Paper · 18445652

Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cells.

Sonoda N and 5 others. Proc Natl Acad Sci U S A, 2008. Cited by 195 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cells. Papers, record 18445652. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/18445652

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cells.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 2008; PubMed
Publication types: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/18445652/; PubMed
DOI: https://doi.org/10.1073/pnas.0710402105; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2373360/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 195; iCite
Relative citation ratio, by iCite: 4.46; iCite
Revised in PubMed: 2021-10-20; PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Sonoda N	Noriyuki
2	Imamura T	Takeshi
3	Yoshizaki T	Takeshi
4	Babendure JL	Jennie L
5	Lu JC	Juu-Chin
6	Olefsky JM	Jerrold M

Source PubMed

Topics19

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Arrestins	Major topic
Glucagon-Like Peptide 1	Major topic
Insulin	Major topic
Insulin-Secreting Cells	Major topic
Signal Transduction	Major topic
Animals
Cells, Cultured
Cyclic AMP
Endocytosis
Glucagon-Like Peptide-1 Receptor
Insulin Receptor Substrate Proteins
Insulin Secretion
Intracellular Signaling Peptides and Proteins
Phosphoproteins
Protein Binding
Rats
Receptors, Glucagon
beta-Arrestin 1
beta-Arrestins

Source PubMed

Grants7

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
P01 DK074868	NIDDK NIH HHS	United States	P01DK074868	PubMed and NIH	NIH RePORTER
DK 033651	NIDDK NIH HHS	United States	R01DK033651	PubMed and NIH	NIH RePORTER
R01 DK033651	NIDDK NIH HHS	United States	R01DK033651	PubMed and NIH	NIH RePORTER
DK 074868	NIDDK NIH HHS	United States	P01DK074868	PubMed and NIH	NIH RePORTER
U54 HD012303	NICHD NIH HHS	United States	U54HD012303	PubMed and NIH	NIH RePORTER
R37 DK033651	NIDDK NIH HHS	United States	R01DK033651	PubMed and NIH	NIH RePORTER
			R37DK033651	NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References37

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	17,289,847	A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release.	Endocrinology	2007	https://conductscience.org/library/papers/17289847	PubMed
2	15,699,045	Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes.	J Biol Chem	2005	https://conductscience.org/library/papers/15699045	PubMed
3	11,598,134	Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion.	J Biol Chem	2001	https://conductscience.org/library/papers/11598134	PubMed
4	10,559,259	Endothelin-1-induced GLUT4 translocation is mediated via Galpha(q/11) protein and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes.	J Biol Chem	1999	https://conductscience.org/library/papers/10559259	PubMed
5	17,306,374	Mechanisms of action of glucagon-like peptide 1 in the pancreas.	Pharmacol Ther	2007	https://conductscience.org/library/papers/17306374	PubMed
6	16,325,578	A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription.	Cell	2005	https://conductscience.org/library/papers/16325578	PubMed
7	17,305,471	Beta-arrestins and cell signaling.	Annu Rev Physiol	2007	https://conductscience.org/library/papers/17305471	PubMed
8	12,842,910	cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.	Genes Dev	2003	https://conductscience.org/library/papers/12842910	PubMed
9	15,456,867	beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.	Mol Cell Biol	2004	https://conductscience.org/library/papers/15456867	PubMed
10	14,693,691	Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell.	Diabetes	2004	https://conductscience.org/library/papers/14693691	PubMed

1 to 10 of 37

See all 37 references

Cited by132

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 195 citations.

PMID	Title	Journal	Year	In Papers	Source
42,947,790	Insights from multi-omics on GLP-1 receptor agonists in type 2 diabetes and obesity.	Front Pharmacol	2026	https://conductscience.org/library/papers/42947790	PubMed
42,830,469	Glucagon-Like Peptide-1 Agonists and Blood Pressure Regulation: Molecular Mechanisms and Cardiovascular Implications.	Pharmacol Res Perspect	2026	https://conductscience.org/library/papers/42830469	PubMed
42,651,699	For Weight Loss: Why Do GLP-1 Agonists Work, and How Can We Make Them Work Better?	Biology (Basel)	2026	https://conductscience.org/library/papers/42651699	PubMed
42,487,666	Personalization of incretin therapy: can GLP-1 and GIP receptor polymorphisms influence therapy response?	J Endocr Soc	2026	https://conductscience.org/library/papers/42487666	PubMed
42,198,465	Multidimensional Predictors of Tirzepatide Efficacy: Clinical, Genetic, and Molecular Biomarkers for Glycemic, Weight, and Organ Protection.	Pharmaceuticals (Basel)	2026	https://conductscience.org/library/papers/42198465	PubMed
42,157,346	Progressive loss of glycemic control during chronic DPP-4 inhibitor therapy despite preserved β-cell function: a case report suggesting acquired incretin resistance.	Cardiovasc Diabetol Endocrinol Rep	2026	https://conductscience.org/library/papers/42157346	PubMed
42,106,160	Dietary Fiber and Glucagon-Like Peptide-1 Receptor Agonists in Obesity Management: Converging Mechanisms, Interactions, and Strategies for Durable Weight Control.	Adv Nutr	2026	https://conductscience.org/library/papers/42106160	PubMed
41,762,282	Unravelling the novel insights between miR-7 and Parkinson's disease (PD).	Neurol Sci	2026	https://conductscience.org/library/papers/41762282	PubMed
41,735,212	Efficacy of Dual Glucagon and GLP-1 Agonists as New Treatments for Type II Diabetes.	Mini Rev Med Chem	2026	https://conductscience.org/library/papers/41735212	PubMed
41,570,980	Modelling G protein-biased agonism using GLP-1 receptor C-terminal mutations.	Mol Metab	2026	https://conductscience.org/library/papers/41570980	PubMed

1 to 10 of 132

See all 132 cited by

Genes4

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
ARRB1	408	PubTator's text mining	https://conductscience.org/library/genes/408	NCBI Gene
ARRB2	409	PubTator's text mining	https://conductscience.org/library/genes/409	NCBI Gene
GCG	2,641	PubTator's text mining	https://conductscience.org/library/genes/2641	NCBI Gene
GLP1R	2,740	PubTator's text mining	https://conductscience.org/library/genes/2740	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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