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Paper · 1978757

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.

Malkin D and 9 others. Science, 1990. Cited by 3,192 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Papers, record 1978757. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/1978757

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.
PubMed
Journal
Science
PubMed
Year
1990
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
3,192
iCite
Relative citation ratio, by iCite
69
iCite
Revised in PubMed
2022-03-15
PubMed

Authors10

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Malkin DD
2Li FPF P
3Strong LCL C
4Fraumeni JF JrJ F
5Nelson CEC E
6Kim DHD H
7Kassel JJ
8Gryka MAM A
9Bischoff FZF Z
10Tainsky MAM A

Source PubMed

Topics21

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Breast NeoplasmsMajor topic
Genes, p53Major topic
MutationMajor topic
Neoplastic Syndromes, HereditaryMajor topic
SarcomaMajor topic
Amino Acid Sequence
Base Sequence
Chromosomes, Human, Pair 17
Cloning, Molecular
Codon
DNA
Deoxyribonucleases, Type II Site-Specific
Genetic Testing
Germ Cells
Humans
Molecular Sequence Data
Pedigree
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Repetitive Sequences, Nucleic Acid
Tumor Suppressor Protein p53

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
34936PHS HHSUnited StatesPubMedPubMed
5-T32-CA09299NCI NIH HHSUnited StatesT32CA009299PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections2

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn PapersSource
Erratum in8,438,145Correction: a Li-Fraumeni syndrome p53 mutation.https://conductscience.org/library/papers/8438145PubMed
Comment in2,244,208Genetic defect identified in rare cancer syndrome.https://conductscience.org/library/papers/2244208PubMed

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by1,069

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 3,192 citations.

PMIDTitleJournalYearIn PapersSource
42,958,579Genetic Testing Station Provides Increased Access to Germline Genetic Testing for Pediatric Oncology Patients.J Genet Couns2026https://conductscience.org/library/papers/42958579PubMed
42,928,139Characterisation of a novel p53 mutation (p53N263Tfs*7) associated with li-fraumeni syndrome.BMC Cancer2026https://conductscience.org/library/papers/42928139PubMed
42,856,358PWK genetic background reprograms heterochromatin and malignant epithelial states in Neu-driven mammary tumors.bioRxiv2026https://conductscience.org/library/papers/42856358PubMed
42,795,789Osteosarcoma Across the Age Spectrum: Why Outcomes Diverge and Trials Must Adapt.J Clin Med2026https://conductscience.org/library/papers/42795789PubMed
42,711,531Advances and Hurdles of PLGA-Based Therapy for Pancreatic Cancer.AAPS PharmSciTech2026https://conductscience.org/library/papers/42711531PubMed
42,484,901Clinical and surveillance outcomes of the TP53 c.1000G > C (p.Gly334Arg) variant.Fam Cancer2026https://conductscience.org/library/papers/42484901PubMed
42,283,896Homozygous TP53 alterations: a case of a biallelic splice variant and a brief review of the literature.Fam Cancer2026https://conductscience.org/library/papers/42283896PubMed
42,275,193Women's health across the reproductive lifespan in women with germline TP53 pathogenic variants: a clinical perspective.Oncologist2026https://conductscience.org/library/papers/42275193PubMed
42,180,127Mosaic TP53 pathogenic variant in early-onset breast cancer: a case report.Front Oncol2026https://conductscience.org/library/papers/42180127PubMed
42,149,089Variation at the R181 Residue of p53 Confers Loss of p53 DNA Binding Cooperativity with the Retention of Mitochondria-Associated Apoptosis.Mol Cancer Res2026https://conductscience.org/library/papers/42149089PubMed

1 to 10 of 1,069

See all 1,069 cited by

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
TP537,157Swiss-Prot's referenceshttps://conductscience.org/library/genes/7157

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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