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Paper · 185609

Thyroid hormone stimulates de novo growth hormone synthesis in cultured GH1 cells: evidence for the accumulation of a rate limiting RNA species in the induction process.

Samuels HH and 1 other. Proc Natl Acad Sci U S A, 1976. Cited by 156 papers, by iCite.

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ConductScience Library. Thyroid hormone stimulates de novo growth hormone synthesis in cultured GH1 cells: evidence for the accumulation of a rate limiting RNA species in the induction process. Papers, record 185609. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/185609

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Thyroid hormone stimulates de novo growth hormone synthesis in cultured GH1 cells: evidence for the accumulation of a rate limiting RNA species in the induction process.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1976
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
156
iCite
Relative citation ratio, by iCite
4.5
iCite
Revised in PubMed
2019-05-01
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Samuels HHH H
2Shapiro LEL E

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Growth HormoneMajor topic
Pituitary GlandMajor topic
RNAMajor topic
Receptors, Cell SurfaceMajor topic
TriiodothyronineMajor topic
Cell Line
Cell Nucleus
Cycloheximide
Dactinomycin
Deoxyadenosines
Electrophoresis, Polyacrylamide Gel
Kinetics
Protein Biosynthesis

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References20

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
111,344,581Thyroid hormone action. Demonstration of similar receptors in isolated nuclei of rat liver and cultured GH1 cells.J Clin Invest1974https://conductscience.org/library/papers/11344581PubMed
25,432,063Cleavage of structural proteins during the assembly of the head of bacteriophage T4.Nature1970https://conductscience.org/library/papers/5432063PubMed
313,672,137The effect of alterations in thyroid function on the pituitary growth hormone content and acidophil cytology.Endocrinology1959https://conductscience.org/library/papers/13672137PubMed
4169,242Binding of selected iodothyronine analogues to receptor sites of isolated rat hepatic nuclei. High correlation between structural requirements for nuclear binding and biological activity.J Biol Chem1975https://conductscience.org/library/papers/169242PubMed
5236,310Thyroid hormone receptors. Binding characteristics and lack of hormonal dependency for nuclear localization.J Biol Chem1975https://conductscience.org/library/papers/236310PubMed
64,199,418Thyroid hormone inhibition of the prolactin response to thyrotropin-releasing hormone.J Clin Invest1973https://conductscience.org/library/papers/4199418PubMed
74,335,193Estrogen action in vitro. Induction of the synthesis of a specific uterine protein.J Biol Chem1972https://conductscience.org/library/papers/4335193PubMed
84,357,872Thyroid hormone action in cell culture: domonstration of nuclear receptors in intact cells and isolated nuclei.Proc Natl Acad Sci U S A1973https://conductscience.org/library/papers/4357872PubMed
94,366,394In vitro triiodothyronine binding to non-histone proteins from rat liver nuclei.Biochem Biophys Res Commun1974https://conductscience.org/library/papers/4366394PubMed
104,372,251Thyroid hormone action: in vitro characterization of solubilized nuclear receptors from rat liver and cultured GH1 cells.J Clin Invest1974https://conductscience.org/library/papers/4372251PubMed

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Cited by22

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 156 citations.

PMIDTitleJournalYearIn PapersSource
21,760,978Thyroid hormone receptor mutations in cancer and resistance to thyroid hormone: perspective and prognosis.J Thyroid Res2011https://conductscience.org/library/papers/21760978PubMed
8,441,408Ligand-dependent, Pit-1/growth hormone factor-1 (GHF-1)-independent transcriptional stimulation of rat growth hormone gene expression by thyroid hormone receptors in vitro.Mol Cell Biol1993https://conductscience.org/library/papers/8441408PubMed
7,651,389Ligand-dependent and -independent transactivation by thyroid hormone receptor beta 2 is determined by the structure of the hormone response element.Mol Cell Biol1995https://conductscience.org/library/papers/7651389PubMed
7,399,546Evaluation of growth hormone production from GH1 cells in vitro: effect of culture media and time in culture.In Vitro1980https://conductscience.org/library/papers/7399546PubMed
7,110,131Prolactin-deficient variants of GH3 rat pituitary tumor cells: linked expression of prolactin and another hormonally responsive protein in GH3 cells.Mol Cell Biol1982https://conductscience.org/library/papers/7110131PubMed
6,945,592Two-dimensional gel analysis of rat liver nuclear proteins after thyroidectomy and thyroid hormone treatment.Proc Natl Acad Sci U S A1981https://conductscience.org/library/papers/6945592PubMed
6,820,653Establishment of functional human pituitary tumor cell cultures.In Vitro1982https://conductscience.org/library/papers/6820653PubMed
6,296,844Glucocorticoid and thyroid hormones transcriptionally regulate growth hormone gene expression.Proc Natl Acad Sci U S A1982https://conductscience.org/library/papers/6296844PubMed
6,286,750The mouse submaxillary gland: a model for the study of hormonally dependent growth factors.J Endocrinol Invest1982https://conductscience.org/library/papers/6286750PubMed
3,280,604Regulation of gene expression by thyroid hormone.J Clin Invest1988https://conductscience.org/library/papers/3280604PubMed

1 to 10 of 22

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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