Paper · 8355705

A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines.

Sawada S and 1 other. Mol Cell Biol, 1993. Cited by 148 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines. Papers, record 8355705. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8355705

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines.; PubMed
Journal: Mol Cell Biol; PubMed
Year: 1993; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/8355705/; PubMed
DOI: https://doi.org/10.1128/mcb.13.9.5620-5628.1993; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC360288/; PubMed
The journal: https://conductscience.org/library/journal-index/8109087; PubMed
Citations, by iCite: 148; iCite
Relative citation ratio, by iCite: 2.21; iCite
Revised in PubMed: 2026-01-28; PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Sawada S	S
2	Littman DR	D R

Source PubMed

Topics20

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
CD4 Antigens	Major topic
DNA-Binding Proteins	Major topic
T-Lymphocytes	Major topic
Transcription Factors	Major topic
Amino Acid Sequence
Animals
Base Sequence
Basic Helix-Loop-Helix Proteins
Binding Sites
Binding, Competitive
Cell Line
Enhancer Elements, Genetic
Gene Expression Regulation
Mice
Molecular Sequence Data
Nuclear Proteins
Oligodeoxyribonucleotides
Point Mutation
TCF Transcription Factors
Transcription Factor 7-Like 1 Protein

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
AI 23513	NIAID NIH HHS	United States	R01AI023513	PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References61

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	1,671,341	Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells.	Cell	1991	https://conductscience.org/library/papers/1671341	PubMed
2	1,574,119	Identification of a CD4 binding site on the beta 2 domain of HLA-DR molecules.	Nature	1992	https://conductscience.org/library/papers/1574119	PubMed
3	1,317,057	Acquisition of myogenic specificity by replacement of three amino acid residues from MyoD into E12.	Science	1992	https://conductscience.org/library/papers/1317057	PubMed
4	2,109,837	A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2.	Nature	1990	https://conductscience.org/library/papers/2109837	PubMed
5	1,555,239	The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures.	Cell	1992	https://conductscience.org/library/papers/1555239	PubMed
6	1,652,099	Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the alpha 3 domain of MHC I molecules.	Nature	1991	https://conductscience.org/library/papers/1652099	PubMed
7	1,908,563	Co-engagement of CD8 with the T cell receptor is required for negative selection.	Nature	1991	https://conductscience.org/library/papers/1908563	PubMed
8	1,673,361	CD8 is needed for development of cytotoxic T cells but not helper T cells.	Cell	1991	https://conductscience.org/library/papers/1673361	PubMed
9	2,107,025	Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs.	Cell	1990	https://conductscience.org/library/papers/2107025	PubMed
10	2,503,252	Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence.	Cell	1989	https://conductscience.org/library/papers/2503252	PubMed

1 to 10 of 61

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Cited by75

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 148 citations.

PMID	Title	Journal	Year	In Papers	Source
40,004,553	Chromatin Remodulator CHD4: A Potential Target for Cancer Interception.	Genes (Basel)	2025	https://conductscience.org/library/papers/40004553	PubMed
36,202,870	Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-β selection thymocytes.	Nat Commun	2022	https://conductscience.org/library/papers/36202870	PubMed
35,634,342	Helix-Loop-Helix Proteins in Adaptive Immune Development.	Front Immunol	2022	https://conductscience.org/library/papers/35634342	PubMed
35,049,366	The Role and Research Progress of Inhibitor of Differentiation 1 in Atherosclerosis.	DNA Cell Biol	2022	https://conductscience.org/library/papers/35049366	PubMed
34,513,839	Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease.	Front Cell Dev Biol	2021	https://conductscience.org/library/papers/34513839	PubMed
33,644,866	Epigenetic regulation of T cell adaptive immunity.	Immunol Rev	2021	https://conductscience.org/library/papers/33644866	PubMed
32,620,954	TCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci.	Hum Mol Genet	2020	https://conductscience.org/library/papers/32620954	PubMed
28,382,035	Heritable Gene Regulation in the CD4:CD8 T Cell Lineage Choice.	Front Immunol	2017	https://conductscience.org/library/papers/28382035	PubMed
27,284,104	Isolated Pancreatic Aplasia Due to a Hypomorphic PTF1A Mutation.	Diabetes	2016	https://conductscience.org/library/papers/27284104	PubMed
27,260,768	What Happens in the Thymus Does Not Stay in the Thymus: How T Cells Recycle the CD4+-CD8+ Lineage Commitment Transcriptional Circuitry To Control Their Function.	J Immunol	2016	https://conductscience.org/library/papers/27260768	PubMed

1 to 10 of 75

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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