40201698. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/40201698

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The C-terminal regions of the GLP-1 and GIP receptors are not the key determinants of their differential arrestin recruitment but modulate the rate of receptor endocytosis.
PubMed
Journal
Front Pharmacol
PubMed
Year
2025
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
1
iCite
Revised in PubMed
2025-04-10
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Al-Zaid BBashaier
2Al-Sabah SSuleiman

Source PubMed

Topics0

NLM's MeSH indexing of the paper, its major topics first.

None in this release.

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References61

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
129,378,179Human GIP(3-30)NH2 inhibits G protein-dependent as well as G protein-independent signaling and is selective for the GIP receptor with high-affinity binding to primate but not rodent GIP receptors.Biochem Pharmacol2018https://conductscience.org/library/papers/29378179PubMed
233,068,776GLP-1 receptor agonists in the treatment of type 2 diabetes - state-of-the-art.Mol Metab2021https://conductscience.org/library/papers/33068776PubMed
311,171,937Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.Pharmacol Rev2001https://conductscience.org/library/papers/11171937PubMed
427,630,114Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes.Pharmacol Rev2016https://conductscience.org/library/papers/27630114PubMed
525,179,575Selectivity of peptide ligands for the human incretin receptors expressed in HEK-293 cells.Eur J Pharmacol2014https://conductscience.org/library/papers/25179575PubMed
638,316,982A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings.Nat Metab2024https://conductscience.org/library/papers/38316982PubMed
711,116,211Characterization of glucagon-like peptide-1 receptor-binding determinants.J Mol Endocrinol2000https://conductscience.org/library/papers/11116211PubMed
826,116,235Distinct regions in the C-Terminus required for GLP-1R cell surface expression, activity and internalisation.Mol Cell Endocrinol2015https://conductscience.org/library/papers/26116235PubMed
912,068,290Inhibition of gastric inhibitory polypeptide signaling prevents obesity.Nat Med2002https://conductscience.org/library/papers/12068290PubMed
1018,445,652Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cells.Proc Natl Acad Sci U S A2008https://conductscience.org/library/papers/18445652PubMed

1 to 10 of 61

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Cited by0

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1 citation.

None in this release.

Genes5

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
GCG2,641PubTator's text mininghttps://conductscience.org/library/genes/2641NCBI Gene
GIP2,695PubTator's text mininghttps://conductscience.org/library/genes/2695NCBI Gene
GIPR2,696PubTator's text mininghttps://conductscience.org/library/genes/2696NCBI Gene
GLP1R2,740PubTator's text mininghttps://conductscience.org/library/genes/2740NCBI Gene
INS3,630PubTator's text mininghttps://conductscience.org/library/genes/3630NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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