Paper · 1908563

Co-engagement of CD8 with the T cell receptor is required for negative selection.

Ingold AL and 4 others. Nature, 1991. Cited by 83 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Co-engagement of CD8 with the T cell receptor is required for negative selection. Papers, record 1908563. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/1908563

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Co-engagement of CD8 with the T cell receptor is required for negative selection.; PubMed
Journal: Nature; PubMed
Year: 1991; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/1908563/; PubMed
DOI: https://doi.org/10.1038/352721a0; PubMed
The journal: https://conductscience.org/library/journal-index/0410462; PubMed
Citations, by iCite: 83; iCite
Relative citation ratio, by iCite: 1.22; iCite
Revised in PubMed: 2017-11-16; PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Ingold AL	A L
2	Landel C	C
3	Knall C	C
4	Evans GA	G A
5	Potter TA	T A

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Antigens, Differentiation, T-Lymphocyte	Major topic
Receptors, Antigen, T-Cell	Major topic
T-Lymphocytes, Cytotoxic	Major topic
Thymus Gland	Major topic
Animals
CD8 Antigens
Cell Survival
Histocompatibility Antigens Class I
Immune Tolerance
Major Histocompatibility Complex
Mice
Mice, Transgenic
Receptor Aggregation
Signal Transduction

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by17

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 83 citations.

PMID	Title	Journal	Year	In Papers	Source
23,853,580	Rapid perturbation in viremia levels drives increases in functional avidity of HIV-specific CD8 T cells.	PLoS Pathog	2013	https://conductscience.org/library/papers/23853580	PubMed
17,938,233	A constant affinity threshold for T cell tolerance.	J Exp Med	2007	https://conductscience.org/library/papers/17938233	PubMed
11,999,166	The role of CD4 in regulating homeostasis of T helper cells.	Immunol Res	2002	https://conductscience.org/library/papers/11999166	PubMed
9,539,765	Disruption of the CD4-major histocompatibility complex class II interaction blocks the development of CD4(+) T cells in vivo.	Proc Natl Acad Sci U S A	1998	https://conductscience.org/library/papers/9539765	PubMed
9,497,484	CD4 regulates the efficiency of an endogenous superantigen-induced clonal deletion of TCRV beta 11+ cells in the periphery.	Immunology	1997	https://conductscience.org/library/papers/9497484	PubMed
9,091,576	Peptide-independent recognition by alloreactive cytotoxic T lymphocytes (CTL).	J Exp Med	1997	https://conductscience.org/library/papers/9091576	PubMed
8,920,852	Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage.	J Exp Med	1996	https://conductscience.org/library/papers/8920852	PubMed
8,467,804	Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.	EMBO J	1993	https://conductscience.org/library/papers/8467804	PubMed
8,413,295	Identification and characterization of an Alu-containing, T-cell-specific enhancer located in the last intron of the human CD8 alpha gene.	Mol Cell Biol	1993	https://conductscience.org/library/papers/8413295	PubMed
8,355,705	A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines.	Mol Cell Biol	1993	https://conductscience.org/library/papers/8355705	PubMed

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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