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Paper · 20007326

The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways.

Houtkooper RH and 3 others. Endocr Rev, 2010. Cited by 743 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Papers, record 20007326. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/20007326

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways.
PubMed
Journal
Endocr Rev
PubMed
Year
2010
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review
PubMed
Citations, by iCite
743
iCite
Relative citation ratio, by iCite
18
iCite
Revised in PubMed
2025-05-29
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Houtkooper RHRiekelt H
2Cantó CCarles
3Wanders RJRonald J
4Auwerx JJohan

Source PubMed

Topics7

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Metabolic DiseasesMajor topic
NADMajor topic
Animals
Humans
Oxidoreductases
Signal Transduction
Transcription, Genetic

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
231138European Research CouncilInternationalPubMedPubMed
P01 DK059820NIDDK NIH HHSUnited StatesP01DK059820PubMed and NIHNIH RePORTER
DK59820NIDDK NIH HHSUnited StatesP01DK059820PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References239

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
110,455,009Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions.Biochem J1999https://conductscience.org/library/papers/10455009PubMed
216,574,057The simultaneous measurement of nicotinamide adenine dinucleotide and related compounds by liquid chromatography/electrospray ionization tandem mass spectrometry.Anal Biochem2006https://conductscience.org/library/papers/16574057PubMed
318,046,409Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.Nature2007https://conductscience.org/library/papers/18046409PubMed
410,809,662Sir2 links chromatin silencing, metabolism, and aging.Genes Dev2000https://conductscience.org/library/papers/10809662PubMed
57,628,449The membrane of peroxisomes in Saccharomyces cerevisiae is impermeable to NAD(H) and acetyl-CoA under in vivo conditions.EMBO J1995https://conductscience.org/library/papers/7628449PubMed
612,923,526Epigenetic silencing of RNA polymerase I transcription.Nat Rev Mol Cell Biol2003https://conductscience.org/library/papers/12923526PubMed
74,333,514The management of nicotinamide and nicotinic acid in the mouse.J Biol Chem1972https://conductscience.org/library/papers/4333514PubMed
83,139,649Quinolinic acid phosphoribosyltransferase: purification and partial characterization from human liver and brain.J Biochem1988https://conductscience.org/library/papers/3139649PubMed
911,816,029Identification and functional analysis of the Saccharomyces cerevisiae nicotinamidase gene, PNC1.Yeast2002https://conductscience.org/library/papers/11816029PubMed
1012,574,164Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis.J Biol Chem2003https://conductscience.org/library/papers/12574164PubMed

1 to 10 of 239

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Cited by514

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 743 citations.

PMIDTitleJournalYearIn PapersSource
42,938,323Association of the Schizophrenia Risk Locus rs10866912 with Cerebral Volumes, Diet, and Psychosis in the UK Biobank.Genes (Basel)2026https://conductscience.org/library/papers/42938323PubMed
42,880,261Lactate dehydrogenase A-dependent redox control of selective mRNA translation directs monocyte fate commitment.Immunity2026https://conductscience.org/library/papers/42880261PubMed
42,874,161Mycobacterium tuberculosis Rv2074 is a coenzyme F420-dependent mycobilin reductase.J Inorg Biochem2027https://conductscience.org/library/papers/42874161PubMed
42,846,758Restoring NAD+ pathways in brain aging and neurodegenerative diseases: roles of vitamin B3 metabolites, gut microbiota, and exercise in cognitive health.Front Nutr2026https://conductscience.org/library/papers/42846758PubMed
42,708,068Precision Nanodelivery Enables Spatiotemporal Control of NAD⁺ Metabolism in Ageing and Disease.Int J Nanomedicine2026https://conductscience.org/library/papers/42708068PubMed
42,646,333Nicotinamide Mononucleotide Adenylyltransferase 1 and NAD+ Homeostasis in Neuroprotection and Aging.Metabolites2026https://conductscience.org/library/papers/42646333PubMed
42,597,582Mitochondrial tRNASer(AGY) 12234A > G Mutation May Contribute to the Clinical Expression of Hypertrophic Cardiomyopathy-Associated tRNAIle 4263A > G Mutation.Hum Mutat2026https://conductscience.org/library/papers/42597582PubMed
42,514,375The Dynamic Coenzyme Network of B Vitamins in Nutritional Neuropathy and Neuropsychiatric Vulnerability: A Mechanistic Narrative Review.Nutrients2026https://conductscience.org/library/papers/42514375PubMed
42,514,364NAD Metabolism in Acute Myeloid Leukaemia: Biological Rationale and Therapeutic Opportunities.Nutrients2026https://conductscience.org/library/papers/42514364PubMed
42,499,152Extending Cofactor-Tethered Nanomachines to Complex Multienzyme Redox Cascades in Continuous Flow.ChemSusChem2026https://conductscience.org/library/papers/42499152PubMed

1 to 10 of 514

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Genes10

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
NADSYN155,191PubTator's text mininghttps://conductscience.org/library/genes/55191NCBI Gene
NAMPT10,135PubTator's text mininghttps://conductscience.org/library/genes/10135NCBI Gene
NAPRT93,100PubTator's text mininghttps://conductscience.org/library/genes/93100NCBI Gene
NMNAT164,802PubTator's text mininghttps://conductscience.org/library/genes/64802NCBI Gene
NMNAT223,057PubTator's text mininghttps://conductscience.org/library/genes/23057NCBI Gene
NMNAT3349,565PubTator's text mininghttps://conductscience.org/library/genes/349565NCBI Gene
NMRK154,981PubTator's text mininghttps://conductscience.org/library/genes/54981NCBI Gene
NMRK227,231PubTator's text mininghttps://conductscience.org/library/genes/27231NCBI Gene
NNT23,530PubTator's text mininghttps://conductscience.org/library/genes/23530NCBI Gene
QPRT23,475PubTator's text mininghttps://conductscience.org/library/genes/23475NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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